CDK12 gene inactivation: Study defines key driver of aggressive ovarian cancer

A salmonella outbreak tied to a major egg recall has sickened nearly 80 people and sent at least 21 to the hospital, health officials have said.

Exercising during chemotherapy and before surgery may help the body send more immune cells into cancerous tumors, according to a first-of-its-kind pilot study from the University of Surrey and Royal Surrey NHS Foundation Trust.

Using a modern imaging technology known as cryo-electron microscopy, researchers at UT Southwestern Medical Center have determined the structure of a protein called midnolin that's crucial to the survival of malignant cells in some leukemias, lymphomas, and multiple myelomas. Their findings, published in PNAS, provide insight into how this protein functions in cells and could inform the design of new pharmaceuticals that avoid the serious side effects of current therapies.

Researchers from the Biostatistics Unit at the Germans Trias i Pujol Research Institute (IGTP) have led a study, published in BMJ Open, which analyzes how in-hospital mortality evolved during four waves of the COVID-19 pandemic in Catalonia, taking into account the patients' ceiling of care.

Age-related macular degeneration (AMD) is a major cause of blindness, especially in older adults. A key feature of early AMD is the formation of drusen, clumps of debris made of lipids and proteins that collect between two layers at the back of the eye—the retinal pigment epithelium (RPE) and Bruch's membrane (BrM).

Hepatitis C virus (HCV) infection is highly associated with the development of metabolic dysfunction-associated steatotic liver disease (MASLD), with a diagnosis requiring the presence of steatotic liver disease (SLD) along with at least one of five cardiometabolic risk factors (CMRFs), including obesity, arterial hypertension (HTN), type 2 diabetes (T2D)/prediabetes, and dyslipidemia.

Just as folds are important in the ancient art of origami, they are also vital for the function of many proteins. Mutations in a protein associated with conditions such as seizures and autism spectrum disorder prevent it from folding correctly and hinder its movement to the cell surface, where it would normally do its job.

Northwestern University biophysicists have developed a new computational tool for identifying the gene combinations underlying complex illnesses like diabetes, cancer and asthma.

Depression and bipolar disorder of late onset may represent more than just mental health conditions. Growing evidence suggests these late-life mood disorders (LLMDs) could be not merely risk factors, but rather early warning signs of neurodegenerative diseases like dementia, even when they appear years before memory loss or other cognitive symptoms become apparent.

More young women in the United States are being diagnosed with breast cancer and several celebrities have helped raise awareness by sharing their stories.

As recommendations suggest extending hormone-based breast cancer treatment to 10 years for some patients, a new study sheds light on whether patients are opting for it.

The inaccuracy of race and ethnicity data found in electronic health records (EHRs) can negatively impact patient care as artificial intelligence (AI) is increasingly integrated into health care. Because hospitals and providers inconsistently collect such data and struggle to accurately classify individual patients, AI systems trained on these datasets can inherit and perpetuate racial bias.

Cancer cannot be understood as a single, uniform disease. The more we delve into studying each type of tumor, the more we recognize the need to subclassify the disease. This concept has led to what we now call precision oncology, characterizing the molecular features of a patient's specific cancer to determine the most effective treatment.

A new study from The University of Texas at Arlington details a novel strategy for how the body clears out dead cells during stress, revealing unexpected roles for well-known stress-response genes—a discovery that could help scientists better understand diseases affecting the immune system, brain and metabolism.

Scientists have discovered a link between bacteria in the mouth and gut and the progression of cognitive decline in Parkinson's disease. Specific changes in these bacteria, known as the microbiome, have been associated with cognitive decline in Parkinson's. This includes the shift from mild memory issues to dementia, a common and distressing symptom of the disease.

A compound found in the gut may reduce some of the manifestations of Alzheimer's disease, according to a Northwestern Medicine study published in the Journal of Clinical Investigation.

Creatine, the supplement popular with athletes for its ability to help build strength and power, is increasingly being recognized for its broad health benefits.

A new study from the University of Colorado Anschutz Medical Campus shows that primary care clinics can successfully help patients start using continuous glucose monitors (CGMs), which track blood sugar levels in real time.