Study delves into the complexity of the most aggressive form of prostate cancer

Age-related macular degeneration (AMD) is a major cause of blindness, especially in older adults. A key feature of early AMD is the formation of drusen, clumps of debris made of lipids and proteins that collect between two layers at the back of the eye—the retinal pigment epithelium (RPE) and Bruch's membrane (BrM).

Hepatitis C virus (HCV) infection is highly associated with the development of metabolic dysfunction-associated steatotic liver disease (MASLD), with a diagnosis requiring the presence of steatotic liver disease (SLD) along with at least one of five cardiometabolic risk factors (CMRFs), including obesity, arterial hypertension (HTN), type 2 diabetes (T2D)/prediabetes, and dyslipidemia.

Just as folds are important in the ancient art of origami, they are also vital for the function of many proteins. Mutations in a protein associated with conditions such as seizures and autism spectrum disorder prevent it from folding correctly and hinder its movement to the cell surface, where it would normally do its job.

Northwestern University biophysicists have developed a new computational tool for identifying the gene combinations underlying complex illnesses like diabetes, cancer and asthma.

Depression and bipolar disorder of late onset may represent more than just mental health conditions. Growing evidence suggests these late-life mood disorders (LLMDs) could be not merely risk factors, but rather early warning signs of neurodegenerative diseases like dementia, even when they appear years before memory loss or other cognitive symptoms become apparent.

A new study explains the genetic underpinnings of a rare and aggressive form of ovarian cancer—and offers a potential pathway for new treatments.

More young women in the United States are being diagnosed with breast cancer and several celebrities have helped raise awareness by sharing their stories.

As recommendations suggest extending hormone-based breast cancer treatment to 10 years for some patients, a new study sheds light on whether patients are opting for it.

The inaccuracy of race and ethnicity data found in electronic health records (EHRs) can negatively impact patient care as artificial intelligence (AI) is increasingly integrated into health care. Because hospitals and providers inconsistently collect such data and struggle to accurately classify individual patients, AI systems trained on these datasets can inherit and perpetuate racial bias.

A new study from The University of Texas at Arlington details a novel strategy for how the body clears out dead cells during stress, revealing unexpected roles for well-known stress-response genes—a discovery that could help scientists better understand diseases affecting the immune system, brain and metabolism.

Scientists have discovered a link between bacteria in the mouth and gut and the progression of cognitive decline in Parkinson's disease. Specific changes in these bacteria, known as the microbiome, have been associated with cognitive decline in Parkinson's. This includes the shift from mild memory issues to dementia, a common and distressing symptom of the disease.

A compound found in the gut may reduce some of the manifestations of Alzheimer's disease, according to a Northwestern Medicine study published in the Journal of Clinical Investigation.

Creatine, the supplement popular with athletes for its ability to help build strength and power, is increasingly being recognized for its broad health benefits.

A new study from the University of Colorado Anschutz Medical Campus shows that primary care clinics can successfully help patients start using continuous glucose monitors (CGMs), which track blood sugar levels in real time.

A new study to be presented at the SLEEP 2025 annual meeting found that teens with earlier, more efficient, and less variable sleep patterns at age 15 had better cardiovascular health at age 22.

Guns are now the leading cause of death for youth in the United States. Researchers from Mass General Brigham investigated whether firearm mortality rates among U.S. children ages 0–17 changed in the 13 years following a 2010 Supreme Court ruling that applied the Second Amendment to state and local governments.

Stress worsens sleep quality and can impair memory. Shinjae Chung, from the University of Pennsylvania, led a study to explore a neural pathway in male mice that stress may influence, to cause sleep and memory disturbances.

A unique study purposely giving participants Streptococcus pyogenes (Strep A) to learn how much penicillin it takes to prevent infection has found the amount needed is much lower than previously thought—a discovery that will transform thinking on treatment for people living with rheumatic heart disease (RHD).