Chronic alcohol use halts liver cell regeneration, new study finds

An international multidisciplinary team has demonstrated for the first time that CRISPR-based gene activation (CRISPRa) can be used to treat genetic heart disease in vivo. The study, published in the European Heart Journal and presented at the European Society of Cardiology Congress in Madrid, paves the way for novel targeted therapies for patients with genetic cardiac disorders. This approach could be especially useful for patients with conditions caused by mutations in genes too large to be targeted with conventional gene therapy.

An international team led by the Clínic-IDIBAPS-UB along with the Institute of Cancer Research, London, has developed a new method based on DNA methylation to decipher the origin and evolution of cancer, which makes it possible to predict its future clinical course. The study, published today in the journal Nature, analyzes the evolution of the tumors of 2,000 patients with leukemias and lymphomas.

Interorganizational collaborations are increasingly used to tackle some of society's most complex challenges. In health care, this takes many forms, such as strategic alliances, interorganizational networks, joint ventures, and public-private partnerships. The effectiveness of these collaborations hinges on participants pooling expertise toward the joint goal, but also on whether participants leverage each other's expertise for their own organizations' independent goals. The spillover of progress on those independent goals can sustain participation in the collaboration itself.

UK researchers on Wednesday announced the trial of a blood test for Alzheimer's which it is hoped will transform diagnosis of the disease.

Lyme disease can cause serious harm, but so can bogus tests and treatments.

Vision happens when patterns of light entering the eye are converted into reliable patterns of brain activity. This reliability allows the brain to recognize the same object each time it is seen. Our brains, however, are not born with this ability; instead, we develop it through visual experience. Collaborating scientists at MPFI and the Frankfurt Institute for Advanced Studies have recently discovered key circuit changes that lead to the maturation of reliable brain activity patterns.

The number of Michigan children whose parents died from overdose, suicide, homicide or other substance-related causes has surged since 2000, accounting for 2 in 5 parental deaths, a new University of Michigan study found.

An international research team has shown that lung cancer cells can form functional synapses with neurons, effectively hijacking the body's neural circuits to grow faster. The finding reveals a startling new dimension of cancer biology and opens promising new avenues for therapies against this disease. The study titled "Functional synapses between neurons and small-cell lung cancer" is published in Nature.

Micro- and nanoplastics prevalent in the environment routinely enter the human body through the water we drink, foods we eat, and even the air we breathe. Those plastic particles infiltrate all systems of the body, including the brain, where they can accumulate and trigger Alzheimer's-like conditions, according to a new study by researchers in the University of Rhode Island College of Pharmacy.

In a three‐year study involving more than 5,000 residents of Israel before and after the mass traumatic events of October 7, 2023, those who watched extensive media coverage of the attacks were found to be more likely to develop post‐traumatic stress disorder (PTSD).

An unusual therapy developed at The Jackson Laboratory (JAX) could change the way the world fights influenza, one of the deadliest infectious diseases. In a new study in Science Advances, researchers report that a cocktail of antibodies protected mice—including those with weakened immune systems—from nearly every strain of influenza tested, including avian and swine variants that pose pandemic threats.

Northeastern and Midwestern residents tend to have higher physical, social, and financial—i.e., "traditional"—wellness, while Southern residents have higher "existential" wellness, involving a sense of purpose and community identity, per an analysis of survey data from more than 325,000 U.S. residents.

Maintaining an open airway is a critical priority in emergency medicine. Without the flow of oxygen, other emergency interventions can become ineffective at saving the patient's life. However, creating this airway through endotracheal intubation is a difficult task for highly trained individuals and under the best of circumstances.

A new University of South Florida study published in Menopause highlights a largely overlooked health issue: voice changes that many women experience during menopause, often triggered by falling levels of estrogen and progesterone.

University of Hawaiʻi at Mānoa scientists have uncovered a direct link between a missing Y chromosome gene and male infertility. Their new research reveals that deleting this single gene in mice not only caused infertility but also disrupted hundreds of other genes vital for healthy sperm. The findings, published in Cell Death & Differentiation, offer significant implications for understanding reproductive health.

The chance to win a few dollars every time they pass a drug test, and the possibility of bigger prizes the longer they stay off drugs like methamphetamine and cocaine, may be enough to keep veterans from dying as they navigate early recovery, a new study suggests.

A major UK study has provided the most comprehensive analysis to date of a cancer diagnosis pathway for patients presenting with non-specific symptoms (NSS), such as unexplained weight loss or fatigue. These symptoms can indicate a wide range of conditions, from benign diseases to late-stage cancers, making timely and accurate diagnosis a significant challenge in primary care.

In 2017, a flight from Miami to Berlin took a surprising turn when passengers discovered a rat on board. After landing, it was captured and handed over to the Friedrich-Loeffler-Institut (FLI). There, it was not only seen as a nuisance, but also as an opportunity to examine it as a possible carrier of pathogens.