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Computational clock identifies compounds that may rejuvenate aging brain cells

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  • 2025-07-22 22:10 event
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Computational clock identifies compounds that may rejuvenate aging brain cells
What if there was a way to make aging brain cells younger again? An international research team from Spain and Luxembourg recently set out to address this question. After developing an aging clock capable of assessing the biological age of the brain, they used it to identify possible brain-rejuvenating interventions. The computational tool they created, recently presented in the journal Advanced Science, constitutes a valuable resource to find compounds with therapeutic potential for neurodegenerative diseases.

1.458. 43% of drug-caused deaths by health care workers used hospital-only drugs

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Nearly half of drug-caused deaths by health care workers involved drugs that were obtained from their place of work, new research finds.

1.459. Skin buckles as you age, and that's why wrinkles form, study shows

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Aging skin stretches, contracts and buckles under pressure—and that's how wrinkles form, according to new experimental evidence from scientists at Binghamton University, State University of New York.

1.460. CDK4/6 inhibitor combination could overcome drug resistance in advanced prostate cancer

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With an estimated 1.5 million new cases and 397,000 deaths worldwide, prostate cancer is the world's second most frequent cancer and the fifth leading cause of cancer death among men in 2022. Hormone therapy based on the inhibition of androgen receptor signaling (ARPi) is the mainstay of treatment for metastatic prostate cancer (mPC). However, cancer drug resistance ultimately arises, highlighting the need for more effective therapeutic strategies.

1.461. More than telehealth: Social factors shape heart health

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A team of researchers led by two University of Mississippi professors is working to unlock patterns and causes of the No. 1 killer of Mississippians: heart disease.

1.462. New research highlights neurodivergent friendship patterns

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New research from Abertay University has shed fresh light on how neurodivergent (ND) people form and experience friendships, highlighting a strong preference for building connections with others who share their neurotype.

1.463. Pumped up with poison: New research shows many anabolic steroids contain toxic metals

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Eighteen-year-old Mark scrolls Instagram late at night, watching videos of fitness influencers showing off muscle gains and lifting the equivalent of a baby elephant off the gym floor.

1.464. From painkillers to antibiotics: Five medicines that could harm your hearing

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When we think about the side effects of medicines, we might think of nausea, fatigue or dizziness. But there's another, lesser-known risk that can have lasting—and sometimes permanent—consequences: hearing loss. A wide range of prescription and over-the-counter drugs are known to be ototoxic, meaning they can damage the inner ear and affect hearing or balance.

1.465. Are you aging well? Take the five-part quiz that could help change your future

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Most of us want to enjoy later life feeling strong, connected, and mentally sharp. But how often do we stop to think about whether the things we're doing right now are helping us get there?

1.466. Three reasons buffets can be a recipe for a health disaster—and how to keep diners safe

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You pile your plate high at the buffet, savoring the freedom to try a little bit of everything. But while your tastebuds might be celebrating, your gut could be at risk.

1.467. Computational clock identifies compounds that may rejuvenate aging brain cells

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What if there was a way to make aging brain cells younger again? An international research team from Spain and Luxembourg recently set out to address this question. After developing an aging clock capable of assessing the biological age of the brain, they used it to identify possible brain-rejuvenating interventions. The computational tool they created, recently presented in the journal Advanced Science, constitutes a valuable resource to find compounds with therapeutic potential for neurodegenerative diseases.

1.468. Here's why three-person embryos are a breakthrough for science—but not LGBTQ+ families

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Last week, scientists announced the birth of eight healthy babies in the United Kingdom conceived with DNA from three people. Some headlines have called it "three-person IVF."

1.469. Gene signature predicts aggressive pancreatic cancer before symptoms appear

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Precancerous cells must adapt to and overcome cellular stress and inflammation in order to progress and form malignant tumors. Now, researchers at University of California San Diego School of Medicine have identified a link between stress and inflammation and pancreatic ductal adenocarcinoma (PDAC), one of the most aggressive and lethal types of cancer.

1.470. COVID, flu, RSV: How these common viruses are tracking this winter—and how to protect yourself

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Winter is here, and with it come higher rates of respiratory illnesses. If you've been struck down recently with a sore throat, runny nose and a cough, or perhaps even a fever, you're not alone.

1.471. COVID-19 pandemic may have aged our brains, new study suggests

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A new study, led by experts at the University of Nottingham, has found that the COVID-19 pandemic may have accelerated people's brain health, even if they were never infected with the virus.

1.472. Study uncovers how the immune system fends off gut parasites

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New research from the University of Pittsburgh reveals how the immune system defends against intestinal parasitic worms, or helminths, one of the most common infections worldwide in communities with limited access to clean water and sanitation.

1.473. Toxic fungus from King Tutankhamun's tomb yields cancer-fighting compounds—new study

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In November 1922, archaeologist Howard Carter peered through a small hole into the sealed tomb of King Tutankhamun. When asked if he could see anything, he replied: "Yes, wonderful things." Within months, however, Carter's financial backer Lord Carnarvon was dead from a mysterious illness. Over the following years, several other members of the excavation team would meet similar fates, fueling legends of the "pharaoh's curse" that have captivated the public imagination for just over a century.

1.474. Understanding thyroid cancer risk, symptoms and treatment

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Your thyroid gland may be small, but it plays a big role in keeping your body running. Located at the base of your neck where a bow tie would sit, this butterfly-shaped gland produces hormones that regulate your metabolism, acting like the throttle on an engine for your entire body.

1.475. Online physio program brings fall prevention into the home

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The national TOP UP clinical trial, a partnership between University of Sydney researchers and aged care providers, found participants could walk and get out of a chair more easily, were less likely to fall, and experienced less pain.

1.476. New study finds health care costs go up with increased acquisition of private physician practices

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New research published today as a working paper by the National Bureau of Economic Research finds that the widespread, rapid acquisition of private physician practices by hospitals is pushing up health care prices across the United States.

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