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CDK4/6 inhibitor combination could overcome drug resistance in advanced prostate cancer

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  • 2025-07-22 23:20 event
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CDK4/6 inhibitor combination could overcome drug resistance in advanced prostate cancer
With an estimated 1.5 million new cases and 397,000 deaths worldwide, prostate cancer is the world's second most frequent cancer and the fifth leading cause of cancer death among men in 2022. Hormone therapy based on the inhibition of androgen receptor signaling (ARPi) is the mainstay of treatment for metastatic prostate cancer (mPC). However, cancer drug resistance ultimately arises, highlighting the need for more effective therapeutic strategies.

1.422. Childhood gastrointestinal disorders may be predictive for interstitial cystitis

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Childhood gastrointestinal (GI) disorders may be predictive for interstitial cystitis (IC), according to a study published online June 25 in Neurourology & Urodynamics.

1.423. Psychedelics and cannabis offer treatment hope for people with eating disorders

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A pioneering international survey of people living with eating disorders has found that cannabis and psychedelics, such as "magic mushrooms" or LSD, were best rated as alleviating symptoms by respondents who self-medicated with the non-prescribed drugs.

1.424. How falling vaccination rates are fueling the antibiotic resistance crisis

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Antibiotic resistance is one of the biggest health threats we face today. It's often blamed on the overuse of antibiotics, and for a good reason. But there's another major factor quietly driving this crisis that doesn't get as much attention: low vaccination rates.

1.425. Inflammatory bowel disease possibly accelerates dementia

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New research from Karolinska Institutet demonstrates a link between inflammatory bowel disease and faster cognitive decline among dementia patients. The study, which is published in the journal Gut, indicates a need for personalized treatments, researchers say.

1.426. Chemical variations in prostate cancer calcifications analyzed to identify new diagnostic markers

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Researchers at Keele University have published the first investigation into the variation in the chemical makeup of calcifications caused by prostate cancer, in the hope of identifying new markers to improve early diagnosis.

1.427. The A to K of vitamins: What you need and where to get it

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The late, great comedian Barry Humphries (of Dame Edna fame) once spoke whimsically about the health benefits of kale. Just one fistful, he joked, contained enough essential vitamins, minerals and trace elements to keep you in a sedentary position in the bathroom for two whole days. Apparently, it wasn't tasty enough to justify a second helping.

1.428. Access to green spaces may be linked to lower risk of neurodevelopmental disorders in children

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Living near green spaces before and during pregnancy as well as in early childhood is associated with a reduced risk of neurodevelopmental disorders, according to Rutgers Health researchers.

1.429. 43% of drug-caused deaths by health care workers used hospital-only drugs

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Nearly half of drug-caused deaths by health care workers involved drugs that were obtained from their place of work, new research finds.

1.430. Skin buckles as you age, and that's why wrinkles form, study shows

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Aging skin stretches, contracts and buckles under pressure—and that's how wrinkles form, according to new experimental evidence from scientists at Binghamton University, State University of New York.

1.431. CDK4/6 inhibitor combination could overcome drug resistance in advanced prostate cancer

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With an estimated 1.5 million new cases and 397,000 deaths worldwide, prostate cancer is the world's second most frequent cancer and the fifth leading cause of cancer death among men in 2022. Hormone therapy based on the inhibition of androgen receptor signaling (ARPi) is the mainstay of treatment for metastatic prostate cancer (mPC). However, cancer drug resistance ultimately arises, highlighting the need for more effective therapeutic strategies.

1.432. More than telehealth: Social factors shape heart health

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A team of researchers led by two University of Mississippi professors is working to unlock patterns and causes of the No. 1 killer of Mississippians: heart disease.

1.433. New research highlights neurodivergent friendship patterns

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New research from Abertay University has shed fresh light on how neurodivergent (ND) people form and experience friendships, highlighting a strong preference for building connections with others who share their neurotype.

1.434. Pumped up with poison: New research shows many anabolic steroids contain toxic metals

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Eighteen-year-old Mark scrolls Instagram late at night, watching videos of fitness influencers showing off muscle gains and lifting the equivalent of a baby elephant off the gym floor.

1.435. From painkillers to antibiotics: Five medicines that could harm your hearing

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When we think about the side effects of medicines, we might think of nausea, fatigue or dizziness. But there's another, lesser-known risk that can have lasting—and sometimes permanent—consequences: hearing loss. A wide range of prescription and over-the-counter drugs are known to be ototoxic, meaning they can damage the inner ear and affect hearing or balance.

1.436. Are you aging well? Take the five-part quiz that could help change your future

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Most of us want to enjoy later life feeling strong, connected, and mentally sharp. But how often do we stop to think about whether the things we're doing right now are helping us get there?

1.437. Three reasons buffets can be a recipe for a health disaster—and how to keep diners safe

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You pile your plate high at the buffet, savoring the freedom to try a little bit of everything. But while your tastebuds might be celebrating, your gut could be at risk.

1.438. Computational clock identifies compounds that may rejuvenate aging brain cells

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What if there was a way to make aging brain cells younger again? An international research team from Spain and Luxembourg recently set out to address this question. After developing an aging clock capable of assessing the biological age of the brain, they used it to identify possible brain-rejuvenating interventions. The computational tool they created, recently presented in the journal Advanced Science, constitutes a valuable resource to find compounds with therapeutic potential for neurodegenerative diseases.

1.439. Here's why three-person embryos are a breakthrough for science—but not LGBTQ+ families

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Last week, scientists announced the birth of eight healthy babies in the United Kingdom conceived with DNA from three people. Some headlines have called it "three-person IVF."

1.440. Gene signature predicts aggressive pancreatic cancer before symptoms appear

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Precancerous cells must adapt to and overcome cellular stress and inflammation in order to progress and form malignant tumors. Now, researchers at University of California San Diego School of Medicine have identified a link between stress and inflammation and pancreatic ductal adenocarcinoma (PDAC), one of the most aggressive and lethal types of cancer.

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