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FDA approves sublingual, nonopioid daily treatment for fibromyalgia

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  • 2025-08-21 01:20 event
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FDA approves sublingual, nonopioid daily treatment for fibromyalgia
The U.S. Food and Drug Administration has approved Tonmya (cyclobenzaprine hydrochloride) sublingual tablets for the treatment of fibromyalgia in adults.

128. AI model redefines multiple sclerosis as a continuum with dynamic stages instead of subtypes

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Multiple sclerosis (MS) has long been regarded as a disease with different subtypes such as "relapsing" or "progressive." An international study, published on August 20, 2025, in Nature Medicine under the leadership of the Medical Center—University of Freiburg and the University of Oxford, challenges this dogmatic model after analyzing the NO.MS cohort (study data from Novartis).

129. What happens in the brain when it learns something new

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Memories of significant learning experiences—like the first time a driver gets a speeding ticket—are sharp, compared to the recollection of everyday events—like what someone ate for dinner two weeks ago. That's because the human brain is primed to learn from helpful associations.

130. Free, confidential access to contraception boosts use among Ontario youth: Study

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Young people who are offered confidential and free access to prescription contraception methods are significantly more likely to use them, according to a new McMaster University study.

131. Child eyewitnesses can be unreliable, but new techniques can support them

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There is often a dramatic scene in crime shows where an eyewitness points to a suspect in a police lineup. This identification looks convincing on television, and it is also convincing in real-world investigations. But here's the problem: eyewitnesses can often be wrong. Their mistakes are a leading cause of wrongful convictions.

132. Most air cleaning devices have not been tested on people and little is known about their potential harms

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Portable air cleaners aimed at curbing indoor spread of infections are rarely tested for how well they protect people—and very few studies evaluate their potentially harmful effects. That's the upshot of a detailed review of nearly 700 studies that we co-authored in the journal Annals of Internal Medicine.

133. Imaging approach illuminates how weight loss drugs target the brain and pancreas

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An international research team from Leibniz-FMP, the University of Oxford, and the University of Birmingham have developed a novel imaging approach to track how popular dual agonist drugs like tirzepatide interact with cells in the pancreas and brain. Published this week in Nature Metabolism, the findings could support the design of more effective treatments for diabetes and obesity.

134. Novel strategy for small cell lung cancer treatment prompts clinical trial

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New research from Dana-Farber Cancer Institute shows that a new class of drug results in cell death in cancers, such as small cell lung cancer, with a disabled quality control cell cycle checkpoint known as the G1/S checkpoint. The evidence gathered in the Oser Lab at Dana-Farber supports testing of the strategy in humans.

135. Cancer-associated nerve injury can lead to chronic inflammation and immunotherapy resistance

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Cancer cells can break down the protective covers around nerves, causing nerve injury that triggers chronic inflammation, leading to immune exhaustion and eventual resistance to immunotherapy, according to new research from the University of Texas MD Anderson Cancer Center.

136. Richmond's youth violence risk overlaps with historic redlining, new research finds

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The legacy of redlining—the 20th-century mapping practice that denied loans and other services to minorities based on their neighborhoods—continues to resonate in cities. New research from Virginia Commonwealth University and Virginia State University finds a spatial overlap between formerly redlined neighborhoods and violent injuries among youth in the city of Richmond today.

137. FDA approves sublingual, nonopioid daily treatment for fibromyalgia

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The U.S. Food and Drug Administration has approved Tonmya (cyclobenzaprine hydrochloride) sublingual tablets for the treatment of fibromyalgia in adults.

138. Breaking a sweat: Using chloride in sweat to help diagnose cystic fibrosis

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Sweat does more than just cool down an overheating body. Measuring the chemical makeup of an individual's sweat—specifically the levels of chloride, a chemical component of salt—can serve as an early warning system to help inform the diagnosis of cystic fibrosis, a genetic disease that damages the lungs and digestive system.

139. Epigenomic landscapes of fat tissue cells reveal how they shape obesity risk

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A new study has created the first single-cell map of how DNA is regulated and organized inside different cell-types of human fat tissue. The research shows that many genetic risk factors for abdominal obesity reside in epigenomic regions of fat cells, offering clues about how body fat is genetically and epigenetically regulated and how it might be better controlled. The study, by co-first authors Zeyuan (Johnson) Chen and Sankha Subhra Das, is published in Nature Genetics.

140. FDA approves Wegovy to treat serious liver disease

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The U.S. Food and Drug Administration (FDA) has approved Novo Nordisk's popular weight-loss drug Wegovy to treat a serious form of fatty liver disease.

141. DNA 'detangler' gene found to prevent deadly blood cell inflammation and cancer

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A new Northwestern Medicine study has revealed how a common inherited mutation disrupts red blood cell development and sparks inflammation that can lead to leukemia, according to findings published in Nature Communications.

142. AI platform uses 3D visualization to reveal disease biomarkers in multiomics data

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Researchers say the ability to visualize health data in three dimensions can unlock patterns and relationships among predictive biomarkers that conventional data visualization can't convey. That's why Zeeshan Ahmed and his team at Rutgers developed 3D IntelliGenes, an advanced artificial intelligence and machine-learning platform with the ability to visually analyze multiple types of biological and clinical data—known as multiomics.

143. Dr. Robot will see you now? Medical robots expected to support doctors, not take over patient care

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The robot doctor will see you now? Not for the foreseeable future, anyway.

144. Natural molecule discovery could help glaucoma patients

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Findings could lead to earlier detection and treatment for those suffering from the serious eye condition.

145. Researchers reverse autism symptoms in mice with epilepsy drugs

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Stanford Medicine scientists investigating the neurological underpinnings of autism spectrum disorder have found that hyperactivity in a specific brain region could drive behaviors commonly associated with the disorder.

146. Access to green space a mental health lifeline during COVID-19 pandemic, research reveals

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A new national study led by researchers from Carleton University and the University of Toronto reveals that older adults living in greener neighborhoods were less likely to experience depression during the early months of the COVID-19 pandemic.

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