AI platform uses 3D visualization to reveal disease biomarkers in multiomics data

An international research team from Leibniz-FMP, the University of Oxford, and the University of Birmingham have developed a novel imaging approach to track how popular dual agonist drugs like tirzepatide interact with cells in the pancreas and brain. Published this week in Nature Metabolism, the findings could support the design of more effective treatments for diabetes and obesity.

New research from Dana-Farber Cancer Institute shows that a new class of drug results in cell death in cancers, such as small cell lung cancer, with a disabled quality control cell cycle checkpoint known as the G1/S checkpoint. The evidence gathered in the Oser Lab at Dana-Farber supports testing of the strategy in humans.

Cancer cells can break down the protective covers around nerves, causing nerve injury that triggers chronic inflammation, leading to immune exhaustion and eventual resistance to immunotherapy, according to new research from the University of Texas MD Anderson Cancer Center.

The legacy of redlining—the 20th-century mapping practice that denied loans and other services to minorities based on their neighborhoods—continues to resonate in cities. New research from Virginia Commonwealth University and Virginia State University finds a spatial overlap between formerly redlined neighborhoods and violent injuries among youth in the city of Richmond today.

The U.S. Food and Drug Administration has approved Tonmya (cyclobenzaprine hydrochloride) sublingual tablets for the treatment of fibromyalgia in adults.

Sweat does more than just cool down an overheating body. Measuring the chemical makeup of an individual's sweat—specifically the levels of chloride, a chemical component of salt—can serve as an early warning system to help inform the diagnosis of cystic fibrosis, a genetic disease that damages the lungs and digestive system.

A new study has created the first single-cell map of how DNA is regulated and organized inside different cell-types of human fat tissue. The research shows that many genetic risk factors for abdominal obesity reside in epigenomic regions of fat cells, offering clues about how body fat is genetically and epigenetically regulated and how it might be better controlled. The study, by co-first authors Zeyuan (Johnson) Chen and Sankha Subhra Das, is published in Nature Genetics.

The U.S. Food and Drug Administration (FDA) has approved Novo Nordisk's popular weight-loss drug Wegovy to treat a serious form of fatty liver disease.

A new Northwestern Medicine study has revealed how a common inherited mutation disrupts red blood cell development and sparks inflammation that can lead to leukemia, according to findings published in Nature Communications.

The robot doctor will see you now? Not for the foreseeable future, anyway.

Findings could lead to earlier detection and treatment for those suffering from the serious eye condition.

Stanford Medicine scientists investigating the neurological underpinnings of autism spectrum disorder have found that hyperactivity in a specific brain region could drive behaviors commonly associated with the disorder.

A new national study led by researchers from Carleton University and the University of Toronto reveals that older adults living in greener neighborhoods were less likely to experience depression during the early months of the COVID-19 pandemic.

Fewer than half of all adolescents with major depressive episode (MDE) received mental health care in the US in 2022, with the odds of specialist treatment being even lower among marginalized groups, according to a study published in the open-access journal PLOS Mental Health by Su Chen Tan and colleagues at University of Tennessee.

Patients with some cancers, autoimmune diseases, and metabolic disorders often endure time-consuming intravenous (IV) infusions to receive the best protein-based treatments available. Because these protein therapeutics require high doses to be effective and are typically formulated at low concentrations to remain stable, IV infusion has been, until now, the only option.

Older adults often don't realize how vulnerable they are to extreme heat and most aren't prepared for long periods of hot weather, according to a review of more than 40 studies.

Researchers have developed an AI tool that can help doctors predict who might develop a potentially fatal heart condition, just from an ECG.

An innovative method that uses modified versions of a bacterial virus effective at delivering treatments to human cells shows promise as a more inexpensive and efficient way to treat some deadly genetic diseases.