Gene–diet interactions help regulate the body's daily rhythms, research reveals

Sustained hypoxia affects orthodontic tooth movement (OTM) by altering osteoclast and osteoblast differentiation, report researchers from the Institute of Science Tokyo, Japan. Hypoxic conditions resulted in reduced alveolar bone levels after OTM and lower expression of runt-related transcription factor 2 and vascular endothelial growth factor. These findings, observed in a rat model, provide critical insights into the bone remodeling process in OTM under hypoxia.

Three widely used artificial intelligence chatbots generally do a good job responding to very-high-risk and very-low-risk questions about suicide, but they are inconsistent in answering questions about suicide that may pose intermediate risks, according to a new study appearing in Psychiatric Services.

An analysis using data from the National Health and Nutrition Examination Survey (NHANES) among 5,374 women of reproductive age indicates that two thirds of women within this demographic have at least one modifiable risk factor, such as low folate status or unmanaged diabetes, that can increase the chance of serious birth defects.

A Mediterranean-style diet, in combination with reduced caloric intake, moderate physical activity, and professional support for weight loss, may cut the risk of type 2 diabetes (T2D) by 31%, according to a new study co-authored by researchers at Harvard T.H. Chan School of Public Health.

A systematic review analyzed the associations of high-concentration delta-9-tetrahydrocannabinol (THC) cannabis products with mental health outcomes. The review found that high-concentration THC products are associated with unfavorable mental health outcomes, particularly for psychosis or schizophrenia and cannabis use disorder (CUD).

Researchers from the University of Maryland School of Medicine have developed a new and highly effective application of an artificial intelligence (AI) tool to quickly scan notes in electronic medical records and identify high-risk patients who may have been infected with H5N1 avian influenza or "bird flu," according to new findings published in the journal Clinical Infectious Diseases.

Researchers at VCU Massey Comprehensive Cancer Center have developed a new computational tool called Vesalius, which could help clinicians understand the complex relationships between cancer cells and their surrounding cells, leading to potential discoveries regarding the development of hard-to-treat cancers.

Inflammatory bowel disease, in which the immune system attacks the gut, is a painful chronic condition that affects three million Americans. Rates of IBD are rising, and there's currently no cure. IBD can also be deadly: Up to 8% of people with the disease develop blood clots, which can lead to heart attack and stroke.

Over seven million Americans are living with Alzheimer's disease (AD), and the heartbreaking day-to-day battle with the effects of cognitive decline. According to the Alzheimer's Association, the brain changes that cause the disease actually begin 20 years or more before symptoms start, highlighting the critical need for early and accurate diagnosis. However, current diagnostic tools involve painful spinal taps, expensive scans and cognitive tests that can be limited in their accuracy.

One of the most captivating mysteries about the immune system is how it manages to keep its healthy equilibrium—staying on high alert and ready to react to harmful invaders or damaged cells, while remaining calm in the presence of innocent triggers such as food.

Discharging a patient to a skilled nursing facility or other type of post-acute care facility after surgery can add more than $5,000 to care costs and is associated with worse outcomes for older adult patients.

Most research suggests that opioid overdoses involving multiple substances in the United States typically occur among people aged 25–54. However, a new study led by Boston University School of Public Health (BUSPH) and Mass General Brigham for Children indicates that polysubstance-involved opioid overdoses are also prevalent among youth.

A new study at the University of North Carolina at Chapel Hill has discovered a surprising new mechanism in the brain that may explain why people recovering from drug addiction often relapse.

Scientists at the Icahn School of Medicine at Mount Sinai have developed a powerful new computational tool that could transform how cancer tissues are analyzed and help pave the way for more personalized treatments. The study, published in Nature Biomedical Engineering, introduces MARQO, a next-generation image analysis process that extracts detailed cellular and spatial information from tumor tissue slides with unprecedented accuracy and scalability.

Research into Blue Zones—regions of the world where people tend to live longer—shows that having a sense of purpose in life may help people live longer.

An estimated 50 million people worldwide have dementia, with Alzheimer's disease—accounting for more than 70%—being the representative neurodegenerative brain disorder. A Korean research team has, for the first time, identified at the molecular level that tau and amyloid-β, the two key pathological proteins of Alzheimer's disease, directly communicate to regulate toxicity.

Hundreds of children in Indonesia lined up for free measles shots Monday as authorities rolled out a vaccination campaign in response to an outbreak that has caused 17 deaths.

A person who traveled to El Salvador has been diagnosed with New World screwworm—the first reported U.S. case tied to travel to a country with a current outbreak.