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Gene therapy may be key to permanently putting HIV into dormant state

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  • 2025-06-26 02:35 event
  • 2 months ago schedule
Gene therapy may be key to permanently putting HIV into dormant state
In a study of human immune cells infected with HIV, the virus that causes AIDS, scientists at Johns Hopkins Medicine say a molecule within HIV itself can be manipulated and amplified to force the virus into long-term dormancy, a state in which HIV does not replicate.

2.983. Tackling depressive symptoms in high school students by honing emotional and social skills

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Today, high school students worldwide face unprecedented levels of stress as they navigate academic pressures, issues with social identity, and future career decisions.

2.984. Key proteins linked to brain tumor growth offer hope for personalized therapies

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Researchers from the University of Plymouth have identified proteins that fuel the growth of the most common type of brain tumor, a discovery that could ultimately lead to less invasive treatments for patients.

2.985. Why there's a growing backlash against plant-based diets

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People in the UK are eating too much meat—especially processed meat—according to a recent report from the Food Foundation, a UK charity.

2.986. Role of tumor microenvironment in nasopharyngeal carcinoma progression uncovered

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A study led by clinician-scientists and researchers at the National Cancer Centre Singapore (NCCS) has found that the tumor immune microenvironment (TIME) plays a critical role in the progression of nasopharyngeal carcinoma (NPC) commonly known as nose cancer. These insights are paving the way for precision oncology approaches, some of which are currently used in clinical trials at NCCS. The findings are published in Cell Reports Medicine.

2.987. Liver organoid generates organ-specific blood vessels for the first time

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Scientists from Cincinnati Children's and colleagues based in Japan report achieving a major step forward in organoid technology: producing liver tissue that grows its own internal blood vessels.

2.988. Researchers develop high-performance, open-source AI for breast cancer detection

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In a major breakthrough, a team of researchers from The City College of New York and Memorial Sloan Kettering Cancer Center (MSKCC) has developed a new AI model that can detect breast cancer in MRI images and pinpoint the location of tumors.

2.989. AI-assisted model enhances low-quality MRI heart scans

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An AI-assisted model developed by researchers from the University of Missouri School of Medicine and the School of Engineering can take low-quality MRI heart scans and turn them into high-quality images, while reducing the time needed to scan the heart by about 90%.

2.990. Common medicine for autoimmune diseases works on giant cell arteritis

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A common medication already used for autoimmune diseases such as rheumatoid arthritis is effective for patients with giant cell arteritis, according to findings from a team at the Perelman School of Medicine at the University of Pennsylvania published in the New England Journal of Medicine.

2.991. Living in more disadvantaged neighborhoods may increase risk of inflammation and dementia biomarkers

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People living in more disadvantaged neighborhoods may be more likely to have biomarkers for inflammation and Alzheimer's disease, according to a study published in Neurology. The study does not prove that neighborhood factors cause these biomarkers: it only shows an association.

2.992. Gene therapy may be key to permanently putting HIV into dormant state

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In a study of human immune cells infected with HIV, the virus that causes AIDS, scientists at Johns Hopkins Medicine say a molecule within HIV itself can be manipulated and amplified to force the virus into long-term dormancy, a state in which HIV does not replicate.

2.993. Study finds vitamin C boosts skin thickness by reactivating growth genes

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The skin acts as the body's first line of defense against external threats. However, as we age, the epidermis—the outermost layer of skin—gradually becomes thinner and loses its protective strength. About 90% of the cells in this layer are keratinocytes, which originate from deeper layers of the epidermis and migrate upward, ultimately forming the skin's protective barrier.

2.994. How aortic valve stenosis develops

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There is currently no way to stop calcification of the aortic valve. If all else fails, the valve must be replaced. To better understand the development of this common disease, researchers from Bochum and Bonn have taken a close look at defective valves.

2.995. International study validates efficacy of a drug in adults with neurofibromatosis type 1

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An international study has shown that a drug called selumetinib can reduce the pain and size of tumors caused in adults by neurofibromatosis type 1 (NF1), a rare genetic disease for which there is currently no effective pharmacological treatment.

2.996. Early biomarkers of brain damage progression in Alzheimer's disease revealed

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A new study led by scientists from BGI Genomics' Institute of Intelligent Medical Research (IIMR) has identified early biomarkers and disease neurons associated with Alzheimer's Disease (AD) pathology.

2.997. Dementia cells' misplaced genetic messages may be re-established by drug currently in clinical trials

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Researchers at the Francis Crick Institute and UCL have shown that genetic messages are misplaced in nerve cells in a model of Alzheimer's disease and frontotemporal dementia. These messages mostly affect the function of the mitochondria, the cell's energy producers, and can be re-established using a drug currently in clinical trials.

2.998. Q&A: Researcher discusses quest to halt neurodegenerative disorders such as Alzheimer's disease

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Misplaced car keys, forgotten names and other lapses in memory are a normal part of life, especially as you age. However, more serious memory problems can be a sign of cognitive impairment or dementia like Alzheimer's disease.

2.999. Gamma-linolenic acid found to help relax constricted coronary arteries

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A new study by Toho University has revealed that gamma-linolenic acid (GLA), a fatty acid commonly found in plant oils such as evening primrose and borage, can directly relax constricted coronary arteries by blocking a key receptor involved in blood vessel contraction. This discovery offers promising implications for the prevention of coronary spasms and angina.

3.000. Spatial mapping reveals network of cells and genes involved in Crohn's disease complication

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Up to half of patients with Crohn's disease, an inflammatory bowel disease, develop a complication called fibrosis, where the gut becomes scarred and obstructed, causing pain and bloating. Currently, the only treatment option for these gut "strictures" is surgery.

3.001. How AI is becoming a new social presence that could change human relationships and brain functions

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As artificial intelligence (AI) chatbots and virtual agents become part of everyday life—from customer service and health care to personal companionship—a critical question arises: How do these AI interactions affect social and emotional dynamics?

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