Gene therapy trial offers breakthrough for rare genetic disorder

Using mathematical analysis of patterns of human and animal cell behavior, scientists say they have developed a computer program that mimics the behavior of such cells in any part of the body. Led by investigators at Indiana University, Johns Hopkins Medicine, the University of Maryland School of Medicine and Oregon Health & Science University, the new work was designed to advance ways of testing and predicting biological processes, drug responses and other cell dynamics before undertaking more costly experiments with live cells.

Thanks to vaccinations against SARS-CoV-2 in the period 2020–2024, 2.533 million deaths were prevented at the global level; one death was avoided for every 5,400 doses of vaccine administered.

Researchers from Columbia Engineering have established a framework for the design of bioactive injectable hydrogels formulated with extracellular vesicles (EVs) for tissue engineering and regenerative medicine applications.

The ongoing conflict in the Middle East is having a significant impact on the mental health and well-being of Australian women who migrated from directly impacted countries, or have family ties to the region, according to researchers from UNSW Sydney and The Australian National University (ANU).

In soccer games, "ball-trapping"—quickly changing direction after receiving a pass to transition into an attack—is a critical maneuver. This action can significantly influence the flow of a match, especially when executed effectively in the space between an opponent's midfield and defensive lines. However, the specific physical techniques used by skilled ball-trappers during actual gameplay have not been well understood.

The number of Americans caring for an older or disabled family member has risen dramatically during the past 10 years, according to a new AARP policy report.

A virus that typically infects black-eyed peas is showing great promise as a low-cost, potent cancer immunotherapy—and researchers are uncovering why.

Researchers at the University of Arizona Mel and Enid Zuckerman College of Public Health found that certain kinds of long-lasting chemicals firefighters are exposed to may affect the activity of genes linked to cancer and other diseases. The findings appear in the journal Environmental Research.

This week, the World Health Organization (WHO) raised concerns about a surge in the number of cases of a mosquito-borne viral infection called chikungunya.

Age often brings a gradual decline in the ability to learn new things and retain memories. This phenomenon, often associated with the elderly, is linked to the brain's deteriorating capacity to generate new neurons—a process that primarily occurs in the hippocampus—as neural stem cells (NSCs) divide and mature.

Oregon Health & Science University-led research is reporting that daily full-body emollient use starting before 9 weeks of age lowered atopic dermatitis incidence by 24 months in a representative US infant cohort.

GLP1 agonist drugs, commonly known by brand names such as Ozempic and Mounjaro, reduce asthma symptoms in obese people according to a new study from the University of Aberdeen and the Observational and Pragmatic Research Institute (OPRI), Singapore.

University of Kentucky Markey Cancer Center researchers have discovered a genetic biomarker that could help identify patients with glioblastoma most likely to benefit from the cancer drug bevacizumab.

Researchers at UT Southwestern Medical Center have discovered how a hormone interacts with a receptor on the surface of immune cells to shield cancer cells from the body's natural defenses.

A new study led by Stephen D. Nimer, M.D., director of Sylvester Comprehensive Cancer Center, part of the University of Miami Miller School of Medicine, shows how a key molecule regulates the generation of new blood cells, a process called hematopoiesis that goes awry in cancer.

Sexually transmitted infections are on the rise in Texas. And in some parts of the state, the numbers are climbing higher than the national average.

Clock genes are a set of genes known to contribute to the regulation of the human body's internal 24-hour cycle, also known as the circadian rhythm. One of these genes is the so-called CLOCK gene, a protein that regulates the activity of other genes, contributing to recurrent patterns of sleep and wakefulness.

Measles cases in California and the United States are climbing to levels the country hasn't seen in years.