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Treatments for cancer are continuously improving, but they can still cause debilitating, even fatal, side effects. Immune checkpoint inhibitors, or ICIs, have revolutionized cancer therapy, yet their use can trigger a rare but deadly side effect that affects the heart: myocarditis. ICI-related myocarditis has a mortality of up to 40%.
Tuberculosis (TB) remains a major global health challenge, affecting more than 10 million people annually worldwide, with 1.25 million people dying of TB every year. While steroids like dexamethasone are used in certain TB cases (e.g., TB meningitis), their impact on immune cells is not well understood.
Researchers have adapted a rapid diagnostic technology that is able to identify undetected cases of malaria, helping tackle the spread of disease.
School is in session, and viral illness is on the rise. A new study suggests that lowering exposure to respiratory viruses in classrooms isn't as simple as adding high-efficiency particulate air (HEPA) purifiers to the room.
Scientists have identified an unusual type of brain cell that may play a vital role in progressive multiple sclerosis (MS), likely contributing to the persistent inflammation characteristic of the disease.
A new tool developed by Weill Cornell Medicine and the University of Adelaide investigators has enhanced the ability to track multiple gene mutations while simultaneously recording gene activity in individual cancer cells. The technology, which can now use diverse types of pathology samples and quickly process large numbers of cells, has enabled the investigators to glean new insights into how cancers evolve toward greater aggressiveness and therapy resistance.
Researchers led by Hokto Kazama at the RIKEN Center for Brain Science (CBS) in Japan have discovered how animals sense whether things smell pleasant or unpleasant, one of the abilities that allow us to appreciate the flavor of foods.
A recent study found that mold damage in school buildings does not increase the risk of asthma among students. The study included 110 Finnish primary and secondary schools, and the health of 30,000 students was tracked using national health registers over a 16-year period. The work is published in the journal PLOS One.
Chinese researchers have developed a novel method to efficiently engineer natural killer (NK) cells for cancer immunotherapy. NK cells are central to early antiviral and anticancer defense—among other immune system roles—making them well-suited for cancer immunotherapy. For example, chimeric antigen receptor (CAR)-NK therapy involves adding a lab-built receptor (a CAR) to an NK cell, enabling it to recognize a specific antigen on a cancer cell and attack it.
New research from the University of Adelaide has explored the genomic links within the index used to measure healthy aging—intrinsic capacity (IC), paving the way for potential targeted interventions.
The body's tissues can get injured in many ways, but while some injuries heal perfectly, others don't heal at all. A cut in the skin, for example, usually heals all on its own, while internal organs, such as the heart after a heart attack or the kidney after an acute injury, remain damaged, leading to diminished function. Most tissues of the body repair themselves using the same processes, but until now, drugs that target these pathways to enhance tissue repair in slow-healing organs have not been identified. That's about to change.
In the fall of 2022, hospitals across the U.S. saw a severe spike in cases of influenza, SARS-CoV-2, and respiratory syncytial virus (RSV), a phenomenon that became known as the "tripledemic."
UVA Health lung researchers are developing a promising approach to detecting patients at risk of interstitial lung disease (ILD), an increasingly common condition that is a leading reason for lung transplants. The approach could accelerate the development of new and better treatments with more tolerable side effects than existing options.
A major U.K. study of more than 165,000 dementia patients has found that risperidone raises stroke risk without exception, challenging safety assumptions by leaving no "safe group."
Low-dose IV infusions of ketamine are safe and effective in treating chronic pain, a new study says.
Stiff knees, aching hips and the slow grind of chronic joint pain are often accepted as an unavoidable part of getting older. But while osteoarthritis is the world's most common joint disease, experts say the way we treat and prevent it is badly out of step with the evidence.
Suicide is often thought of as the result of mental health struggles; however, over half of people who die by suicide do not have a known prior mental health condition. Many of these people die on their first suicide attempt, sometimes with little or no indication to those around them that they are considering ending their life.
Scientists in the United Kingdom say they have developed a blood test that can diagnose myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) with 96% accuracy—the first of its kind.
Baby boy Cassian is an internet sensation. He was born earlier in 2025 in the United States weighing 5.8 kilograms. But after his mom and the hospital shared the news recently, it wasn't long before headlines about the "giant" baby spread around the world. These included: "Are you OK?": Woman breaks record with giant newborn baby: Record-breaking baby tips the scales at almost double the average size of a newborn.