Targeted steroid use may offer a universal complementary treatment to fight TB

The aim of immunotherapy strategies is to leverage cells in the patient's own immune system to destroy tumor cells. Using a preclinical model, scientists from the Institut Pasteur and Inserm successfully stimulated an effective anti-tumor immune response by reprogramming the death of malignant B cells. They demonstrated an effective triple-therapy approach for treating forms of blood cancer such as certain lymphomas and leukemias which affect B cells. The study was published on August 15 in the journal Science Advances.

Aging is a systemic process that affects the entire body. Visible external signs of aging usually correspond to evidence of equivalent aging in the functioning of the internal organs. This indicates that skin cells age in tandem with other cells throughout the body, suggesting a mechanism whereby aging in one part of the body spreads systemically.

What was once tossed into compost bins could soon help grow stronger crops and even support human health, new research suggests.

A new at-home version of a common heart failure drug could make treatment easier for millions of Americans.

Stress sensitivity increases the frequency, intensity, and variability of suicidal thoughts among the university community. These are the findings of a longitudinal study coordinated by the Hospital del Mar Research Institute and Pompeu Fabra University, which analyzed survey data from more than 700 university students.

AI can be used to detect cervical cancer in women in resource-limited parts of the world. However, for this method to work, investments are needed in health care staff, reliable supply chains and trust in these communities. This has been shown in a new study from Uppsala University, Karolinska Institutet and the University of Helsinki, where researchers tested an AI-supported diagnostic method at rural hospitals in Kenya and Tanzania.

Nearly one in seven people live with a mental health disorder, making it one of the world's most pressing health challenges. Yet despite available treatments, most people still lack access to effective care.

A 6-year cohort study conducted by researchers from Japan, comprising nearly 39,000 older adults found that people living in rental flats and owner-occupied detached houses face higher risks of cardiovascular death compared with those in owner-occupied flats. The study attributes the increased risk to colder, less stable indoor temperatures in these housing types and suggests that improving housing quality to address these issues could lower cardiovascular mortality, particularly among men.

Treatments for cancer are continuously improving, but they can still cause debilitating, even fatal, side effects. Immune checkpoint inhibitors, or ICIs, have revolutionized cancer therapy, yet their use can trigger a rare but deadly side effect that affects the heart: myocarditis. ICI-related myocarditis has a mortality of up to 40%.

Researchers have adapted a rapid diagnostic technology that is able to identify undetected cases of malaria, helping tackle the spread of disease.

School is in session, and viral illness is on the rise. A new study suggests that lowering exposure to respiratory viruses in classrooms isn't as simple as adding high-efficiency particulate air (HEPA) purifiers to the room.

Scientists have identified an unusual type of brain cell that may play a vital role in progressive multiple sclerosis (MS), likely contributing to the persistent inflammation characteristic of the disease.

A new tool developed by Weill Cornell Medicine and the University of Adelaide investigators has enhanced the ability to track multiple gene mutations while simultaneously recording gene activity in individual cancer cells. The technology, which can now use diverse types of pathology samples and quickly process large numbers of cells, has enabled the investigators to glean new insights into how cancers evolve toward greater aggressiveness and therapy resistance.

Researchers led by Hokto Kazama at the RIKEN Center for Brain Science (CBS) in Japan have discovered how animals sense whether things smell pleasant or unpleasant, one of the abilities that allow us to appreciate the flavor of foods.

A recent study found that mold damage in school buildings does not increase the risk of asthma among students. The study included 110 Finnish primary and secondary schools, and the health of 30,000 students was tracked using national health registers over a 16-year period. The work is published in the journal PLOS One.

Chinese researchers have developed a novel method to efficiently engineer natural killer (NK) cells for cancer immunotherapy. NK cells are central to early antiviral and anticancer defense—among other immune system roles—making them well-suited for cancer immunotherapy. For example, chimeric antigen receptor (CAR)-NK therapy involves adding a lab-built receptor (a CAR) to an NK cell, enabling it to recognize a specific antigen on a cancer cell and attack it.

New research from the University of Adelaide has explored the genomic links within the index used to measure healthy aging—intrinsic capacity (IC), paving the way for potential targeted interventions.

The body's tissues can get injured in many ways, but while some injuries heal perfectly, others don't heal at all. A cut in the skin, for example, usually heals all on its own, while internal organs, such as the heart after a heart attack or the kidney after an acute injury, remain damaged, leading to diminished function. Most tissues of the body repair themselves using the same processes, but until now, drugs that target these pathways to enhance tissue repair in slow-healing organs have not been identified. That's about to change.