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Genomic testing aids precision therapy and tissue of origin identification for cancers whose primary site is unknown

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  • 2025-05-21 02:32 event
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Genomic testing aids precision therapy and tissue of origin identification for cancers whose primary site is unknown
A new study highlights the potential of whole genome and transcriptome sequencing (WGTS) to improve precision treatment and identify the tissue of origin for cancers whose primary site is unknown, also called cancers of unknown primary (CUP).

34. Study finds alarming rates of anxiety and depression in children with long COVID

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A new study from the Kennedy Krieger Institute is calling attention to an emerging mental health crisis among children with long COVID. Researchers found that nearly 40% of pediatric patients with long COVID reported feeling significant symptoms of anxiety or depression.

35. AI's usefulness in emergency room diagnoses is limited to presentation of typical symptoms, researchers find

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Artificial intelligence tools can assist emergency room physicians in accurately predicting disease, but only for patients with typical symptoms, West Virginia University scientists have found.

36. A study in stroke patients shows the brain's vision-language connection shapes object knowledge

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Our ability to store information about familiar objects depends on the connection between visual and language-processing regions in the brain, according to a study published in PLOS Biology by Bo Liu from Beijing Normal University, China, and colleagues.

37. Possible plastic contamination prompts nationwide ice cream recall

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Nearly 18,000 tubs of ice cream and frozen yogurt have been recalled because they may contain plastic pieces.

38. How mindfulness therapy could help those left behind by depression treatment

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For some people, depression is like an unwanted guest who moves in and refuses to leave. Even with therapy and medication, the heavy fog of low mood, exhaustion and hopelessness never fully lifts for long. For around 30% of people with depression, this is a daily reality.

39. Fluoride bans in public water systems threaten oral health of rural and low-income kids, pediatrician warns

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Florida recently became the second state to sign into law a ban on fluoride in public water systems, joining a wave of local and statewide efforts to restrict community fluoridation. The policy takes effect in July 2025. Meanwhile, FDA announced last week plans to remove ingestible fluoride supplements for children from the market.

40. Women whose sisters had postpartum psychosis are over 10 times as likely to experience it themselves

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Mount Sinai researchers have found for the first time that a woman is more than 10 times more likely to develop postpartum psychosis if her sister had experienced the condition, compared to a woman with a sister who did not.

41. Gut microbes may help protect patients from chemotherapy side effects

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Chemotherapy doesn't just kill cancer cells. It also affects the microbes in the digestive tract. Researchers at UC San Francisco have discovered that some gut bacteria can reduce the side effects of these potent treatments, and that one family of cancer drugs may actually boost these protective bacteria.

42. CRISPR study reveals mitochondrial dysfunction as early marker in amyotrophic lateral sclerosis

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Using the gene scissors CRISPR and stem cells, researchers at Stockholm University and the UK Dementia Research Institute (UK DRI) at King's College London have managed to identify a common denominator for different gene mutations that all cause the neurological disease amyotrophic lateral sclerosis (ALS). The research shows that ALS-linked dysfunction occurs in the energy factories of nerve cells, the mitochondria, before the cells show other signs of disease, which was not previously known. The study was recently published in the journal Nature Communications.

43. Genomic testing aids precision therapy and tissue of origin identification for cancers whose primary site is unknown

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A new study highlights the potential of whole genome and transcriptome sequencing (WGTS) to improve precision treatment and identify the tissue of origin for cancers whose primary site is unknown, also called cancers of unknown primary (CUP).

44. Guidance on using Apple Watch for heart health monitoring helps patients and clinicians

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The American College of Cardiology (ACC) has issued a guidance tool to help clinicians and patients use health data collected while wearing an Apple Watch to effectively track and manage cardiovascular health.

45. Undervalued nursing staff say doing 'box-ticking' exercises is forcing them out, according to study

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A lack of recognition and the de-professionalization of nursing is driving many to leave the profession in significant numbers, according to the findings of a new study.

46. US to limit COVID boosters to over-65s or those at high risk

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The United States will restrict routine COVID-19 boosters to people over 65 or those at higher risk of serious illness, while requiring new placebo-controlled trials to justify vaccination in healthy individuals under that age, senior officials said Tuesday.

47. Markers in blood and urine may reveal how much ultra-processed food we are eating

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Molecules in blood and urine may reveal how much energy a person consumes from ultra-processed foods, a key step to understanding the impact of the products that make up nearly 60% of the American diet, a new study finds.

48. Publix recalls baby food over possible lead contamination

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Publix is recalling one of its popular GreenWise baby food pouches because it may contain lead, the company said this week.

49. CAR-T cell therapy is revolutionizing cancer treatment. Here's how it works

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Personalized medicine is already a reality in clinical practice, and CAR-T cell therapy is one of its most promising tools. This innovative approach, which involves genetically modifying the cells of the immune system, is transforming the way we treat not only cancer, but also other diseases.

50. The DIY guide to checking how well you're aging

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A few years ago, a social media trend challenged people to see if they could stand up from the floor without using their hands. Now, it's all about how long you can balance on one leg while brushing your teeth. These quirky "tests" promise to tell us how well we're aging—but do they really?

51. Investigating gender differences in primary care physician earnings and outcomes

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Despite often achieving better patient outcomes, women primary care physicians (PCPs) face a significant and ongoing wage gap compared to their male counterparts. This disparity is partly due to volume-based payment models, where doctors are compensated per visit or service. Women PCPs typically spend additional time caring for patients during and in-between doctor's visits, leading to a greater share of their work going unpaid.

52. World Health Assembly adopts historic Pandemic Agreement to make the world more equitable and ...

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20 May 2025 Agreement’s adoption follows three years of intensive negotiation launched due to gaps and inequities identified in national and global COVID-19 response. Agreement boosts global collabo

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