Human liver organoid platform can predict immune-mediated drug toxicity

When we hear the word "twins," we tend to think of two identical people who share physical traits, and perhaps certain behaviors or quirks. However, in the world of technology this word has a different meaning. It refers to something both revolutionary and still relatively underexplored: digital twins.

Researchers at NYU Abu Dhabi (NYUAD) have developed a new type of brain implant that can deliver drugs to multiple regions of the brain with high precision, offering fresh possibilities for the treatment of neurological disorders.

Layoff notices to some 740 workers at the U.S. Centers for Disease Control and Prevention (CDC) have been rescinded.

Scientists have discovered a method to induce human endothelial cells from a small biopsy sample to multiply in the laboratory, producing more than enough cells to replace damaged blood vessels or nourish organs for transplantation, according to a preclinical study by Weill Cornell Medicine investigators.

Plant-based materials have traditionally been used to treat a variety of viral infections. Now, researchers have found that cardamom seed extract, as well as its main bioactive ingredient, 1,8-cineole, can have potent antiviral effects through its ability to enhance the production of antiviral molecules known as type I interferons via nucleic acid "sensors" inside cells.

The brain's mechanisms for repairing injuries caused by trauma or degenerative diseases are not yet known in detail. Now, a study from the University of Barcelona describes a new strategy based on stem cell therapy that could enhance neuronal regeneration and neuroplasticity when this vital organ is damaged.

Nervous system functions, from motion to perception to cognition, depend on the active zones of neural circuit connections (synapses) sending out the right amount of their chemical signals at the right times. By tracking how synaptic active zones form and mature in fruit flies, researchers at The Picower Institute for Learning and Memory at MIT have revealed a fundamental model for how neural activity during development builds properly working connections.

How can clinical guidelines be designed in such a way that they enable (contextually) equitable and inclusive health care—and at the same time promote research and innovation in a targeted manner? Professor Dr. Sabine Oertelt-Prigione, head of the Sex- and Gender-sensitive Medicine working group, and her colleagues discuss these questions in the Perspective article "Designing clinical practice guidelines for equitable, inclusive, and contextualized care."

A first-of-its-kind clinical study shows that offering modest monthly grocery cards for produce leads to improvements in blood pressure compared to distributing pre-selected boxes of healthy food.

South Africa's health minister on Tuesday called lenacapavir, the first twice-yearly HIV prevention jab in the world, a "groundbreaking" tool to fight the disease, but warned initial donated supply would be limited to nearly half a million people in the African country with the highest prevalence rate.

A new study led by researchers at the George Washington University and published through the DC Cohort, one of the largest HIV longitudinal studies in the United States, finds that nearly half of people living with HIV experience skin conditions—even in the modern era of highly effective antiretroviral therapy.

Among U.S. military personnel and veterans reporting recent suicidal ideation and/or suicidal behaviors, brief cognitive behavioral therapy (BCBT) reduces suicide attempts, according to a study published online Sept. 25 in JAMA Psychiatry.

Faulty versions of the LMNA gene can cause a wide range of health problems, including heart muscle disease (dilated cardiomyopathy) and muscle weakness (muscular dystrophies). Many of these diseases are caused by single-point mutations, which are changes to one DNA "letter" (base). Treatments include physical therapy and lifelong medication, but there are currently no cures. That could change following the work of a team of scientists who have developed and successfully tested a gene editing technique to correct the underlying genetic mutations.

The U.S. Food and Drug Administration has approved Jascayd (nerandomilast) tablets to treat idiopathic pulmonary fibrosis (IPF).

A University of Alberta research team has uncovered a new role for a genetic mutation previously known to be linked to developmental disorders—and it could hold the key to more effective treatments and improved outcomes for cancer patients.

A National Taiwan University (NTU) interdisciplinary research team, led by Prof. Chi-Kuang Sun and Prof. Tzung-Dau Wang, has unveiled a optical imaging technique that enables the reconstruction of an individual's historical blood glucose patterns—information that has long been beyond the reach of current medical technology.

Children living near the Salton Sea, in Southern California's desert region of Imperial County, are experiencing poorer lung function than children exposed to less wind-blown dust, according to a new study led by researchers at the University of California, Irvine's Joe C. Wen School of Population & Public Health.

A McGill University-led clinical trial is the first in humans to show online brain training exercises can improve brain networks affecting learning and memory.