Precise gene editing technique changes one DNA base to correct heart disease

Plant-based materials have traditionally been used to treat a variety of viral infections. Now, researchers have found that cardamom seed extract, as well as its main bioactive ingredient, 1,8-cineole, can have potent antiviral effects through its ability to enhance the production of antiviral molecules known as type I interferons via nucleic acid "sensors" inside cells.

The brain's mechanisms for repairing injuries caused by trauma or degenerative diseases are not yet known in detail. Now, a study from the University of Barcelona describes a new strategy based on stem cell therapy that could enhance neuronal regeneration and neuroplasticity when this vital organ is damaged.

Nervous system functions, from motion to perception to cognition, depend on the active zones of neural circuit connections (synapses) sending out the right amount of their chemical signals at the right times. By tracking how synaptic active zones form and mature in fruit flies, researchers at The Picower Institute for Learning and Memory at MIT have revealed a fundamental model for how neural activity during development builds properly working connections.

How can clinical guidelines be designed in such a way that they enable (contextually) equitable and inclusive health care—and at the same time promote research and innovation in a targeted manner? Professor Dr. Sabine Oertelt-Prigione, head of the Sex- and Gender-sensitive Medicine working group, and her colleagues discuss these questions in the Perspective article "Designing clinical practice guidelines for equitable, inclusive, and contextualized care."

A first-of-its-kind clinical study shows that offering modest monthly grocery cards for produce leads to improvements in blood pressure compared to distributing pre-selected boxes of healthy food.

Researchers at Cincinnati Children's Hospital Medical Center in collaboration with Roche, have developed a next-generation human liver organoid microarray platform that could help predict which drugs may cause harmful immune reactions in some people.

South Africa's health minister on Tuesday called lenacapavir, the first twice-yearly HIV prevention jab in the world, a "groundbreaking" tool to fight the disease, but warned initial donated supply would be limited to nearly half a million people in the African country with the highest prevalence rate.

A new study led by researchers at the George Washington University and published through the DC Cohort, one of the largest HIV longitudinal studies in the United States, finds that nearly half of people living with HIV experience skin conditions—even in the modern era of highly effective antiretroviral therapy.

Among U.S. military personnel and veterans reporting recent suicidal ideation and/or suicidal behaviors, brief cognitive behavioral therapy (BCBT) reduces suicide attempts, according to a study published online Sept. 25 in JAMA Psychiatry.

The U.S. Food and Drug Administration has approved Jascayd (nerandomilast) tablets to treat idiopathic pulmonary fibrosis (IPF).

A University of Alberta research team has uncovered a new role for a genetic mutation previously known to be linked to developmental disorders—and it could hold the key to more effective treatments and improved outcomes for cancer patients.

A National Taiwan University (NTU) interdisciplinary research team, led by Prof. Chi-Kuang Sun and Prof. Tzung-Dau Wang, has unveiled a optical imaging technique that enables the reconstruction of an individual's historical blood glucose patterns—information that has long been beyond the reach of current medical technology.

Children living near the Salton Sea, in Southern California's desert region of Imperial County, are experiencing poorer lung function than children exposed to less wind-blown dust, according to a new study led by researchers at the University of California, Irvine's Joe C. Wen School of Population & Public Health.

A McGill University-led clinical trial is the first in humans to show online brain training exercises can improve brain networks affecting learning and memory.

A multicenter study led by London Health Sciences Centre Research Institute (LHSCRI), Lawson Research Institute of St. Joseph's Health Care London (Lawson), and University Health Network (UHN) has found a novel imaging solution, called prostate-specific membrane antigen (PSMA) positron emission tomography (PET) scanning, can more effectively detect the recurrence of prostate cancer compared to standard imaging methods, and is associated with improved survival outcomes. The study, carried out over seven years, is published in The Journal of Nuclear Medicine.

A research team from the Cognitive Neurotechnology Unit and the Visual Perception and Cognition Laboratory at Toyohashi University of Technology has found that approach–avoidance behavior in a virtual reality (VR) environment modulates how individuals recognize facial expressions. Notably, the study demonstrated that participants were more likely to perceive a facial expression as "angry" when they actively moved away from the face stimulus than when the face moved away from them. These findings contribute to a better understanding of the reciprocal relationship between perception and action in social contexts.

Since ancient times, it was thought that painful stomach ulcers were caused by eating spicy foods or having an unhealthy diet. But since then, researchers have found that Helicobacter pylori—a common bacterium found in over 60% of the world's population—was the real culprit behind most stomach ulcers and a high risk for stomach cancer.

The same chemical reaction that makes a piece of freshly toasted bread delicious also happens in our bodies, with far less appetizing consequences. We're talking about the Maillard reaction, where sugars react with protein to form brown, sticky compounds in a process called glycation. Glycation is increasingly suspected to be a hidden driver of obesity, diabetes and accelerated aging. Researchers in the Kapahi lab have found a way to tame it in mice by feeding them a combination of glycation-lowering compounds.