Imaging study reveals how tiny brain vessels pulse to regulate blood flow

One of the largest Brazilian studies on colorectal cancer has revealed how genetic variations and genetic ancestry can influence the risk of developing the disease. The study, conducted by researchers at Hospital de Amor (formerly Hospital de Câncer de Barretos, in the interior of the state of São Paulo) and other institutions, contributes to understanding the complex genetic reality of a highly mixed population such as Brazil's. It was published in the journal JCO Global Oncology.

Antibodies are the critical targeting agents of the immune system and the crux of immune therapy and vaccine development, but studying them is slow, expensive and labor-intensive. Now, researchers at the University of Illinois Urbana-Champaign have developed a new high-volume method that can rapidly build and test large numbers of antibodies at once. With it, they have already uncovered common aspects of how antibodies bind across variants of a key influenza target protein.

In Brazil, researchers at São Paulo State University (UNESP) conducted experiments on rats and identified that a protein-deficient diet during pregnancy and breastfeeding can compromise the reproductive health of male offspring. A study published in the journal Biology Open found that maternal protein restriction causes changes in the structure and function of the epididymis, an organ in the reproductive system responsible for the maturation and storage of sperm.

A research team led by Prof. Wang Huanqin at the Institute of Intelligent Machines, the Hefei Institutes of Physical Science of the Chinese Academy of Sciences, recently proposed a semi-supervised medical image segmentation method.

Available on demand, in abundance and containing multiple biomarkers, sweat is an increasingly appealing medium for monitoring health, according to researchers at Penn State. But not everyone—especially critically ill patients—can build up enough sweat to provide a robust enough sample for current analysis techniques.

Some sugar substitutes may come with unexpected consequences for long-term brain health, according to a study published in Neurology. The study examined seven low- and no-calorie sweeteners and found that people who consumed the highest amounts experienced faster declines in thinking and memory skills compared to those who consumed the lowest amounts.

The body has an intricate system to defend against infections where each type of immune cell plays a distinct role. Now, a study led by researchers from the Penn State College of Medicine has uncovered a new function of the immune cells that are known for making antibodies. They determined that in response to flu infection, a specialized set of B cells produce a key signaling molecule that the immune system needs to develop a robust, long-term response to fight off infections.

A University of Cologne research team has identified a direct molecular link between aging and neurodegeneration by investigating how age-related changes in cell signaling contribute to toxic protein aggregation.

Mayo Clinic researchers have pinpointed how excessive alcohol consumption contributes to fatty liver disease, a condition that affects more than one in three people in the U.S.

Macquarie University hearing researchers have discovered how our brains learn to listen, and how this can help us understand speech in noisy, echo-filled spaces.

Scientists from Duke-NUS Medical School, in collaboration with researchers in Nepal, have found that waning immunity to Japanese encephalitis virus (JEV) may increase the risk of more severe dengue disease in humans.

Imagine someone you care about suddenly experiencing chest pain, turning pale, and breathing heavily. These are some of the symptoms of a heart attack.

A Spanish study shows that patients with genetic dilated cardiomyopathy who experience severe arrhythmias are at an elevated risk of developing advanced heart failure and requiring a heart transplant.

Bipolar disorder (BD) is a chronic mental health condition characterized by recurrent episodes of depression and mania. It poses a substantial burden on global health, with an increasing incidence. Despite its prevalence, there exists a significant gap in understanding the underlying neuropathological mechanisms.

A baby's focus may seem brief, but some words and gestures do a better job of keeping their attention on their surroundings even before they say their first word.

A Ph.D. student at the University of Bristol has developed a convenient and cost-effective wearable patch to measure subtle temperature changes across the breast, which could in future be used to detect potential abnormalities and cancerous tumors.

Pregnancy complications such as preeclampsia and preterm birth often arise during the late stage of pregnancy. However, researchers have primarily relied on placental cells from early pregnancy to study these conditions, which may not fully reflect the biology of late-stage complications.

A large-scale cross-sectional study of older individuals in the UK supports contextual, process-based models of mental health that emphasize values-guided behavior, psychosocial resources and biopsychosocial integration, according to a study published in the open-access journal PLOS Mental Health by Darren Edwards from Swansea University, UK, and colleagues.