Neurodegenerative disease-related proteins linked to bipolar disorder symptoms in key brain regions

Some sugar substitutes may come with unexpected consequences for long-term brain health, according to a study published in Neurology. The study examined seven low- and no-calorie sweeteners and found that people who consumed the highest amounts experienced faster declines in thinking and memory skills compared to those who consumed the lowest amounts.

The body has an intricate system to defend against infections where each type of immune cell plays a distinct role. Now, a study led by researchers from the Penn State College of Medicine has uncovered a new function of the immune cells that are known for making antibodies. They determined that in response to flu infection, a specialized set of B cells produce a key signaling molecule that the immune system needs to develop a robust, long-term response to fight off infections.

A University of Cologne research team has identified a direct molecular link between aging and neurodegeneration by investigating how age-related changes in cell signaling contribute to toxic protein aggregation.

Mayo Clinic researchers have pinpointed how excessive alcohol consumption contributes to fatty liver disease, a condition that affects more than one in three people in the U.S.

For more than a century, scientists have known that blood vessels can rhythmically contract and relax in a process called vasomotion. In the brain, these subtle oscillations are thought to help fine-tune blood flow and may play a role in clearing waste products. Disruptions in vasomotion have been linked to disorders such as Alzheimer's disease and stroke, but the details of how these vessel dynamics arise and spread have remained unclear.

Macquarie University hearing researchers have discovered how our brains learn to listen, and how this can help us understand speech in noisy, echo-filled spaces.

Scientists from Duke-NUS Medical School, in collaboration with researchers in Nepal, have found that waning immunity to Japanese encephalitis virus (JEV) may increase the risk of more severe dengue disease in humans.

Imagine someone you care about suddenly experiencing chest pain, turning pale, and breathing heavily. These are some of the symptoms of a heart attack.

A Spanish study shows that patients with genetic dilated cardiomyopathy who experience severe arrhythmias are at an elevated risk of developing advanced heart failure and requiring a heart transplant.

A baby's focus may seem brief, but some words and gestures do a better job of keeping their attention on their surroundings even before they say their first word.

A Ph.D. student at the University of Bristol has developed a convenient and cost-effective wearable patch to measure subtle temperature changes across the breast, which could in future be used to detect potential abnormalities and cancerous tumors.

Pregnancy complications such as preeclampsia and preterm birth often arise during the late stage of pregnancy. However, researchers have primarily relied on placental cells from early pregnancy to study these conditions, which may not fully reflect the biology of late-stage complications.

A large-scale cross-sectional study of older individuals in the UK supports contextual, process-based models of mental health that emphasize values-guided behavior, psychosocial resources and biopsychosocial integration, according to a study published in the open-access journal PLOS Mental Health by Darren Edwards from Swansea University, UK, and colleagues.

In the U.K., four in 10 citizens identify as being lonely at least some of the time, and people who report being often lonely incur about £850 more in annual National Health Service costs than their non-lonely counterparts, according to a study published in the open-access journal PLOS One by Nia Morrish from the University of Exeter, U.K., and colleagues.

A new study reveals the profound emotional and physical toll of extreme morning sickness, with more than half of affected women reporting they considered terminating their pregnancy, and nine in 10 saying they had thought about not having more children.

Survey participants who reported using a smartphone while on the toilet had a higher risk of hemorrhoids than non-users. Chethan Ramprasad of Beth Israel Deaconess Medical Center, U.S., and colleagues present these findings in a new study in the open-access journal PLOS One.

A new study led by the University of Portsmouth suggests our saliva is stronger than we thought. The research, published in PLOS One, is the first to examine how drinking apple juice affects saliva's lubricating properties using advanced scientific techniques.

Individuals with an increased risk of dementia due to Alzheimer's disease may have impaired spatial orientation skills. DZNE researchers have come to this conclusion based on a study involving around 100 older adults who were tasked with determining their position within a virtual environment.