Key protein complex drives nerve cell death in Alzheimer's disease, study finds

A recent systematic review and meta-analysis conducted by researchers from the Research Institute of the McGill University Health Center (The Institute) and published in eClinicalMedicine reveals that children of mothers with gestational diabetes or fathers with type 2 diabetes have higher chances of developing type 1 diabetes than kids whose parents do not have any type of diabetes. The study provides insights that could help doctors identify at-risk children earlier.

Younger adults who experience frailty face a higher risk of death and emergency hospital admission, according to new University of Dundee research published in The Lancet Healthy Longevity. The study, led by Dr. Daniel Morales from the University's School of Medicine, explored whether the electronic frailty index (eFI), which is already used for older adults, could also identify vulnerable younger people who might benefit from early support.

Blood contains two types of neutrophils, a type of white blood cell: mature neutrophils and immature neutrophils. Under normal conditions, most neutrophils are mature and play a role in host defense by inducing inflammation in response to pathogens.

A team of researchers led by Professor Yoko Hamazaki and Assistant Professor Yann Pretemer (Department of Life Science Frontiers) has developed an in vitro model that faithfully recapitulates human thymic epithelial cell (TEC) development using iPS cells. The results are published in Nature Communications.

With parents and teachers preparing for the return to classroom routines, Brock experts say fostering students' physical and mental health is key for maximum learning and growth.

We all know how much better we feel after a good night's sleep. Science backs this up: high-quality sleep boosts cardiovascular health, immune function, brain health and emotional well-being. Unsurprisingly, many people are keen to improve their sleep—and "sleep hygiene" has become a go-to strategy.

Scientists from EPFL and Haute École d'Ingénierie et de Gestion du Canton de Vaud (HEIG-VD), working in partnership with the City of Yverdon-les-Bains, have analyzed the sleep quality of a sample of the city's residents. They discovered that sleep disorders are much more common there than elsewhere in the country.

Forskolin, a natural compound derived from a plant, could significantly improve treatment outcomes for an aggressive form of leukemia, known as KMT2A-rearranged Acute Myeloid Leukemia (KMT2A-r AML), according to a new study from the University of Surrey.

Researchers at Baylor College of Medicine have developed an artificial intelligence (AI) model that reveals how protein modifications link genetic mutations to disease. The method, called DeepMVP and published in Nature Methods, significantly outperforms previously published models and has implications for the development of novel therapeutics.

Within the next few years, doctors may be able to spot signs of Alzheimer's disease and other dementias using routine eye exams well before symptoms appear, a new study suggests.

The percentage of young and midlife adults using nicotine pouches significantly increased last year, while cannabis use, vaping and the use of psychedelic drugs are at or near all-time highs, according to the latest data from the University of Michigan's Monitoring the Future Panel survey.

Researchers have successfully produced antibodies that kill the parasite carried by the "kissing bug" that causes the potentially deadly Chagas disease. The research is a vital step toward the development of the first effective vaccine.

Researchers at Osaka Metropolitan University have found that changing the timing of fertility drugs to match the follicle maturity period significantly increases the number of ovulated oocytes—the cells that develop into eggs—during artificial fertilization, even in rats that typically produce few oocytes. The study was published in Heliyon.

A recent study has developed a highly accurate risk prediction framework for preterm birth (PTB) that could broaden the potential of AI-driven multi-omics applications in precision obstetrics and biomedical research.

University of Cambridge researchers report that inactivating dorsolateral prefrontal cortex area 46 in marmosets blunts appetitive motivation and heightens threat reactivity, with effects mediated through asymmetric left-hemisphere pathways.

Scientists have discovered how mutations in a specific gene drive the rare developmental disorder Weaver syndrome, which is marked by intellectual disability and overgrowth and predisposes people with the condition to cancer. Their work has additional relevance for a growing suite of related diseases and provides important insights that may one day lead to improved therapies.

UCLA scientists have developed the first comprehensive road map showing how the ovarian reserve forms in primates, providing crucial insights into women's health that could revolutionize treatments for infertility and hormonal disorders such as polycystic ovary syndrome, or PCOS.

People with type 2 obesity-driven diabetes tend to have more aggressive breast cancers, but no one knows exactly why. A new study by researchers at Boston University Chobanian & Avedisian School of Medicine and published in Communications Biology found that tiny particles in the blood, known as exosomes, which are altered by diabetes, can reprogram immune cells inside tumors, making them weaker and allowing the cancer to grow and spread more easily.