Microglia replacement halts progression of rare genetic brain disease in mice and humans

Researchers from the University of Maryland's Department of Nutrition and Food Science are shedding new light on how a dangerous food-borne pathogen—Cronobacter sakazakii—may have adapted to thrive in dried and powdered foods across the global supply chain.

When a child struggles to tie their shoelaces, write legibly or stay upright during PE, it can be dismissed as clumsiness or lack of effort. But for around 5% of UK children, these challenges stem from a neurodevelopmental condition known as developmental coordination disorder (DCD), also known as dyspraxia. And new findings reveal how deeply it's impacting their lives—at home, in school and in their future.

As the popularity of medications for weight loss, such as Ozempic and Wegovy, surges across North America, new research raises important concerns about their use among adolescent boys and young men.

A new study led by investigators at the UCLA Health Jonsson Comprehensive Cancer Center may help explain why certain liver tumors return quickly after thermal ablation, a widely used minimally-invasive, image-guided technique that kills cancer cells by applying intense heat through a needle-like probe.

Our genes underlie all aspects of life, from our looks to how our cells behave. This includes diseases, as genetic changes can underlie the development and progression of certain health problems. This is true for arteriovenous malformations (AVMs), vascular anomalies that are known to be life-threatening. However, the biological mechanisms driving their growth have remained unclear until now.

More than half of people who have given birth are not using contraception two months later despite the risk that back-to-back pregnancies can pose, a new UCL study shows.

Recent headlines in the United Kingdom earlier this year attributed noise-canceling headphones as a possible culprit in rising rates of auditory processing disorder (APD) and hearing problems in younger populations. While the APD theory is interesting, it's speculation that's not backed up by the data, according to a campus audiologist.

A nontargeted screening approach in the emergency department is superior to targeted screening for identifying new hepatitis C virus (HCV) infections, according to a study published online July 9 in the JAMA.

MIT researchers have developed a new bionic knee that can help people with above-the-knee amputations walk faster, climb stairs, and avoid obstacles more easily than they could with a traditional prosthesis. The work appears in Science.

In a follow-up analysis to the pivotal TOPAZ-1 study, which established the combination therapy of durvalumab (an immunotherapy drug) plus gemcitabine and cisplatin (GemCis, chemotherapy drugs) as the first-line treatment for people with advanced biliary tract cancer (aBTC), researchers have shown that after three years more than twice as many study participants treated with durvalumab plus GemCis had survived compared to those treated with a placebo plus GemCis.

Children with multiple long-term health issues undergo severe emotional stress at the same time as they are trying to cope with the physical challenges of their condition, a study published in the Journal of Affective Disorders has found.

Cambodia's Ministry of Health recently confirmed the country's twelfth human case of H5N1 avian influenza so far this year. The patient, a five-year-old boy from Kampot province, is currently in intensive care with severe respiratory symptoms.

A team has made a major breakthrough in the field of three-dimensional (3D) imaging of large-scale biological tissues. They developed the world's fastest high-definition 3D imaging technology for the entire body of small animals at subcellular resolution, enabling efficient mapping of the fine architecture of the peripheral nervous system (PNS). The findings were published in Cell.

Results of a Dana-Farber Cancer Institute-initiated phase 1 clinical trial for patients with melanoma show that an updated formula and delivery of the NeoVax personalized cancer vaccine called NeoVaxMI is safe, feasible, and improves the vaccine-specific immune response compared to previous trials of the platform.

A new wearable wristband could significantly improve diabetes management by continuously tracking not only glucose but also other chemical and cardiovascular signals that influence disease progression and overall health. The technology was published in Nature Biomedical Engineering.

Dr. Ho Sang Jung and his research team from the Advanced Bio and Healthcare Materials Research Division at the Korea Institute of Materials Science (KIMS) have developed an optical biosensor capable of detecting trace amounts of cancer cell DNA in the bloodstream with high sensitivity, enabling early cancer diagnosis.

Researchers at Karolinska Institutet have discovered a previously unknown molecule that may explain why people with type 2 diabetes often suffer from muscle weakness and muscle loss—a condition that has a major impact on quality of life and overall health.

A breast scan for detecting cancer takes less than a minute using an experimental system that combines photoacoustic and ultrasound imaging, according to a study in IEEE Transactions on Medical Imaging.