Mismatch repair germline pathogenic variants could predispose to uveal melanoma

Keeping a healthy mix of friendly microbes in the gut—known as eubiosis—is crucial for good health. When that delicate balance is thrown off—often by antibiotics, diet or illness—the result can be a range of issues, from digestive problems to more serious conditions like Crohn's disease, ulcerative colitis, and even neurological and metabolic disorders.

Among older adults, metabolic dysfunction-associated steatotic liver disease (MASLD) is associated with increased risk for sudden sensorineural hearing loss (SSNHL), according to a study published in the June issue of Laryngoscope: Investigative Otolaryngology.

Spending time outside walking, hiking or running is a great way to stay healthy during the summer. But before you jump into a new routine, health experts say it's important to take steps to stay safe and avoid injury.

23 June 2025, Dublin/Geneva—The World Health Organization (WHO) today released its report on the Global Tobacco Epidemic 2025 at the World Conference on Tobacco Control in Dublin, warning that action is needed to maintain and accelerate progress in tobacco control as rising industry interference challenges tobacco policies and control efforts. The report focuses on the six proven WHO MPOWER tobacco control measures to reduce tobacco use, which claims over 7 million lives a year: Monitoring tobacco use and prevention policies; Protecting people from tobacco smoke with smoke-free air legislation; Offering help to quit tobacco use; Warning about the dangers of tobacco with pack labels and mass media; Enforcing bans on tobacco advertising, promotion and sponsorship; and Raising taxes on tobacco. Since 2007, 155 countries have implemented at least one of the WHO MPOWER tobacco control measures to reduce tobacco use at best-practice level. Today, over 6.1 billion people, three-quarters of the world’s population, are protected by at least one such policy, compared to just 1 billion in 2007. Four countries have implemented the full MPOWER package: Brazil, Mauritius, the Netherlands (Kingdom of the), and Türkiye. Seven countries are just one measure away from achieving the full implementation of the MPOWER package, signifying the highest level of tobacco control, including Ethiopia, Ireland, Jordan, Mexico, New Zealand, Slovenia and Spain. However, there are major gaps. Forty countries still have no MPOWER measure at best-practice level and more than 30 countries allow cigarette sales without mandatory health warnings. “Twenty years since the adoption of the WHO Framework Read more...

A team of international researchers led by scientists at City of Hope provides the most thorough account yet of an elusive target for cancer treatment. Published in Science Advances, the study suggests a complex signaling process involving paxillin, a focal adhesion protein that acts as a hub to connect with other proteins, may be vulnerable to therapy despite its fluid state.

It's difficult to overstate the corrosive impact of Canada's ongoing opioid crisis. Since 2016, there have been over 40,000 opioid-related deaths across the country, devastating Canadian families from all walks of life. Opioid-related hospitalizations and calls to paramedics have ballooned.

Cambodia registered its fifth bird flu death this year after a 52-year-old man died from the virus, the health ministry said on Saturday.

A French woman from the Caribbean island of Guadeloupe has been identified as the only known carrier of a new blood type, dubbed "Gwada negative," France's blood supply agency has announced.

22 June 2025, Cairo, Egypt – June is Alzheimer’s and Brain Awareness Month, dedicated to raising awareness about all forms of dementia. Worldwide, dementia is the seventh leading cause of death and a major contributor to disability. The majority (61%) of the 55 million people living with dementia – a number that is expected to increase to approximately 78 million by 2030 – live in low- and middle-income countries, underscoring the urgent need to raise awareness and advocate for better care, support and prevention strategies. In the World Health Organization (WHO) Eastern Mediterranean Region around 2.3 million people live with dementia, and it is the 14th leading cause of death. Dementia is an umbrella term for several diseases that affect memory and other cognitive abilities and behaviours that interfere with a person’s ability to maintain their daily activities. It is a progressive and chronic condition in which there is disturbance of brain functions such as memory, thinking, judgment, orientation, calculation, language, learning capacity and comprehension. It is often preceded by a decline in motivation, deteriorating social behaviour and emotional control. Alzheimer's disease is a specific type of dementia characterized by progressive memory loss and cognitive decline. While the strongest known risk factor for dementia is age it is not a normal part of ageing. Lack of awareness and understanding of dementia leads to stigmatization and barriers to diagnosis and proper care. The impact of dementia extends far beyond the person with dementia. Read more...

There are substantial racial and ethnic differences in U.S. adolescents' use of mental health services, according to a study published online June 18 in JAMA Network Open.

Some of the most harmful genetic changes in cancer are also the hardest to see. These structural alterations, deep within a tumor's DNA, can fuel aggressive growth and evade standard testing, especially when tissue samples are small or degraded.

The relationship between genetic variants and the risk of late-onset cardiomyopathy remains poorly understood in survivors of childhood cancer despite being otherwise well established. Scientists from St. Jude Children's Research Hospital have helped address this gap, assessing whether variant trends seen in the general population also apply to late-onset cardiomyopathy in five-year survivors of childhood cancer.

New research by Swansea University and Cambridge University has revealed the causes and devastating impacts of delays—that can last decades—in diagnosing lupus, an auto-immune condition.

The U.S. logged fewer than 20 measles cases this week, though Iowa announced the state's first outbreak Thursday and Georgia confirmed its second Wednesday.

Six in 10 dementia caregivers report having at least one modifiable risk factor that could increase their own chances of developing dementia, according to a report issued June 12 by the Alzheimer's Association.

The U.S. Food and Drug Administration has approved Andembry (garadacimab-gxii) as the only treatment targeting factor XIIa for prophylactic use to prevent attacks of hereditary angioedema (HAE).

A new generation of weight-loss drugs has proven remarkably effective, hugely popular and massively lucrative in the last few years, though they do have some drawbacks.

Pregnant women are exposed to lower levels of toxic chemicals if they vape during pregnancy compared with if they smoke cigarettes, according to new research led by scientists at City St George's, University of London and published today in Nicotine and Tobacco Research.