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Mismatch repair (MMR) germline alterations are enriched among patients with uveal melanoma (UM), according to a study published online June 18 in JAMA Ophthalmology.
There are substantial racial and ethnic differences in U.S. adolescents' use of mental health services, according to a study published online June 18 in JAMA Network Open.
Some of the most harmful genetic changes in cancer are also the hardest to see. These structural alterations, deep within a tumor's DNA, can fuel aggressive growth and evade standard testing, especially when tissue samples are small or degraded.
The relationship between genetic variants and the risk of late-onset cardiomyopathy remains poorly understood in survivors of childhood cancer despite being otherwise well established. Scientists from St. Jude Children's Research Hospital have helped address this gap, assessing whether variant trends seen in the general population also apply to late-onset cardiomyopathy in five-year survivors of childhood cancer.
New research by Swansea University and Cambridge University has revealed the causes and devastating impacts of delays—that can last decades—in diagnosing lupus, an auto-immune condition.
The U.S. logged fewer than 20 measles cases this week, though Iowa announced the state's first outbreak Thursday and Georgia confirmed its second Wednesday.
Six in 10 dementia caregivers report having at least one modifiable risk factor that could increase their own chances of developing dementia, according to a report issued June 12 by the Alzheimer's Association.
The U.S. Food and Drug Administration has approved Andembry (garadacimab-gxii) as the only treatment targeting factor XIIa for prophylactic use to prevent attacks of hereditary angioedema (HAE).
A new generation of weight-loss drugs has proven remarkably effective, hugely popular and massively lucrative in the last few years, though they do have some drawbacks.
Pregnant women are exposed to lower levels of toxic chemicals if they vape during pregnancy compared with if they smoke cigarettes, according to new research led by scientists at City St George's, University of London and published today in Nicotine and Tobacco Research.
A diabetes medication that lowers brain fluid pressure has cut monthly migraine days by more than half, according to a new study presented today at the European Academy of Neurology (EAN) Congress 2025.
A study conducted at the Department of Neurology, Inselspital, the University Hospital of Bern, analyzed 4,170 individuals over an observation period of 13,217 person-years. It found that heart rate variability (HRV) during sleep can serve as a powerful early warning sign of future health conditions, including stroke, depression, and cognitive dysfunction.
A new study reveals that when we experience short-term (acute) pain, the brain has a built‑in way to dial down pain signals—like pressing the brakes—to keep them from going into overdrive. But in long‑term (chronic) pain, this braking system fails, and the pain signals just keep firing. This discovery helps explain why some pain goes away while other pain lingers, and it opens the door to new treatments that could stop pain from becoming chronic in the first place.
The Simons Foundation Autism Research Initiative (SFARI) has released phenotypic and genetic data from the Autism Inpatient Collection (AIC), a cohort of more than 1,500 youth participants ages 4 to 20 years old who were hospitalized in one of six child psychiatry units in the United States. The AIC aimed to engage these individuals, many of whom meet recently proposed criteria for "profound autism" (autism characterized by intellectual disability or minimal language that requires high levels of supervision and support) as they are substantially underrepresented in datasets derived from outpatient or community settings.
Scientists have long known that the Alzheimer's brain often features abnormal plaques and tangles, and recent studies have highlighted the role that the brain's vascular system plays in disease progression. But for decades, this knowledge has failed to translate into fully effective treatments. The lack of progress is largely due to the fact that, despite landmark findings, the precise pathway of neurodegeneration is still unclear.
Food insecurity is a significant burden among U.S. surgical patients, according to a study published online June 18 in JAMA Surgery.
Dietary patterns influence the development of overactive bladder (OAB), according to a study published online May 12 in Frontiers of Nutrition.
Hypertension is the most common chronic condition among adults aged 85 years and older, with the prevalence higher among women than men, according to a report published in the June Health E-Stats.
A popular crisis support line for LGBTQ+ youth and young adults is shutting down July 17, federal officials confirmed this week.