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NSAID-exacerbated respiratory disease is associated with changes in lipid metabolism

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  • 2025-10-07 00:30 event
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NSAID-exacerbated respiratory disease is associated with changes in lipid metabolism
NSAID-exacerbated respiratory disease, N-ERD, is associated with measurable changes in concentrations of lipid mediators involved in inflammation and pain modulation, a new study shows. Plasma concentrations of two key endocannabinoid-related lipids, arachidonoylethanolamide (AEA) and oleoylethanolamide (OEA), were significantly reduced in patients with N-ERD, compared to healthy controls.

11. Zebrafish spine studies reveal new clues to early scoliosis detection

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Dr. Brian Ciruna had no intention of studying scoliosis, a condition that causes unnatural curvature of the spine. However, the unexpected discovery about a decade ago that zebrafish also develop curved spines left him wondering what was causing the spine to bend and whether there was some connection to the human form of the disease. It turns out that this small, minnow-like fish has a lot to tell researchers about a condition that affects 3% to 4% of children and young teens in Canada.

12. New calculator can help physicians better predict stroke risk in atrial fibrillation patients

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Researchers at the UNC School of Medicine and the University of Vermont have developed a more precise way to assess stroke risk in people with atrial fibrillation (A-Fib), a condition that affects 10.5 million Americans and is a leading cause of stroke.

13. 30 years of post-traumatic epilepsy research: Where do we stand?

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For decades, researchers have worked to unravel the mysteries of post-traumatic epilepsy (PTE), a form of epilepsy that emerges after a traumatic brain injury (TBI). Now, a new study led by Texas A&M University neuroscientist Dr. Samba Reddy offers a sweeping view of how far the science has come and how far it needs to go.

14. Link between smoking and high blood pressure confirmed

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Tobacco smoking is associated with an increased risk of hypertension (high blood pressure), a new UM study has found, and testing patients' urine can help to verify their smoking status and assess this risk.

15. Love chewing ice? It could damage your teeth and jaw

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Chewing on ice may seem harmless, perhaps even refreshing, but dental experts warn it can actually wreak havoc on your teeth.

16. Vestibular symptoms stable, improve for most with Meniere undergoing cochlear implant

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Most patients with Meniere disease (MD) who undergo cochlear implantation (CI) in the MD-affected ear have stability or improvement of vestibular symptoms, according to a study published in the September issue of Otology & Neurotology Open.

17. Global health agencies issue new recommendations to help end deaths from postpartum hemorrhage

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Through new guidelines released today in The Lancet Global Health, leading reproductive health agencies are calling for a major shift in how postpartum hemorrhage (PPH) is prevented, diagnosed and treated. The recommendations highlight the urgent need for earlier detection and faster intervention—steps that could save the lives of tens of thousands of women each year.

18. One in four individuals will develop heart failure in their lifetime

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The lifetime risk for heart failure has increased to 24%, according to a report published online Sept. 22 in the Journal of Cardiac Failure.

19. 'Playing to your strengths' improves well-being in adult ADHD, new research shows

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Adults with ADHD who recognize and regularly use their personal strengths report better well-being, improved quality of life and fewer mental health difficulties, according to a new international study.

20. NSAID-exacerbated respiratory disease is associated with changes in lipid metabolism

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NSAID-exacerbated respiratory disease, N-ERD, is associated with measurable changes in concentrations of lipid mediators involved in inflammation and pain modulation, a new study shows. Plasma concentrations of two key endocannabinoid-related lipids, arachidonoylethanolamide (AEA) and oleoylethanolamide (OEA), were significantly reduced in patients with N-ERD, compared to healthy controls.

21. Conflict at the drugstore: When pharmacists' and patients' values collide

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Imagine walking into your pharmacy, handing over your prescription and having it denied. Now imagine that the reason is not insufficient insurance coverage or the wrong dose, but a pharmacist who personally objects to your medication. What right does a pharmacist have to make moral decisions for their patients?

22. How to maintain good cognitive health at any age

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Is it an achievable goal to remain mentally sharp while aging, or is it a pipe dream?

23. From trips to treatments: How psychedelics could revolutionize anti-inflammatory medicine

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Once synonymous with hippies and hallucinatory experiences, psychedelic drugs are now being explored for their medical potential. The stigma of that era resulted in research being suppressed by drug laws, yet with mental health treatments hitting limits, scientists have returned to this controversial corner of medicine.

24. Patient wealth is associated with quality of glaucoma care

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Patients with newly diagnosed glaucoma who have less wealth or reside in rural communities are less likely to receive standard glaucoma care compared to wealthier patients, according to a recent multi-institutional study published in JAMA Ophthalmology.

25. Five-patient lupus CAR T-cell feasibility test claims positive short-term results

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Researchers at the First Affiliated Hospital of the University of Science and Technology of China claim that an in vivo CD8 T-cell-targeted lipid nanoparticle carrying CD19 CAR mRNA (HN2301) generated transient CAR T cells that rapidly depleted B cells and reduced disease activity in five patients with treatment resistant systemic lupus erythematosus.

26. Rare tissue samples reveal where HIV hides in different parts of body

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Researchers at Western and the University of Calgary have discovered how HIV hides in different parts of the body by embedding itself into the DNA of cells in a tissue-specific manner, offering new insights into why the virus is so difficult to eliminate and cure—even decades after infection and treatment.

27. Mental ill-health runs in families, but it doesn't have to

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A new thesis from Karolinska Institutet studied how mental health problems run in families. Using nationwide Swedish registers, the researchers followed millions of parents and their children over decades, revealing several important findings about how and why mental health problems pass from parents to children, and importantly, how to interrupt this cycle.

28. Local ancestry inference method could improve accuracy of genetic testing and patient diagnoses

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Researchers at Texas Children's Neurological Research Institute (NRI) and Baylor College of Medicine have developed a powerful new tool within the Genome Aggregation Database (gnomAD) to sharpen the accuracy of genetic testing—a breakthrough with direct implications for patient diagnoses and care worldwide.

29. Antibody discovered that blocks almost all known HIV variants in neutralization assays

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An international research team led by the University of Cologne has discovered an antibody that could advance the fight against HIV. The newly identified antibody 04_A06 proved to be particularly effective in laboratory tests. It was able to neutralize 98.5% of more than 300 different HIV strains, making it one of the broadest antibodies against HIV identified.

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