New drug formulation turns intravenous treatments into a quick injection

A new study has created the first single-cell map of how DNA is regulated and organized inside different cell-types of human fat tissue. The research shows that many genetic risk factors for abdominal obesity reside in epigenomic regions of fat cells, offering clues about how body fat is genetically and epigenetically regulated and how it might be better controlled. The study, by co-first authors Zeyuan (Johnson) Chen and Sankha Subhra Das, is published in Nature Genetics.

The U.S. Food and Drug Administration (FDA) has approved Novo Nordisk's popular weight-loss drug Wegovy to treat a serious form of fatty liver disease.

A new Northwestern Medicine study has revealed how a common inherited mutation disrupts red blood cell development and sparks inflammation that can lead to leukemia, according to findings published in Nature Communications.

Researchers say the ability to visualize health data in three dimensions can unlock patterns and relationships among predictive biomarkers that conventional data visualization can't convey. That's why Zeeshan Ahmed and his team at Rutgers developed 3D IntelliGenes, an advanced artificial intelligence and machine-learning platform with the ability to visually analyze multiple types of biological and clinical data—known as multiomics.

The robot doctor will see you now? Not for the foreseeable future, anyway.

Findings could lead to earlier detection and treatment for those suffering from the serious eye condition.

Stanford Medicine scientists investigating the neurological underpinnings of autism spectrum disorder have found that hyperactivity in a specific brain region could drive behaviors commonly associated with the disorder.

A new national study led by researchers from Carleton University and the University of Toronto reveals that older adults living in greener neighborhoods were less likely to experience depression during the early months of the COVID-19 pandemic.

Fewer than half of all adolescents with major depressive episode (MDE) received mental health care in the US in 2022, with the odds of specialist treatment being even lower among marginalized groups, according to a study published in the open-access journal PLOS Mental Health by Su Chen Tan and colleagues at University of Tennessee.

Older adults often don't realize how vulnerable they are to extreme heat and most aren't prepared for long periods of hot weather, according to a review of more than 40 studies.

Researchers have developed an AI tool that can help doctors predict who might develop a potentially fatal heart condition, just from an ECG.

An innovative method that uses modified versions of a bacterial virus effective at delivering treatments to human cells shows promise as a more inexpensive and efficient way to treat some deadly genetic diseases.

In adults with severe chronic rhinosinusitis with nasal polyps treated with a daily intranasal corticosteroid, the anti-interleukin 4Rα monoclonal antibody stapokibart improves outcomes, according to a study published online Aug. 18 in the Journal of the American Medical Association.

In endometriosis, cells similar to uterine tissue grow outside the uterus. According to researchers in the Penn State Department of Kinesiology who study the disease, endometriosis is often treated as a purely gynecological condition. In a new study, however, they demonstrated how the condition, which affects 10% of women around the world, alters how the body responds to feedback.

A research team at The Ohio State University Wexner Medical Center and College of Medicine led a study that showed mothers who breastfed their babies, especially those diagnosed with diabetes during pregnancy, have a lower risk of heart issues later in life. The study was recently published in Obstetrics & Gynecology.

A research team involved in the recently published successful transplantation of allogeneic iPS cell-derived dopaminergic neural progenitors into patients with Parkinson's disease, led by former Junior Associate Professor Asuka Morizane and Professor Jun Takahashi (Department of Clinical Application), revealed the clinical safety and immune tolerance of the transplanted cells under moderate immunosuppression, regardless of HLA compatibility.

Two new studies from Karolinska Institutet in Sweden have investigated how mutations that occur in muscles and blood vessels over time can affect aging. The studies, which are published in Nature Aging, show that such mutations can reduce muscle strength and accelerate blood vessel aging. The results can be of significance to the treatment of age-related diseases.

Too much fat can be unhealthy: how fat cells, so-called adipocytes, develop, is crucial for the function of the fat tissue. That is why a team led by researchers from the University Hospital Bonn (UKB) and the University of Bonn investigated the influence of primary cilia dysfunction on adipocyte precursor cells in a mouse model.