New tool using AI for heart failure incorporates views of patients, clinicians, other stakeholders on three continents

An AI algorithm for breast cancer screening has the potential to enhance the performance of digital breast tomosynthesis (DBT), reducing interval cancers by up to one-third, according to a study published today in Radiology.

Renowned physician-scientist Eric J. Topol, M.D., and Harvard artificial intelligence (AI) expert Pranav Rajpurkar, Ph.D., advocate for a clear separation of the roles between AI systems and radiologists in an editorial published in Radiology.

Children who develop deep wrinkles, stunted growth, and rapidly aging bones and blood vessels as early as 1 to 2 years of age may be suffering from Hutchinson-Gilford Progeria Syndrome (HGPS), a rare and incurable genetic disorder that affects approximately one in eight million people. The average life expectancy for patients is just 14.5 years, and to date, no curative treatment exists.

As school returns, parents and teachers might each be faced with the familiar chorus of "I can't find my school jumper" and "I left my hat at home." For parents of older kids, the stakes may be even higher: lost mobile phones or laptops left on the bus.

There are about 70 million baby boomers in the United States, many now over the age of 65. As people age, rates of cardiovascular and cerebrovascular diseases rise, leading to more use of blood thinners such as warfarin. At the same time, older adults face a higher risk of head injuries and brain bleeding, especially after falls.

Scientists studying a hard-to-treat form of blood cancer called acute myeloid leukemia (AML) have found that a type of treatment—immunotherapy—may help change the environment where cancer cells live, possibly helping the immune system respond more effectively.

A multidisciplinary team at UT Southwestern Medical Center has developed an AI-enabled pipeline that can quickly and accurately extract relevant information from complex, free-text medical records. The team's novel approach, published in npj Digital Medicine, could dramatically reduce the time needed to create analysis-ready data for research studies.

U.S. investment in new treatments is often driven by market potential rather than medical necessity, deepening health disparities and costing lives. Researchers say these recommendations could help.

New designer proteins created using an AI tool can selectively target peptide segments that bind to markers on diseased cancer cells, acting like molecular flags that signal immune cells to attack and destroy the threats.

Kidney complications in diabetes often progress silently, putting patients at risk of life-threatening outcomes long before any symptoms appear. Identifying individuals with diabetes who are at risk of rapid kidney function decline or early death has challenged doctors for decades, with traditional markers like serum creatinine and urinary albumin falling short of accurately predicting these risks.

A new study led by researchers at Huntsman Cancer Institute at the University of Utah (the U) shows that regular exercise may do more than help colon cancer patients feel better—it may actually change gene activity in both tumors and surrounding fat tissue.

A multi-institutional team led by the Chinese Academy of Sciences has constructed a proteomic atlas of human aging across 13 organs, revealing tissue-specific aging clocks, transcriptome-proteome decoupling, and secreted proteins that may accelerate systemic decline.

A team headed by Claude Perreault, Director of IRIC's Immunobiology Research Unit and Professor at the Faculty of Medicine at Université de Montréal, has identified novel tumor antigens that could lead to the development of vaccines for the treatment of two cancers: melanoma and non-small cell lung cancer.

Precision medicine promises to tailor health care to the individual. But what happens when entire communities are left out of the data that drives that tailoring?

A Henan University of Science and Technology team reports that boosting miR-542-3p thwarts stress-related cell loss in the hippocampus and eases depressive-like behavior in mice.

An Australian vaping education program being rolled out in schools nationally has been hailed as one of the most successful school-based strategies in the world for curbing youth e-cigarette use in a study published today in The Lancet Public Health.

A review published in Addiction looks at what interventions have been effective in changing the perception of how harmful vaping is, and how that may affect vaping and smoking behaviors.

Scientists in Ghent have achieved a breakthrough in sepsis research. In a study on mice, the researchers demonstrated that vitamin B1 (thiamine pyrophosphate, TPP) restores mitochondrial energy metabolism, drastically reduces lactate production, and increases survival rates in sepsis. The study results are published in Cell Reports.