Human proteome study maps aging signatures across 13 organs

As school returns, parents and teachers might each be faced with the familiar chorus of "I can't find my school jumper" and "I left my hat at home." For parents of older kids, the stakes may be even higher: lost mobile phones or laptops left on the bus.

There are about 70 million baby boomers in the United States, many now over the age of 65. As people age, rates of cardiovascular and cerebrovascular diseases rise, leading to more use of blood thinners such as warfarin. At the same time, older adults face a higher risk of head injuries and brain bleeding, especially after falls.

Scientists studying a hard-to-treat form of blood cancer called acute myeloid leukemia (AML) have found that a type of treatment—immunotherapy—may help change the environment where cancer cells live, possibly helping the immune system respond more effectively.

A multidisciplinary team at UT Southwestern Medical Center has developed an AI-enabled pipeline that can quickly and accurately extract relevant information from complex, free-text medical records. The team's novel approach, published in npj Digital Medicine, could dramatically reduce the time needed to create analysis-ready data for research studies.

U.S. investment in new treatments is often driven by market potential rather than medical necessity, deepening health disparities and costing lives. Researchers say these recommendations could help.

New designer proteins created using an AI tool can selectively target peptide segments that bind to markers on diseased cancer cells, acting like molecular flags that signal immune cells to attack and destroy the threats.

The "Trustworthy Artificial Intelligence for Personalized Risk Assessment" (AI4HF) project has successfully engaged clinicians, patients and other stakeholders across Europe, South America and Africa to achieve its target to co-design, develop and evaluate the first trustworthy artificial intelligence (AI) tool for personalizing the care and management of patients with heart failure.

Kidney complications in diabetes often progress silently, putting patients at risk of life-threatening outcomes long before any symptoms appear. Identifying individuals with diabetes who are at risk of rapid kidney function decline or early death has challenged doctors for decades, with traditional markers like serum creatinine and urinary albumin falling short of accurately predicting these risks.

A new study led by researchers at Huntsman Cancer Institute at the University of Utah (the U) shows that regular exercise may do more than help colon cancer patients feel better—it may actually change gene activity in both tumors and surrounding fat tissue.

A team headed by Claude Perreault, Director of IRIC's Immunobiology Research Unit and Professor at the Faculty of Medicine at Université de Montréal, has identified novel tumor antigens that could lead to the development of vaccines for the treatment of two cancers: melanoma and non-small cell lung cancer.

Precision medicine promises to tailor health care to the individual. But what happens when entire communities are left out of the data that drives that tailoring?

A Henan University of Science and Technology team reports that boosting miR-542-3p thwarts stress-related cell loss in the hippocampus and eases depressive-like behavior in mice.

An Australian vaping education program being rolled out in schools nationally has been hailed as one of the most successful school-based strategies in the world for curbing youth e-cigarette use in a study published today in The Lancet Public Health.

A review published in Addiction looks at what interventions have been effective in changing the perception of how harmful vaping is, and how that may affect vaping and smoking behaviors.

Scientists in Ghent have achieved a breakthrough in sepsis research. In a study on mice, the researchers demonstrated that vitamin B1 (thiamine pyrophosphate, TPP) restores mitochondrial energy metabolism, drastically reduces lactate production, and increases survival rates in sepsis. The study results are published in Cell Reports.

Patients with post-traumatic stress disorder (PTSD) often struggle to forget traumatic memories, even long after the danger has passed. This failure to extinguish fear memories has long puzzled scientists and posed a major hurdle for treatment, especially since current medications targeting serotonin receptors offer limited relief for only a subset of patients.

Eight different vitamins make up the B complex, and they all play crucial roles in the body, such as producing energy, keeping our nervous system healthy, and supporting cell development. If eight sounds like a lot to keep track of, it might help to know that most research focuses on five in particular: thiamine (B1), riboflavin (B2), niacin (B3), folate (B9), and cobalamin (B12).

About 2.7 million people in the U.S. live with inflammatory bowel diseases, which cause long-term inflammation in the digestive system. The number of children diagnosed with these conditions, like Crohn's disease, is rising faster than in adults, but the reasons for the increase are puzzling.