Newly discovered cellular trigger could lead to possible therapies for Parkinson's disease

A wound can leave a lasting imprint—even after it has healed. A new study in Current Biology finds that past injuries can quietly prime the body to overreact and be more sensitive to stress, pain and fear long after the damage is gone.

Suboptimal dialysis initiation, typically defined as dialysis initiation during a hospitalization and/or with a central venous catheter, is common among patients with advanced chronic kidney disease (CKD) followed in multidisciplinary clinics, according to a study published online July 21 in Kidney360.

Ritz peanut butter cracker sandwiches are being recalled due to the possible presence of undeclared peanuts, a major allergen.

Keurig K-Cups are being recalled nationwide due to a packaging issue that could cause ink to run into the coffee during brewing.

Faced with a lack of running water, unsanitary conditions and poverty, the Kinshasa neighborhood of Pakadjuma has struggled to end a cholera epidemic that has claimed hundreds of lives in the Democratic Republic of Congo (DRC) this year.

China is experiencing an outbreak of chikungunya, a mosquito-borne infection, with thousands of cases reported in the south.

Each cell in our bodies carries about two meters of DNA in its nucleus, packed into a tiny volume of just a few hundred cubic micrometers—about a millionth of a milliliter. The cell manages this by winding the strings of DNA around protein spools. The protein-DNA complexes are called nucleosomes, and they ensure that DNA is safely stored.

The origin of some neuropsychiatric diseases, such as autism, bipolar disorder, or depression, and certain neurodegenerative diseases, Alzheimer's and Parkinson's, can be found in very early stages of brain formation in the fetus. That is, earlier than previously recognized, according to a study by the Hospital del Mar Research Institute and Yale University, published in Nature Communications.

The laminin-411 protein is vital for the formation of the myelin membrane by oligodendrocytes, report researchers from Japan. Furthermore, the A4G47 peptide from the E8 region of laminin-411 was found to be the main active amino acid sequence that drives myelin formation. The research findings have the potential to transform current cell culture practices to study myelination and may enable the development of novel therapeutic agents to treat demyelinating diseases.

People who are gestational carriers (or "surrogates") appear more likely to be diagnosed with a new mental illness during and after pregnancy, according to new research from ICES, McGill University, and the Research Institute of the McGill University Health Center.

Using mathematical analysis of patterns of human and animal cell behavior, scientists say they have developed a computer program that mimics the behavior of such cells in any part of the body. Led by investigators at Indiana University, Johns Hopkins Medicine, the University of Maryland School of Medicine and Oregon Health & Science University, the new work was designed to advance ways of testing and predicting biological processes, drug responses and other cell dynamics before undertaking more costly experiments with live cells.

Thanks to vaccinations against SARS-CoV-2 in the period 2020–2024, 2.533 million deaths were prevented at the global level; one death was avoided for every 5,400 doses of vaccine administered.

Researchers from Columbia Engineering have established a framework for the design of bioactive injectable hydrogels formulated with extracellular vesicles (EVs) for tissue engineering and regenerative medicine applications.

The ongoing conflict in the Middle East is having a significant impact on the mental health and well-being of Australian women who migrated from directly impacted countries, or have family ties to the region, according to researchers from UNSW Sydney and The Australian National University (ANU).

In soccer games, "ball-trapping"—quickly changing direction after receiving a pass to transition into an attack—is a critical maneuver. This action can significantly influence the flow of a match, especially when executed effectively in the space between an opponent's midfield and defensive lines. However, the specific physical techniques used by skilled ball-trappers during actual gameplay have not been well understood.

The number of Americans caring for an older or disabled family member has risen dramatically during the past 10 years, according to a new AARP policy report.

A virus that typically infects black-eyed peas is showing great promise as a low-cost, potent cancer immunotherapy—and researchers are uncovering why.

Researchers at the University of Arizona Mel and Enid Zuckerman College of Public Health found that certain kinds of long-lasting chemicals firefighters are exposed to may affect the activity of genes linked to cancer and other diseases. The findings appear in the journal Environmental Research.