Osteoarthritis: Too many non-evidence-based therapies?

Be it peanuts or other triggers, many families live with the day-to-day risk that their child might experience a sudden and scary allergic reaction. Pediatric emergency department visits in the United States to treat acute allergic reactions more than tripled from 2008 to 2016.

It is known that vasculopathy plays a pivotal role in the pathogenesis of systemic sclerosis (SSc). Vasoactive vasodilating drugs (VVD) are an option. The most recent treatment recommendations from EULAR—The European Alliance of Associations for Rheumatology—note that advances in vasculopathy management for patients with SSc emphasize a treatment continuum for the use of various VVD, but also stress the need for trials to look for potential synergistic combinations as well as high-quality real-world data to build the evidence. New data shared at the 2025 EULAR congress in Barcelona may take a step in that direction.

New research from the University of Minnesota Medical School suggests that different genetic forms of autism may lead to similar patterns in brain activity and behavior. The findings were recently published in Nature Neuroscience.

Adolescents and young adults with chronic diseases need special care—and pediatric rheumatological conditions can persist into adulthood. Two new works presented at the 2025 congress of EULAR—The European Alliance of Associations for Rheumatology—consider the training that health care professionals need to help support transition for younger patients, and the perspectives and experiences of young adults.

Alcohol-related liver disease deaths are increasing—and they're rising faster in some groups, including women, young adults and Indigenous people, new research shows.

During the early days of the COVID-19 pandemic, there was a decline in the physical fitness of U.S. youth, according to a study published online June 4 in JAMA Network Open.

A research team at Toho University has revealed that ferulic acid (FA), a polyphenol abundant in rice bran, suppresses intestinal smooth muscle contractions by inhibiting voltage-dependent calcium channels. This finding may open new avenues for dietary-based strategies to manage intestinal motility disorders such as irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD).

About 525,000 more deaths occurred among US adults in 2023 than would be expected had pre-2010 mortality trends continued. More than 90% of these deaths occurred among individuals without a bachelor's degree and were largely caused by cardiovascular diseases, underscoring how educational attainment can influence individuals' health opportunities and outcomes.

Regular physical activity is increasingly promoted for people with rheumatic and musculoskeletal diseases (RMD) as well as the general population. EULAR—The European Alliance of Associations for Rheumatology—has published recommendations for physical activity in people with inflammatory arthritis and osteoarthritis. There are also points to consider on helping people participate in healthy and sustainable paid work.

EULAR—The European Alliance of Associations for Rheumatology—believes that nurses are an important part of the health care team, especially for providing evidence-based care and endorsing shared decision-making in consultation with the patient. This is also important considering the shortage of rheumatologists in Europe, which means delegation is necessary.

When receiving a diagnosis of a rheumatic musculoskeletal disease (RMD), people need a lot of information. Some need it all at once, while others may prefer to receive it in smaller portions or like to spread it out. This can mean that rheumatologists and other health care professionals do not always know how best to support patient education.

Rheumatic musculoskeletal diseases (RMD) have an important impact on quality of life, and represent an economic burden to society. EULAR—The European Alliance of Associations for Rheumatology—has emphasized the role of patient empowerment through education.

Rheumatic and musculoskeletal diseases (RMD) are the leading causes of disability worldwide, resulting in significant health care and social support costs. One of the reasons for this increasing burden seems to be the variability in the number and nature of allocated resources across Europe, as well as organizational aspects of health systems that result in disparities and health inequities across countries.

Diabetic foot ulcers (DFUs) are a major clinical challenge, with high rates of morbidity, disability, amputations and mortality. Despite extensive research, effective predictive biomarkers for DFUs healing remain elusive.

Chimeric antigen receptor (CAR)-T cells are a promising cancer therapy that are made from the patient's own T cells, which are reprogrammed to fight their cancer. One of the limitations of CAR-T cell therapy is the ability of these cells to survive long enough to target the entire tumor.

When a house is hit by a hurricane, you must first remove the damaged parts before reconstruction can begin. The same applies to our muscles after injuries—and now researchers from Aarhus University and Steno Diabetes Center Aarhus have discovered who functions as the coordinator of this repair process.

A novel immuno-PET/CT imaging technique has identified and validated a potent biomarker for nasopharyngeal cancer (NPC). The biomarker, CD70, is highly and constantly expressed in NPCs, and CD70-targeted immuno-PET/CT has proven effective in accurately detecting primary and metastatic NPC lesions.

The adoption of the WHO Pandemic Agreement by the World Health Assembly on 20 May 2025 was a landmark moment in global health.