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Ovarian tumor immune landscapes offer clues to better therapy

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  • 2025-07-31 23:29 event
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Ovarian tumor immune landscapes offer clues to better therapy
The immune system is a major determinant of how patients respond to standard treatments for ovarian cancer, the leading cause of death from gynecological malignancies. But little was known about how the immune landscape of tumors changes when patients relapse—as they frequently do—or how those changes influence responses to subsequent therapy, which tend to be dismal.

858. Rates of sports betting, problem gambling show increase among monthly gamblers in Massachusetts in 2024

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In the latest online gambling surveys conducted by the University of Massachusetts Amherst, monthly gamblers in Massachusetts reported ongoing higher levels of sports betting, gambling intensity and gambling harms, with their attitudes toward gambling continuing to be more negative.

859. Function behind mysterious variants for gene linked to colon cancer identified

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Genes get passed down from parents, determining traits such as eye color and height as well as risk for certain diseases.

860. Hibernator 'superpowers' may lie hidden in human DNA

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Animals that hibernate are incredibly resilient. They can spend months without food or water, muscles refusing to atrophy, body temperature dropping to near freezing as their metabolism and brain activity slow to a crawl. When they emerge from hibernation, they recover from dangerous health changes similar to those seen in type 2 diabetes, Alzheimer's disease, and stroke.

861. Removal of ventilator breathing tube is delayed for some patients, posing health risks

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Research from the University of Michigan Medical School finds that one in three hospitalized patients remain connected to a breathing tube after passing a spontaneous breathing trial.

862. Large-scale gene analysis identifies new biomarkers and drug targets for lung adenocarcinoma

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By analyzing tens of thousands of genes, proteins, and protein modifications in hundreds of lung tumors, an international research team has uncovered new factors linked to poor outcomes in lung adenocarcinoma in both smokers and people who have never smoked. These factors include a pattern of DNA damage and signatures of exposures to chemicals found in processed foods and cosmetics. The findings could lead to better precision medicine strategies for this most common type of lung cancer.

863. Internalizing stress may lead to cognitive decline in older Chinese Americans

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Stress internalization is a significant risk factor for age-related cognitive decline in older Chinese Americans, according to Rutgers Health researchers.

864. FDA vaccine chief steps down after controversial tenure

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The U.S. Food and Drug Administration's (FDA) top vaccine official is stepping down after just three months in a role that upset drug companies, patient groups and some political leaders.

865. AI-generated ads match official campaigns in youth vaping awareness study

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Generative artificial intelligence could take years off the time between identifying public health risks and launching impactful mass media campaigns.

866. Crushed testicles and back pain: Police uniforms in England and Wales 'unfit for purpose,' survey reveals

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Police officers and staff in England and Wales are frustrated with their uniforms, which they say are unfit for purpose, restrictive and contribute to major health issues.

867. Ovarian tumor immune landscapes offer clues to better therapy

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The immune system is a major determinant of how patients respond to standard treatments for ovarian cancer, the leading cause of death from gynecological malignancies. But little was known about how the immune landscape of tumors changes when patients relapse—as they frequently do—or how those changes influence responses to subsequent therapy, which tend to be dismal.

868. FDA panel casting doubt on antidepressant use in pregnancy could lead to devastating outcomes for mothers

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At a meeting held by the Food and Drug Administration on July 21, 2025, a panel convened by the agency cast doubt on the safety of antidepressant medications called selective serotonin reuptake inhibitors, or SSRIs, in pregnancy.

869. Ground beef shipped to 5 states recalled for possible metal pieces

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More than 1,000 pounds of frozen ground beef are being recalled after metal pieces were reportedly found in the product.

870. High Noon recalls vodka seltzer cans mislabeled as energy drinks

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High Noon is recalling some of its vodka seltzer packs after finding that a few cans were incorrectly labeled as non-alcoholic energy drinks.

871. Are you really allergic to penicillin? A pharmacist explains why there's a good chance you're not

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Imagine this: You're at your doctor's office with a sore throat. The nurse asks, "Any allergies?" And without hesitation you reply, "Penicillin." It's something you've said for years—maybe since childhood, maybe because a parent told you so. The nurse nods, makes a note and moves on.

872. System wide program shows improvement for treating opioid use disorder

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Routinely offering and initiating medication-based treatment for those with opioid use disorder has the potential to save lives in health care settings throughout the country, according to the authors of a new study from The Ohio State University.

873. Study suggests radiation therapy benefits misjudged when clinical factors alone guide breast cancer treatment

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A study published in the International Journal of Radiation Oncology*Biology*Physics demonstrates that clinicopathology (CP) based risk assessment frequently fails to accurately assess recurrence risk and radiation therapy benefit for patients diagnosed with DCIS (ductal carcinoma in situ). Consequently, treatment decisions based on CP alone may result in over 40% of women being over- or undertreated with radiation therapy when compared to the molecular-based test DCISionRT.

874. Vasectomy, pain and regret: What online forum Reddit reveals about men's experiences

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Vasectomy has long been regarded as a permanent, safe and effective form of contraception. Its benefits are often summarized as minimally invasive and largely risk-free.

875. Combining MYC inhibitors with metabolic drugs may boost cancer treatment efficacy

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Northwestern Medicine investigators have discovered a new combination approach that may improve the efficacy of MYC inhibitor drugs for treating aggressive and treatment-resistant cancers, according to a recent Northwestern Medicine study published in Science Advances.

876. Quad bike deaths have reduced since Australian safety standards changed in 2019

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New research published today shows there has been a small reduction in quad bike deaths at work in Australia since new safety standards were introduced five years ago, but public health experts say more needs to be done to keep Australians safe at work and on farms.

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