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Overlooked strategy shows promise for treating KRAS-mutated colon cancer

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  • 2025-05-26 23:54 event
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Overlooked strategy shows promise for treating KRAS-mutated colon cancer
KRAS mutations are among the most common genetic alterations in cancer and are considered particularly difficult to treat. In colon cancer, the second most common cause of cancer death, such mutations severely limit therapeutic options.

2.337. Message from Dr Hanan Balkhy WHO Regional Director for the Eastern Mediterranean on the ...

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31 May 2025 Tobacco use is the leading cause of preventable death globally, and a major health challenge in the Eastern Mediterranean Region.  An estimated 37 million children aged 13-1

2.338. Location matters: Belly fat compared to overall body fat more strongly linked to psoriasis risk

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Researchers have found that central body fat, especially around the abdomen, is more strongly linked to psoriasis risk than total body fat, particularly in women. This link between central fat and psoriasis remained consistent regardless of genetic predisposition, indicating that abdominal fat is an independent risk factor.

2.339. Global warming could be driving up women's cancer risk, find researchers

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Scientists have found that global warming in the Middle East and North Africa is making breast, ovarian, uterine, and cervical cancers more common and more deadly. The rise in rates is small but statistically significant, suggesting a notable increase in cancer risk and fatalities over time.

2.340. Panel recommends statins for adults with HIV at risk for cardiovascular disease

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In February 2024, the U.S. Department of Health and Human Services Panel for the Use of Antiretroviral Agents in Adults and Adolescents with HIV (ARV Guidelines Panel), in collaboration with the American College of Cardiology (ACC), the American Heart Association (AHA), and the HIV Medicine Association (HIVMA), developed statin therapy recommendations for people with HIV (PWH).

2.341. Astrocyte protein RTP801 may contribute to cognitive decline in Alzheimer's disease

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A research team at the University of Barcelona's Institute of Neurosciences (UBneuro) has discovered new molecular mechanisms related to the cognitive decline associated with Alzheimer's disease, the most common dementia. This study, carried out on animal models with the disease, describes for the first time the decisive role of the RTP801 protein in cells known as astrocytes during the progression of this neurodegenerative disease.

2.342. Comprehensive action plan calls for education, workplace support and research on menopause

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Hot flashes, memory loss, difficulty concentrating, mood swings, urinary incontinence and joint pain: these are just some of the more than 100 symptoms associated with the menopause, a natural process that all women go through when they stop ovulating and menstruating, typically between the ages of 45 and 55.

2.343. Cutting the diagnosis journey for children born with rare genetic diseases

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In its standard definition, the word "rare" describes something that doesn't happen very often.

2.344. Reevaluating 'seriousness' in genetic conditions

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There are differences of opinion in how to assess "seriousness" in genetic conditions. "In Japan, the seriousness of genetic disorders has traditionally been assessed using narrow medical criteria, limiting access to preimplantation genetic testing for monogenic diseases to only a small number of conditions.

2.345. FDA-approved FGFR inhibitors show promise against rare and aggressive pediatric brain tumor

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A study led by researchers at Dana-Farber/Boston Children's Cancer and Blood Disorders Center and the Broad Institute of MIT and Harvard has uncovered critical insights into the biology of embryonal tumor with multilayered rosettes (ETMR), a rare and aggressive brain tumor affecting young children.

2.346. Overlooked strategy shows promise for treating KRAS-mutated colon cancer

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KRAS mutations are among the most common genetic alterations in cancer and are considered particularly difficult to treat. In colon cancer, the second most common cause of cancer death, such mutations severely limit therapeutic options.

2.347. Freeze branding: The new body modification technique causes serious and irreversible harm

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If you're a fan of the TV show Yellowstone, you'll know the deal—you earn your place on the ranch by being branded. On the show, this means having a red-hot iron pressed into your flesh, leaving a permanent scar of loyalty to Yellowstone Dutton Ranch and its patriarch, John Dutton.

2.348. Hypnosis may help in the management of pain and stress experienced by dental patients

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Hypnosis could play a significant role in at least three areas of dental care: managing acute pain during dental procedures, reducing the anxiety associated with visiting the dentist, and alleviating chronic orofacial pain.

2.349. Brain stimulation combined with cognitive training can curb impulsive eating

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Scientists at the Mind, Brain, and Behavior Research Center at the University of Granada (CIMCYC) have revealed how, when faced with highly appetizing and unhealthy food stimuli, many overweight people or those prone to binge eating keep their impulsive system hyperactive, while their reflective or conscious thinking system takes a back seat.

2.350. Antibodies with an Achilles' heel: How viruses escape the immune defense system

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Monoclonal antibodies against SARS-CoV-2 were considered a promising approach for the prevention and therapy of coronavirus infections. However, the ongoing evolution of the virus regularly produces new variants that are no longer neutralized by the antibodies.

2.351. Spleen-based islet transplantation restores glycemic control in type 1 diabetes without full immunosuppression

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Wenzhou Medical University researchers have reimagined the spleen as a viable site for islet transplantation, enabling long-term diabetes control without the burden of full immunosuppression. Nanoparticle-driven spleen remodeling allowed transplanted mouse, rat, and human islets to restore normal blood sugar in diabetic rodents and cynomolgus macaques.

2.352. Climate change driving sexual and reproductive health risks among young adolescents in Kenya

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Climate change and extreme weather events are threatening the sexual and reproductive health (SRH) of young adolescents in Kenya, according to a new study published earlier this month in BMJ Global Health. The study reveals that food, water, and sanitation insecurities are placing young adolescents aged 10–14, especially girls, at increased risk of school dropout, transactional sex, gender-based violence, and early pregnancy.

2.353. How Trump aims to slash federal support for research, public health and Medicaid

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Health care has proved a vulnerable target for the firehose of cuts and policy changes President Donald Trump ordered in the name of reducing waste and improving efficiency. But most of the impact isn't as tangible as, say, higher egg prices at the grocery store.

2.354. Understanding one gene's role in different neurodevelopmental disorders

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Researchers have identified how variations in a gene called TRIO can influence brain functions and result in distinct neurodevelopmental diseases. The study, published in the journal eLife, could pave the way for future therapeutic developments.

2.355. Trump's team cited safety in limiting COVID shots: Patients, health advocates see more risk

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Larry Saltzman has blood cancer. He's also a retired doctor, so he knows getting COVID-19 could be dangerous for him—his underlying illness puts him at high risk of serious complications and death. To avoid getting sick, he stays away from large gatherings, and he's comforted knowing healthy people who get boosters protect him by reducing his exposure to the virus.

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