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PA-915 molecule shows long-lasting antidepressant effects without common side effects in mice

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  • 2025-09-29 23:40 event
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PA-915 molecule shows long-lasting antidepressant effects without common side effects in mice
Depression and anxiety disorders are among the most widespread mental health disorders, with estimates suggesting that they affect around 264 million and 284 million people worldwide, respectively. Depression is a mood disorder characterized by persistent sadness and a loss of interest in everyday activities, while anxiety disorders are marked by high levels of nervousness, worry and fear, either in specific situations or generalized.

55. Liver fat, not weight, predicts health risks in obese children

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A study conducted at Tel Aviv University and Dana Dwek Children's Hospital in Tel Aviv found that disease can be prevented in children with obesity by maintaining a low percentage of fat in the liver. The researchers used innovative methods to examine 31 Israeli children with obesity, in an attempt to understand why some have developed illnesses as a result of their excess weight—while others remain healthy (so far).

56. Genetic variation linked to chemotherapy-related liver damage in patients with colorectal cancer liver metastases

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A new international study led by Mayo Clinic researchers has identified a genetic factor that may explain why some patients with colorectal cancer that has spread to the liver experience more severe liver damage after chemotherapy.

57. Social prescribing has risen sharply among England's general practitioners

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More than 1 million people a year are now being referred by general practitioners (GPs) to social prescribing services, according to a new study led by researchers at UCL.

58. RNA isoform atlas may improve understanding of cardiovascular disease

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Northwestern Medicine scientists have developed a comprehensive atlas of genetic coding sequences in both healthy adult hearts and those with heart failure, a resource that has the potential to improve the understanding of heart health and inform the development of new therapeutic targets for cardiovascular disease, as detailed in a recent study published in Circulation.

59. Identity distress fuels mental health issues in autism

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A new study from the Department of Psychology at Durham University has found that identity distress (difficulty forming a cohesive identity) could be behind the higher rates of poor mental health experienced by autistic people.

60. Walking shapes how people process sound, study suggests

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Does walking influence how people process sensory information, like sounds, from the environment? In a new JNeurosci paper, researchers led by Liyu Cao, from Zhejiang University, and Barbara Händel, from University of Würzburg, explored whether walking direction influences how people process sounds.

61. Anesthesia team overcomes IV fluid crisis with algorithm

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As we mark the first anniversary of flooding from Hurricane Helene that devastated parts of North Carolina, the anesthesia department at the Medical University of South Carolina is sharing how it responded to one effect of that flooding: the disruption of the IV fluid supply chain.

62. Drug-resistant Salmonella rife in Uganda's poorest region

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In the dry, isolated area of Karamoja in northeastern Uganda—the country's poorest sub-region—children have long suffered from malnutrition and water shortages.

63. Drug candidate blocks lung cancer growth without harming healthy cells

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Lung cancer remains one of the deadliest cancers worldwide, with survival rates stubbornly low despite advances in surgery, chemotherapy, and immunotherapy. But a new discovery may change the way doctors approach treatment.

64. PA-915 molecule shows long-lasting antidepressant effects without common side effects in mice

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Depression and anxiety disorders are among the most widespread mental health disorders, with estimates suggesting that they affect around 264 million and 284 million people worldwide, respectively. Depression is a mood disorder characterized by persistent sadness and a loss of interest in everyday activities, while anxiety disorders are marked by high levels of nervousness, worry and fear, either in specific situations or generalized.

65. Getting more fiber into British diets will take teamwork and guts

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British adults eat just 18g of dietary fiber daily, far below the recommended 30g, putting millions at risk of developing heart disease, type 2 diabetes, and colorectal cancer.

66. How doctors are using AI to improve radiation treatment

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She has helped robots learn to get around indoors and pick up balls from the ground. And she has developed computer programs to monitor traffic at intersections.

67. High pollen count: The last straw effect on suicide risk

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Beyond the sneezing and itchy eyes, high pollen seasons are now linked to a significant increase in suicide risk.

68. Psychedelics alter far more neurons than expected

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The most basic assumption about how psychedelic medicine works is at least partially flawed: Psychedelics are altering not just a few specific brain cells, but the vast majority of them, according to a new University of Michigan study published in Molecular Psychiatry.

69. From pea protein to buckwheat: Surprising foods that can trigger severe allergic reactions

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Food allergies are no longer limited to the usual suspects. Peanuts and shellfish may still dominate the headlines, but a growing number of people are reacting to foods not currently recognized in UK allergen laws.

70. Zika virus may raise long-term risks of type 2 diabetes

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It has been ten years since Brazil faced a major outbreak of the Zika virus. The alert was given in 2015, when the country's north-eastern states reported a sudden increase in the number of babies born with unusually small heads—a condition called microcephaly.

71. Don't cut them out: Lymph nodes may be key to cancer treatment

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Removing lymph nodes during cancer surgery has saved countless lives in many tumor types. Yet recent research is challenging parts of this long-standing practice.

72. Why scientists may be fearful of speaking out about Trump's autism claims

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"Are you making good health decisions?" reads one Robert F. Kennedy Jr. meme on social media, a slogan printed against an image of a smiling US health secretary. Such social media posts invariably invite lively comments beneath them, but the situation is deadly serious.

73. One-hour, low-cost HPV test could transform cervical cancer screening in Africa and beyond

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A team of researchers led by Rice University, in collaboration with colleagues in Mozambique and The University of Texas MD Anderson Cancer Center, has developed a simple, affordable human papillomavirus (HPV) test that delivers results in less than an hour with no specialized laboratory required. The breakthrough could provide an option for women in low-resource settings to be screened and treated for cervical cancer in a single clinic visit, a step that global health experts say could save countless lives. The research was recently published in Nature Communications.

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