Partial match parity: Increasing the donor pool for hematopoietic stem cell transplantation

A systematic review from King's College London sets out to explore the geographic barriers to dental care and makes dental access recommendations for health policy.

Scientists have refined a new way of using genetics to identify whether someone has type 1 or type 2 diabetes in Chinese populations—and it is now being used in a large clinical trial to improve treatment in the region.

What if a blood test could reveal the pace of our aging—and the diseases that may lie ahead? The labs of Profs. Liran Shlush and Amos Tanay at the Weizmann Institute of Science have been conducting in-depth studies into the biology of blood to better understand the aging process and why some people become more susceptible to disease over the years.

A team of researchers from the Keck School of Medicine of USC's Mark and Mary Stevens Neuroimaging and Informatics Institute (Stevens INI) has identified a new brain imaging benchmark that may improve how researchers classify biologically meaningful changes associated with Alzheimer's disease, especially in Hispanic and non-Hispanic white populations.

Hepatitis B virus (HBV) infection is known to be associated with the risk of hepatocellular carcinoma (HCC), but how and why they are connected remains unknown. Researchers from Mass General Brigham discovered that HBV does not cause liver inflammation or cancer on its own, but worsens liver inflammation and may make patients more susceptible to early cancer development caused by environmental carcinogens. Limiting carcinogen exposure or reducing inflammation could mitigate this risk. The results are published in Nature Communications.

As sport-related concussions continue to spark global concern, researchers at the University of South Australia (UniSA) are turning their attention to a largely overlooked group—non-professional athletes—calling for more rigorous return-to-play assessments to protect everyday players.

Fatty liver disease, caused by the accumulation of fat in the liver, is estimated to affect one in four people worldwide. If left untreated, it can lead to serious complications, such as cirrhosis and liver cancer, making it crucial to detect early and initiate treatment.

The U.S. Food and Drug Administration (FDA) has added new warnings to the Pfizer and Moderna COVID-19 vaccines about a rare heart condition that mostly affects young men.

A new study by UCLA researchers shows that removing a modest $45 out-of-pocket fee significantly improved access to digital breast tomosynthesis (3D mammography), an advanced breast cancer screening technology. Researchers found that eliminating the fee increased overall usage by several percentage points and particularly benefited underserved patient populations, including racial and ethnic minorities and non-English speakers. The study appears in the Journal of the American College of Radiology.

A new update, led by researchers at the UNC School of Medicine and the Gillings School of Global Public Health, describes major findings from the past half decade in the realm of psychiatric genomics and next steps for researchers.

Van Andel Institute scientists and collaborators have discovered a potential treatment target that may re-energize dysfunctional or "exhausted" immune cells in their fight against cancer.

A simple saliva test could transform the lives of millions of children and adults worldwide who are on the keto diet to manage their epilepsy, and who currently endure uncomfortable finger prick tests.

A new study from the University of Michigan Rogel Health Cancer Center, published in Science, sheds light on how two distinct classes of mutations in the FOXA1 gene—commonly altered in prostate cancer—drive tumor initiation formation and therapeutic resistance.

Tarang Parekh was getting ready for work at his apartment in Houston, Texas, in 2022, when he heard gunfire. He'd never heard the sound before, except on TV, but instantly recognized it. He ran downstairs and saw a gruesome scene. It wasn't something he ever expected to see where he lived.

Cedars-Sinai investigators have developed an investigational therapy that brought a significant number of patients with moderate to severe Crohn's disease into remission, according to a new study published in The Lancet Gastroenterology & Hepatology. The findings from the international Phase II-A study suggest that a monoclonal antibody targeting a protein called TL1A could offer a new treatment option for patients with the disease.

Researchers at the University Medical Center Göttingen (UMG) have shown how a minimal change in a single ion channel increases the sensitivity of sensory cells in the inner ear. Even soft sounds, such as a whisper, are perceived more clearly, but can cause prolonged overloading, which can ultimately lead to long-term hearing loss. These findings deepen our understanding of how sound information is encoded in the ear. The results have been published in the journal Science Advances.

A new study shows that the stage of normal cell development at which B cells transform into leukemic cells impacts treatment outcomes for pediatric patients with B-cell acute lymphoblastic leukemia (B-ALL).

Depression affects 1–2% of children younger than 13 in the U.S. and can arise as early as age 3, but a specialized therapeutic intervention can help preschool-aged children find relief from this condition—with benefits lasting at least four years, according to a new study led by researchers at Washington University School of Medicine in St. Louis.