Penicillin allergy testing needed to fight antibiotic resistance

Researchers at the Icahn School of Medicine at Mount Sinai and collaborators have identified a previously overlooked protein, Epac1, as a key driver of idiopathic pulmonary fibrosis (IPF), a chronic and progressive lung-scarring disease. Their findings, demonstrated across cell cultures, preclinical models, and samples of human lung tissue, show that blocking Epac1 can slow the progression of the disease.

New research explains how low levels of the electrolyte sodium in the blood can disrupt the timing of the heartbeat in patients taking widely used rhythm-control medications such as flecainide, which is commonly prescribed for atrial fibrillation and other fast or irregular heart rhythms.

The American Heart Association wants people to know that "there's no reason to avoid seed oils and plenty of reasons to eat them," but some media headlines and social media influencers will ask you to believe otherwise.

A population-based cohort study emulating a target trial estimated the effect of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) compared with sodium-glucose cotransporter-2 (SGLT-2) inhibitors on the risk for gastroesophageal reflux disease (GERD) and its complications in patients with type 2 diabetes.

In a new mouse study, researchers have used optical coherence tomography (OCT) to uncover new insights into how the fallopian tube transports preimplantation embryos toward the uterus for pregnancy. These findings help lay the foundation for understanding certain causes of infertility and pregnancy complications in people.

An AI model trained to detect abnormalities on breast MR images accurately depicted tumor locations and outperformed benchmark models when tested in three different groups, according to a study published in Radiology.

Researchers from the Max Planck Institute of Immunobiology and Epigenetics in Freiburg and ETH Zurich have created the first integrated map detailing the metabolic and molecular changes in human blood stem cells as they age, specialize, or turn cancerous. Their innovative research, made possible by highly sensitive low-input techniques, identifies the nutrient choline as a key player in preserving youthful stem cell traits. This work offers profound insights into stem cell health and disease, suggesting promising directions for nutritional and therapeutic interventions to maintain a healthy blood system.

An unusual DNA structure may hold the key to treating one of the deadliest cancers affecting women, which claims more than 200,000 lives globally each year.

A Flinders University study shows that bowel cancer survivors face an elevated risk of developing multiple primary cancers (MPCs)—for prostate, lung, breast and blood cancer.

Genetic changes can signal evidence of disease, but pinpointing which genes and what's changed can be difficult.

Why do violent conflicts between groups persist—even when all sides suffer as a result? Researchers from psychology and medicine at Heinrich Heine University Düsseldorf (HHU) have now examined the dual effect of physiological stress messengers on social behavior in intergroup conflicts.

A research team at RCSI University of Medicine and Health Sciences has developed a 3D printed implant to deliver electrical stimulation to injured areas of the spinal cord, offering a potential new route to repair nerve damage. Details of the 3D-printed implant and how it performs in lab experiments have been published in the journal Advanced Science.

Thousands of women who undergo radiotherapy for low-risk breast cancer could be spared some of the side effects of treatment after a study confirmed that more targeted treatments are just as effective at controlling the disease in the long term.

The United States could safely drop tetanus and diphtheria booster shots for adults and save an estimated $1 billion a year, according to a new review led by researchers at Oregon Health & Science University.

A collaboration between Vanderbilt University and Washington University researchers produced a population-based cohort study suggesting first-trimester treatment of urinary tract infection (UTI) with trimethoprim-sulfamethoxazole (TMP-SMX) is associated with a higher risk of congenital malformations compared with β-lactam antibiotics, whereas nitrofurantoin and fluoroquinolones show no clear elevated risk.

Although the respiratory system is one of the main entry points for microplastics and nanoplastics (MNPs) from the air into the body, little is known about the effects of these tiny particles on the lungs. Researchers at MedUni Vienna have now demonstrated for the first time that MNPs can trigger malignant changes in lung cells that are associated with the development of cancer. The findings are published in the Journal of Hazardous Materials and once again underline the urgent need for action to reduce plastic waste.

A cancer diagnosis is a life-changing event for patients that can cause short- and long-term mental health concerns as they shift to living within a new timeline driven by weeks or months between medical follow-up appointments.

Every year in the U.S., about 4,000 people die by drowning. Children, men and nonwhite people are at the highest risk.