Positive results revealed from first prospective trial in heart failure due to Chagas disease

Stricken with cancer in infancy, Jessica Lopez endured tumor-fighting treatments that saved her young life but also left her with lasting heart damage.

Exercise decreases the risk of developing cancer. Studies have shown there is a 30–35% reduction in the risk of breast cancer among the most physically active women compared with those who are least active. Exercise also plays a protective role in many other cancers, including lung, endometrial, colon, kidney, bladder and esophageal.

Decision-making, the process through which humans choose between different available options, has been the topic of countless neuroscience, psychology and behavioral science studies. This process does not only include the moment in which a person comes to a decision, but also the evaluation of different options and, at times, changing one's mind.

More than one in every 100 deaths globally is due to suicide, the World Health Organization said Tuesday, calling for urgent action to stem a mounting mental health crisis among young people especially.

Past a smoldering pile of trash and two bleating goats, through a doorway beginning to buckle beneath the weight of the bricks above, is a darkened room where a skeletal, 70-year-old man lies on a pillowless bed above a floor littered with trash.

In the night, when all that glows on this hilltop is the moonlight and all that moves are branches tickled by a soft breeze, the tumult returns. The old woman grows convinced her house is on fire and, panicked, drags the table, chairs and the rest of her few worldly possessions, outside. Unable to calm his mother, her son knows just one way to end it.

A first-of-its-kind clinical trial has shown it's possible to identify breast cancer survivors who are at higher risk of their cancer coming back due to the presence of dormant cancer cells and to effectively treat these cells with repurposed, existing drugs. The research, led by scientists from the Abramson Cancer Center of the University of Pennsylvania and Penn's Perelman School of Medicine, is published in Nature Medicine.

Researchers have identified a neurochemical signature that sets Parkinson's disease apart from essential tremor—two of the most common movement disorders, but each linked to distinct changes in the brain.

Researchers from the University of Birmingham, U.K., have identified bioactive peptide sequences in the PEPITEM molecule, and demonstrated the biological activity of the full PEPITEM molecule in counteracting key changes caused by osteoporosis.

As the UK and other NATO nations dramatically increase defense spending to counter growing global aggressions, one under-recognized aspect of security debates is the role of the arms industry.

Researchers at the University of Southampton examining worldwide variations in funding for cancer research say there's a pressing need to invest more in lower income countries.

Compared with crushed ticagrelor, intravenous cangrelor provided immediate, effective platelet inhibition, with no increase in major bleeding and lower mortality rates in patients with acute myocardial infarction and cardiogenic shock, according to late-breaking research presented in a Hot Line session at the ESC Congress 2025.

A randomized controlled trial aimed to determine whether providing information on patient risk for advanced colorectal neoplasia (ACN) to patients and providers affects colorectal cancer (CRC) screening uptake.

Routine Helicobacter pylori screening did not significantly reduce the risk of upper gastrointestinal bleeding in patients hospitalized for myocardial infarction (MI), according to late-breaking research presented in a Hot Line session at the ESC Congress 2025 and simultaneously published in JAMA.

A Win Ratio analysis confirmed the primary result of the NOAH—AFNET 6 trial and did not find an advantage of anticoagulation with edoxaban over no anticoagulation in patients with device-detected atrial fibrillation. Clinical decisions should therefore be guided by individual factors. The findings were presented by Dr. Nina Becher, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany, in a hotline session at the annual congress of the European Society of Cardiology (ESC) in Madrid.

An analysis of patient-operated ECGs from the EAST—AFNET 4 trial revealed: A low AF burden below 6% in the first year of early rhythm control therapy was associated with low cardiovascular event rates during the subsequent 4 years of follow-up. Patients with a higher AF burden on early rhythm control suffered more AF-related events. The findings were presented by AFNET board member Prof. Ulrich Schotten, Maastricht University, in a hotline session at the annual congress of the European Society of Cardiology (ESC) in Madrid.

Cervical cancer remains one of the most common malignancies in women, ranking as the fourth most prevalent cancer worldwide. Most cases are caused by high-risk strains of human papillomavirus (HPV), particularly HPV16 and HPV18.

Olezarsen decreased levels of triglycerides compared with placebo in patients with moderate hypertriglyceridemia and elevated cardiovascular risk, according to a late-breaking trial presented in a Hot Line session at the ESC Congress 2025 and simultaneously published in the American Heart Journal.