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Scientists reprogram stem cells to create renewable cancer-fighting T cells

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  • 2025-08-01 20:40 event
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Scientists reprogram stem cells to create renewable cancer-fighting T cells
In a first-of-its-kind clinical trial, UCLA scientists have shown it's possible to reprogram a patient's blood-forming stem cells to generate a continuous supply of functional T cells, the immune system's most powerful cancer-killing agents. This approach suggests a new way to deliver immunotherapy, acting as an internal factory that produces tumor-targeting immune cells over time and potentially offering longer-lasting protection.

781. X-ray and radar technology combined to reduce cancer screening risks

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Less radiation exposure during diagnosis and treatment for breast and lung cancer: new Fraunhofer method combines X-ray imaging and radar.

782. Novel radioimmunotherapy eradicates cancer stem cells in ovarian cancer model

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A new radioimmunotherapy approach has been shown to successfully eliminate cancer stem cells (CSCs) in preclinical models of ovarian cancer, outperforming the current gold standard. This research, published in the July issue of The Journal of Nuclear Medicine, lays the foundation for further development of radionuclide therapies targeting CSCs, offering renewed hope for more effective treatment options and improved outcomes for patients.

783. The hidden mental health cost of climate distress

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A new Stanford-led study sheds light on "an emerging psychological health crisis" that disproportionately affects girls. Published July 30 in The Lancet Planetary Health, the study is among the first to quantify how repeated climate stressors impact the psychological well-being and future outlook of adolescents in low-resource settings.

784. Bacteria in the digestive system may work to maintain balance both directly and indirectly

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Intestinal bacteria are important for human health as they help digest food and regulate immune function. Thus, in recent years, it has become clear that gut microbiota dysbiosis, an imbalance in types and composition of intestinal bacteria, is associated with digestive disorders and other diseases. However, the mechanism by which bacteria interact in the intestine to maintain the microbiota balance remains unclear.

785. Researchers identify protein patterns linked to chemotherapy resistance in bladder cancer

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About one quarter of patients with muscle-invasive bladder cancer (MIBC) may be treated and derive a benefit with the current standard chemotherapy. To better understand why some tumors resist chemotherapy and identify better ways to treat those cancers, researchers at Baylor College of Medicine have conducted a detailed molecular analysis of MIBC tumors. The results, published in Cell Reports Medicine, offer potential new ways to identify which patients will benefit from chemotherapy and reveal possible new treatment strategies.

786. Season of birth shows slight association with depression in men but not women

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Males born in summer months reported higher depression symptom scores than males born during other seasons, according to a study from Kwantlen Polytechnic University. Anxiety symptoms showed no association with season of birth for either sex.

787. Wood fires, warm drinks, hot water bottles: 5 expert tips on how to avoid burns this winter

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It's a cold, crisp evening and the air carries a chill that bites. As temperatures drop and houses get colder, we turn to trusted sources of warmth such as wood fires, heaters, hot water bottles and warm drinks.

788. How can I tell if I am lonely? What are some of the signs?

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Without even realizing it, your world sometimes gradually gets smaller: less walking, fewer days in the office, canceling on friends. Watching plans disintegrate on the chat as friends struggle to settle on a date or place for a catch-up.

789. Novel mRNA-based therapy shows promise in heart regeneration after heart attack

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Heart attacks remain a leading cause of death and disability worldwide. The permanent loss of heart muscle cells—known as cardiomyocytes—and the heart's limited regenerative capacity often lead to chronic heart failure. Current treatment strategies manage symptoms but do not repair the underlying damage.

790. Scientists reprogram stem cells to create renewable cancer-fighting T cells

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In a first-of-its-kind clinical trial, UCLA scientists have shown it's possible to reprogram a patient's blood-forming stem cells to generate a continuous supply of functional T cells, the immune system's most powerful cancer-killing agents. This approach suggests a new way to deliver immunotherapy, acting as an internal factory that produces tumor-targeting immune cells over time and potentially offering longer-lasting protection.

791. First person in US treated with novel radiopharmaceutical therapy for breast cancer

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Mayo Clinic has treated the first person in the U.S. using a novel radioactive medicine for advanced breast cancer as part of an international multisite clinical trial.

792. Light-sensitive molecule boosts deep tissue imaging and cell control in mice

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Biomedical and genetic engineers at Duke University and the Albert Einstein College of Medicine have developed a technique that naturally increases the presence of a light-sensitive molecule throughout the body. This change makes it possible to both improve deep tissue imaging in areas like the brain and expand the capabilities of light-based tools to control cellular behavior.

793. Potential chemo-induced cognitive changes discovered in cancer survivors

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Researchers at The City College of New York have linked chemotherapy treatment to lasting cognitive changes in rats—potentially shedding light, for the first time, on cognitive problems some cancer survivors experience long after treatment ends.

794. AI model enhances diagnosis accuracy of high-risk thyroid nodules

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A research team led by Prof. Li Hai from the Hefei Institutes of Physical Science of the Chinese Academy of Sciences has developed a multimodal deep-learning model for predicting the malignancy of TI-RADS 4 thyroid nodules with high-risk characteristics. Their study is published in Computerized Medical Imaging and Graphics.

795. Ushering in a new era of suture-free tissue reconstruction for better healing

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When surgeons repair tissues, they're currently limited to mechanical solutions such as sutures and staples, which can cause their own damage, or meshes and glues that may not adequately bond with tissues and can be rejected by the body.

796. Dual studies reveal early successes for mRNA HIV vaccine strategies

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HIV vaccine efforts have been slowed by the difficulty of getting neutralizing antibodies to target the correct locations of the diverse variants of HIV. Neutralizing antibodies are proteins produced by the immune system that bind to and block the activity of viruses, bacteria, or other pathogens.

797. 'Lifesaving' ketamine offers new hope for PTSD sufferers

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A growing number of Americans are turning to ketamine—long used as a surgical anesthetic and known for recreational misuse—as a powerful treatment for depression and post-traumatic stress disorder, or PTSD. A new University of Florida study, led by 2024 graduate Shahar Almog, Ph.D., suggests that the drug may offer even more mental health benefits than previously thought.

798. RFK Jr. is elevating vaccine hesitancy: Texas advocates were prepared to seize the moment

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Federal health authorities, headed now by U.S. Health Secretary Robert F. Kennedy Jr., are embracing vaccine hesitancy in a way they never have before.

799. The human touch of doctors will still be needed in the AI health care revolution, technology expert suggests

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AI-based medicine will revolutionize care, including for Alzheimer's and diabetes, predicts a technology expert, but it must be accessible to all patients.

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