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Serotonin receptor signaling insights may pave way for next-gen mental health drugs

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  • 2025-08-02 01:00 event
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Serotonin receptor signaling insights may pave way for next-gen mental health drugs
In a discovery that could guide the development of next-generation antidepressants and antipsychotic medications, researchers at the Icahn School of Medicine at Mount Sinai have developed new insights into how a critical brain receptor works at the molecular level and why that matters for mental health treatments.

763. Study finds living in rural environments in first 5 years of life could be a risk factor for developing type 1 diabetes

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New research to be presented at this year's Annual Meeting of the European Association for the Study of Diabetes (EASD) in Vienna, Austria (15–19 September) suggests that living in a rural environment in the first five years of life could increase the risk of developing type 1 diabetes compared with living in urban environments.

764. Study finds rising cannabis use among Black and Hispanic men with chronic illness

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Cannabis use is gaining popularity in the United States, driven by growing legalization, public acceptance and diverse methods of consumption.

765. The power of play in early childhood

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Play is how young children make sense of the world. Whether with dolls, blocks, trains, or playdough, children use play to explore, experiment, and learn. In early childhood, it is essential that children have at least an hour of open-ended play each day, as recommended by research. During this time, they should be encouraged to ask questions, test ideas and engage in creative thinking. Play is not just fun — it is foundational. Play supports cognitive growth, language and communication skills, social and emotional development, physical coordination, creativity, and overall school readiness.

766. Scientists identify shared biological roots of long COVID and chronic fatigue syndrome

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In recent years, doctors and scientists are increasingly studying long-lasting illnesses that begin after someone recovers from an infection. Two of the most well-known examples are long COVID and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).

767. 'And' vs. 'Then': What words in online reviews tell us about hospital visits

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Can simple words like "and" or "then" in online reviews help health care providers learn about their patients' experiences?

768. Medicare could save $3.6 billion without risk to older adults, study suggests

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The federal government's Medicare program and older adults together spend $4.4 billion a year on care that has low clinical value for patients and can even raise their risk of harm, a new study finds.

769. Study identifies three inflammatory pathways behind asthma attacks in children

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A recent multicenter clinical trial has uncovered inflammatory pathways that contribute to asthma flare-ups in children that occur despite treatment, according to findings published in JAMA Pediatrics.

770. Pfizer and BioNTech lose UK court appeal over COVID jab

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US pharmaceutical giant Pfizer and German firm BioNTech lost Friday a court appeal in the latest step of a multi-million pound battle against US rival Moderna over the COVID-19 vaccine.

771. An Ohio couple welcomes a baby boy from a nearly 31-year-old frozen embryo

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A baby boy born last week to an Ohio couple developed from an embryo that had been frozen for more than 30 years in what is believed to be the longest storage time before a birth.

772. Serotonin receptor signaling insights may pave way for next-gen mental health drugs

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In a discovery that could guide the development of next-generation antidepressants and antipsychotic medications, researchers at the Icahn School of Medicine at Mount Sinai have developed new insights into how a critical brain receptor works at the molecular level and why that matters for mental health treatments.

773. Melanoma 'cellular compass' discovery could help curb metastasis

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Researchers have discovered a protein which is critical for steering melanoma cancer cells as they spread throughout the body. The malignant cells become dependent on this protein to migrate, pointing to new strategies for impeding metastasis.

774. When immune commanders misfire: New insights into rheumatoid arthritis inflammation

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Rheumatoid arthritis (RA) is a chronic autoimmune disease in which the immune system mistakenly attacks the lining of the joints (the synovium), causing pain, swelling, and progressive damage. Approximately 18 million people worldwide live with RA. Early diagnosis and treatment can relieve symptoms, slow disease progression, and help prevent disability.

775. Rituximab not superior to conventional strategy for eosinophilic granulomatosis with polyangiitis

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For patients with eosinophilic granulomatosis with polyangiitis (EGPA), rituximab is not superior to the conventional remission induction strategy, according to a study published online July 29 in the Annals of Internal Medicine.

776. Depression in diabetes: Chronic inflammation biomarkers can influence treatment success

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People with diabetes suffer from depression more frequently than average. Researchers from the German Diabetes Center (DDZ), the Research Institute of the Diabetes Academy Mergentheim (Forschungsinstitut an der Diabetes Akademie Mergentheim, FIDAM) and the German Center for Diabetes Research (DZD) were able to show in a large-scale analysis that biomarkers for chronic inflammation levels influence the therapeutic success of depressive symptoms—however, with considerable differences in type 1 and type 2 diabetes. The findings could help to customize the treatment of depression in people with diabetes in the future.

777. New health record system aims to make sharing info easier, but privacy concerns remain

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President Donald Trump has introduced a new effort to help Americans more easily share their health records with doctors, using new technology and artificial intelligence (AI) tools.

778. Multiple sclerosis may begin far earlier than previously thought

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The earliest warning signs of multiple sclerosis (MS) may emerge more than a decade before the first classical neurological symptoms occur, according to new research from the University of British Columbia.

779. Researchers harness AI-powered protein design to enhance T-cell based immunotherapies

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A paper published in Cell highlights how researchers have leveraged AI-based computational protein design to create a novel synthetic ligand that activates the Notch signaling pathway, a key driver in T-cell development and function.

780. Narrower Medicare drug coverage linked to higher relapse rates in MS patients

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Medicare drug plans are increasingly excluding coverage of new specialty drugs that treat complex conditions like cancers and autoimmune diseases. New research from the USC Schaeffer Center shows how these barriers may come at a cost to patients' health.

781. Chikungunya cases surge sixfold in South China city in a week

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A sudden surge of chikungunya cases has been reported in Foshan city in China, increasing from 478 cases to almost 3,000 cases within a week, according to South China Morning Post.

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