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Study finds overtraining syndrome tied to increased PARP1 protein in muscles

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  • 2025-07-03 02:20 event
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Study finds overtraining syndrome tied to increased PARP1 protein in muscles
Excessive physical exercise, especially without adequate rest, can damage the human body in various ways. In severe cases, it can progress to overtraining syndrome, which is characterized by decreased performance and appetite, chronic fatigue, muscle pain, increased injuries, and changes in the immune system and metabolism.

1.679. Unlocking the mystery behind Barrett's esophagus

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A team led by researchers at Baylor College of Medicine and Washington University School of Medicine has shed light on the process that drives Barrett's esophagus formation. This condition affects the lining of the esophagus—the tube that carries food from the mouth to the stomach—and increases the risk of developing esophageal adenocarcinoma, a serious and often deadly cancer.

1.680. Antibody-cancer drug combo shows promise against aggressive lymphoma

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Cancer-hunting antibodies coupled with a natural compound found in soil microbes proved a powerful combination against an aggressive type of blood cancer, according to a new study from scientists at The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology.

1.681. Men with hidradenitis suppurativa perceive better physician communication

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Male patients with hidradenitis suppurativa (HS) perceive better physician communication with respect to demonstrating respect, listening, and explanations, according to a study published online June 19 in The Journal of Dermatology.

1.682. Considerable proportion of colonoscopy bowel preparation claims involve cost-sharing

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A considerable proportion of bowel preparation claims for screening colonoscopy involve patient cost-sharing, according to a research letter published online June 20 in Gastroenterology.

1.683. Obesity linked to financial hardship, food insecurity

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Obesity is associated with financial hardship and food insecurity, according to a research letter published online June 24 in the Annals of Internal Medicine.

1.684. Ancient DNA shows genetic link between Egypt and Mesopotamia

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Ancient DNA has revealed a genetic link between the cultures of ancient Egypt and Mesopotamia, according to research published Wednesday in the journal Nature.

1.685. Sensory-motor activity protocol increases reading speed of children with dyslexia

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After following a protocol of sensory-motor activities with cognitive engagement for two months, eleven children aged 10 to 12 who were diagnosed with dyslexia showed improvement in reading speed. This initiative combined recreational activities that incorporated motor and social skills, demonstrating promise in improving children's reading performance.

1.686. Preventive heart screenings plunged for disabled adults in pandemic years

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A new national study led by researchers at the University of Delaware and George Mason University highlights significant disparities in health care access for adults with disabilities during the COVID-19 pandemic, particularly for preventive cardiovascular screenings.

1.687. AI model converts hospital records into text for better emergency care decisions

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UCLA researchers have developed an AI system that turns fragmented electronic health records (EHR) normally in tables into readable narratives, allowing artificial intelligence to make sense of complex patient histories and use these narratives to perform clinical decision support with high accuracy. The Multimodal Embedding Model for EHR (MEME) transforms tabular health data into "pseudonotes" that mirror clinical documentation, allowing AI models designed for text to analyze patient information more effectively.

1.688. Study finds overtraining syndrome tied to increased PARP1 protein in muscles

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Excessive physical exercise, especially without adequate rest, can damage the human body in various ways. In severe cases, it can progress to overtraining syndrome, which is characterized by decreased performance and appetite, chronic fatigue, muscle pain, increased injuries, and changes in the immune system and metabolism.

1.689. New cell signaling pathway found to shield blood vessels from hypertension damage

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By creating artificial aging in mice, researchers at Lund University in Sweden have been able to track the formation of aneurysms in the walls of blood vessels.

1.690. Theater can improves emotional symptoms of people with Parkinson's

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A research team at the Universitat Oberta de Catalunya, working with the Hospital Sant Pau in Barcelona, has shown that theater can improve the emotional well‐being of people with Parkinson's disease. The study, "Efficacy of a theatre‐based intervention in patients with Parkinson's disease," which has been published in the journal Arts & Health, has provided the first evaluation of the combined effects of active and passive participation in theater activities on these patients' emotional and cognitive health and quality of life.

1.691. Survey finds some confusion over mammogram guidelines

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Mammograms can find cancer early before symptoms appear. Regular screening decreases the risk of dying from breast cancer. But a recent survey question by the Annenberg Public Policy Center shows that some Americans appear to be confused about when women with an average risk of breast cancer should begin a regimen of regular mammograms.

1.692. Preclinical study unlocks a mystery of rapid mouth healing

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Bite the inside of your cheek, and the wound may vanish without a trace in a couple of days. A preclinical study co-led by Cedars-Sinai, Stanford Medicine and the University of California, San Francisco (UCSF), has discovered one secret of this disappearing act. The findings, if confirmed in humans, could one day lead to treatments that enable rapid, scarless recovery from skin wounds on other parts of the body.

1.693. Royalty-based investment model could bridge 'valley of death' between drug discovery and delivery

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A team of researchers from the MIT Sloan School of Management, the Sean M. Healey & AMG Center for ALS at Massachusetts General Hospital (MGH), Questrom School of Business at Boston University, and QLS Advisors have introduced a new approach to funding clinical trials for amyotrophic lateral sclerosis (ALS) therapies.

1.694. Engineered cell cross-talk unlocks CAR-T potential against glioblastoma

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A team of researchers from the San Raffaele-Telethon Institute for Gene Therapy (SR-TIGET, Milan), led by Nadia Coltella and Luigi Naldini, has unveiled a powerful strategy to rejuvenate the effectiveness of chimeric antigen receptor (CAR) T cell therapy against glioblastoma, one of the most lethal and treatment-resistant brain tumors.

1.695. Using viral load tests to help predict mpox severity when skin lesions first appear

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In August 2024, the World Health Organization declared a second "Public Health Emergency of International Concern" for mpox. The current outbreak in Africa is driven mainly by the clade I variant, with multiple countries reporting their first-ever mpox cases of this more severe strain.

1.696. When people express love, they feel more loved

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Expressing love may lead to increased feelings of being loved, which can have downstream effects on people's senses of fulfillment and well-being. Researcher Zita Oravecz and colleagues from Pennsylvania State University, U.S., present these findings in a study published in PLOS One from a survey tracking feelings and acts of love over time.

1.697. Visualizing what happens in inflamed joints of children with arthritis could lead to possible new disease targets

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A new study by researchers from the University of Birmingham, UCL, Great Ormond Street Hospital and Birmingham Children's Hospital has revealed important clues into what is driving disease in children with arthritis.

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