UK health service rejects costly, 'low benefit' Alzheimer's drugs

In a follow-up investigation into the multibillion-dollar drug ticagrelor, The BMJ has uncovered fresh concerns, this time in key platelet studies used in its FDA approval.

Using a newly discovered byproduct of dying cancer cells, University of Wisconsin–Madison researchers are developing personalized vaccines that could help keep aggressive tumors from recurring.

Altum Sequencing, a start-up supported by the C3N-IA Science Park at Universidad Carlos III de Madrid (UC3M) and specialized in oncology, has developed a tool to monitor treatment response in patients with solid tumors from a simple blood sample. This advance could represent a turning point in post-treatment follow-up.

According to a recent study conducted at the University of Jyväskylä, Finland, body composition is associated with symptoms of pelvic floor disorders in middle-aged women. Larger fat mass increases the risk of stress urinary incontinence. The risk factors include larger fat mass, especially in the waist area and around visceral organs, as well as larger waist circumference and body mass index.

In searching for a possible therapeutic target to stop the progress of this disease, an international scientific team, led by researchers at the Department of Cell Biology, Genetics and Physiology of the UMA and also members of the Baglietto lab and the NeuroAD research group, has identified different factors involved in the propagation processes.

Exposure to alcohol during the first weeks of embryonic development changes gene activity and cellular metabolism. In laboratory cultures, it was found that the first cells of the nervous system are the most sensitive to alcohol. This supports the recommendation to abstain from alcohol already when planning a pregnancy.

Before 1846, surgery was a crude and brutal undertaking, typically performed on conscious patients lashed to their beds. Then a Boston dentist publicly demonstrated that the highly flammable chemical diethyl ether—commonly called ether—could render a patient unconscious and insensitive to pain. Overnight, surgery became a major player in modern medicine.

Imagine a condition affecting nearly one-third of the global population, often silently progressing, and deeply intertwined with prevalent health issues like obesity and type 2 diabetes. This is metabolic dysfunction-associated steatotic liver disease, or MASLD, previously known as non-alcoholic fatty liver disease (NAFLD). It's characterized by an excessive accumulation of fat in the liver, which can lead to more severe liver pathologies, including inflammation, fibrosis, and even liver cancer.

A cancer patient in Angola was recovering Thursday after undergoing the first robotic surgery on the continent conducted remotely by a surgeon in the United States, according to the hospitals involved.

A new study of more than 13 million people in England has found no evidence to suggest mild COVID-19 infection may cause long-term kidney damage. However, patients hospitalized with severe COVID-19 infections are at a high risk of long-term kidney damage, the analysis suggests.

Some cancers and chronic inflammatory diseases are treated with immunotherapies. These stimulate the patient's immune system to recognize and destroy tumor cells. To improve such therapies, researchers are looking for mechanisms involved in triggering an immune response.

Whether you are solving a puzzle, navigating a shopping center or writing an email, how well you do will not only depend on the task at hand but also on your internal cognitive state. In a new study published in Nature Communications, researchers at the Ernst Strüngmann Institute in Frankfurt have now shown that such cognitive states can be identified from facial expressions—and can even be used to accurately predict how quickly and successfully a task will be solved.

While many people pride themselves on never forgetting a face, it's just not so easy for others.

A novel study aimed at disentangling the neurological underpinnings of depression shows that multiple brain profiles may manifest as the same clinical symptoms, providing evidence to support the presence of both one-to-one and many-to-one heterogeneity in depression. The findings of the study in Biological Psychiatry, highlight the layered and complex interactions between clinical symptoms and neurobiological sources of variation.

Common viral respiratory infections such as COVID-19, respiratory syncytial virus (RSV) and influenza are linked to an increased short-term risk of stroke and heart attack in adults, new University of Melbourne research has found.

Researchers from Children's Hospital of Philadelphia (CHOP) have identified a novel gene associated with neurodevelopmental disorders and epilepsy. The study, published in the American Journal of Human Genetics, leveraged large data depositories, state-of-the-art computational techniques and community-based gene matching to identify this new gene, which is a critical early step in improving diagnosis and eventually developing new treatment methods.

Radioactive iodine treatment after thyroid cancer surgery usually means side effects like nausea and time in hospital isolated from loved ones. But new clinical trial results from researchers at UCL mean patients worldwide could now safely be spared this treatment.

"Biological stochasticity"—random events at the molecular and cellular level—might be one of the biggest, most overlooked drivers of differences in how we age, says Ryo Sanabria.