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Unlocking the immune system: Cellular 'toolkit' could reprogram cells for cancer therapy

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  • 2025-08-30 00:59 event
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Unlocking the immune system: Cellular 'toolkit' could reprogram cells for cancer therapy
An international team led by researchers at Lund University in Sweden has identified the molecular tools needed to reprogram ordinary cells into specialized immune cells. The discovery, published in Immunity, could pave the way for more precise and personalized cancer immunotherapies.

1.310. After a heart attack, women shown to have worse prognosis when treated with beta-blockers

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A major new analysis from the REBOOT (Treatment with Beta-blockers after Myocardial Infarction without Reduced Ejection Fraction) clinical trial, an international study coordinated by the Centro Nacional de Investigaciones Cardiovasculares (CNIC), published in the European Heart Journal has revealed important sex-specific differences in the effects of beta-blockers following heart attacks, raising questions about long-standing treatment practices.

1.311. Sex-selective abortion bans harm maternal and infant health, according to study

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Sex-selective abortion bans (SSABs)—which prohibit the seeking of abortions based on the fetus' sex—increase the likelihood of low birth weight and preterm births among infants born to Asian immigrant mothers, according to a new study by Yale sociologist Emma Zang.

1.312. Scientists create realistic brain-wide connection maps through digital modeling

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EPFL researchers have developed a powerful method to generate brain-wide, biologically realistic wiring maps of the mouse brain. Their approach bridges experimental data with mathematical and computational modeling to simulate how neurons connect across the entire brain.

1.313. Millions of women rely on contraceptives, but a new study shows they may do more than just prevent pregnancy

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Hormonal birth control is a fact of life for millions of women. In the U.S. alone, more than 60 million women of reproductive age have used contraceptives according to the Centers for Disease Control and Prevention, most often to prevent pregnancy but also to manage conditions such as endometriosis, polycystic ovary syndrome and irregular cycles.

1.314. AI models can help predict in-hospital mortality in ICU patients with lymphoma

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Machine learning (ML) models predict in-hospital mortality in intensive care unit (ICU) patients with lymphoma, according to a study published online Aug. 20 in PLOS ONE.

1.315. Scientists solve medical mystery behind rare multi-organ disease, opening door to new treatments

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A team of scientists led by Duke-NUS Medical School has solved a mystery behind a rare and previously undiagnosed disease that affects multiple organs, shedding new light on its cause—and offering fresh hope for treatment.

1.316. Leukemia stem cell-based method aids relapse prediction in acute myeloid leukemia

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An assay that uses leukemia stem cells (LSCs) to assess measurable residual disease (MRD) outperforms traditional methods in patients with acute myeloid leukemia (AML), according to a study published online Aug. 23 in Bone Marrow Transplantation.

1.317. Clinical trial shows constipation drug can treat patients with chronic kidney disease

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Chronic kidney disease (CKD) is a major health issue worldwide. Many patients end up requiring regular dialysis to avoid kidney failure and stay alive. Despite the severity of the condition, there are currently no drugs available that improve kidney function.

1.318. Geriatric assessment in the emergency department reduces admission rates

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A comprehensive assessment of older adults being seen in the emergency department can help reduce hospital admissions, according to a study published online Aug. 21 in the Annals of Emergency Medicine.

1.319. Unlocking the immune system: Cellular 'toolkit' could reprogram cells for cancer therapy

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An international team led by researchers at Lund University in Sweden has identified the molecular tools needed to reprogram ordinary cells into specialized immune cells. The discovery, published in Immunity, could pave the way for more precise and personalized cancer immunotherapies.

1.320. 2010 to 2023 saw decline in births, increase in deaths in the United States

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From 2010 to 2023, the number of births in the United States declined, and the number of deaths increased, according to the Aug. 27 National Vital Statistics Reports, a publication from the National Center for Health Statistics.

1.321. How the distinctive folds in the brain cortex, seen in humans, whales, other animals, form

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One of the defining features of humans is our brain's remarkable capacity for language, planning, memory, creativity, and more. These abilities stem not just from our large brain size, but also from the folded structure of the brain's outer layer, the cerebral cortex.

1.322. Organoid-based platform enables precise evaluation of antibody and vaccine efficacy

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A research team has successfully developed the world's first nasal organoid-based SARS-CoV-2 neutralizing antibody evaluation platform.

1.323. With CDC in chaos, scientists and physicians piece together replacements for agency's lost work

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The CDC is in chaos and some groups are starting to step in and take over work the agency was doing.

1.324. Death toll from Legionnaires' disease outbreak in New York City rises to 7 and infections hit 114

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New York City health officials have discovered a seventh death linked to a Legionnaires' disease outbreak in Central Harlem, where more than 100 people have been diagnosed with the ailment.

1.325. Cholera outbreaks worsening, spreading to 31 countries: WHO

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The global cholera situation is worsening, with outbreaks across 31 countries and a surging fatality rate, the World Health Organization said Friday.

1.326. Metals and sulfate in air pollution mixture may contribute most to asthma hospitalizations

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Metals, particularly nickel and vanadium, and sulfate particles are the components of fine particulate air pollution (PM2.5) that most strongly contribute to the association between long-term exposure to air pollution and hospitalization among asthma sufferers, according to a new study led by Harvard T.H. Chan School of Public Health.

1.327. DNA variants that increase testosterone production in PCOS patients identified

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Increased testosterone levels are a consistent hormonal abnormality in women with polycystic ovary syndrome (PCOS). A study has identified specific DNA variants in the gene DENND1A, which increase testosterone production in PCOS. Using human PCOS cell models, researchers demonstrated that activating these DNA switches turns on DENND1A and drives testosterone production. This provides the first direct evidence that inherited DNA changes can cause the hormone imbalance at the core of PCOS.

1.328. Researchers determine how cells prevent RNA traffic jams under stress

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A University of Michigan study offers fresh insights into how cells manage molecular crises.

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