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mRNA directs body to produce nanobodies that unlock immune attack on colorectal cancer tumors

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  • 2025-10-14 23:20 event
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mRNA directs body to produce nanobodies that unlock immune attack on colorectal cancer tumors
A tiny molecule called a nanobody may succeed where today's cancer drugs often fail, according to University of Hawaiʻi at Mānoa researcher Stefan Moisyadi, who has been refining the concept for nearly a decade.

23. Research paves the way for potential anti-ulcer vaccine

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Since ancient times, it was thought that painful stomach ulcers were caused by eating spicy foods or having an unhealthy diet. But since then, researchers have found that Helicobacter pylori—a common bacterium found in over 60% of the world's population—was the real culprit behind most stomach ulcers and a high risk for stomach cancer.

24. Glycation-lowering compounds curb hunger, lower insulin resistance and extend lifespan in mice

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The same chemical reaction that makes a piece of freshly toasted bread delicious also happens in our bodies, with far less appetizing consequences. We're talking about the Maillard reaction, where sugars react with protein to form brown, sticky compounds in a process called glycation. Glycation is increasingly suspected to be a hidden driver of obesity, diabetes and accelerated aging. Researchers in the Kapahi lab have found a way to tame it in mice by feeding them a combination of glycation-lowering compounds.

25. Stress alters metabolic hormone with health consequences, study shows

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A long-studied metabolic hormone, FGF21, also acts as a stress hormone—a discovery that helps explain how psychological stress causes metabolic dysregulation and drives physical disease, according to a new study from researchers at Columbia University Mailman School of Public Health, Columbia University Irving Medical Center, and the Butler Columbia Aging Center. The findings are published in Nature Metabolism.

26. Eco-friendly silicon patch delivers clearer ultrasound images without harmful lead components

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Wearable ultrasound devices are actively used in various medical settings, including hospital diagnostics, rehabilitation monitoring, and telemedicine. However, most commercial devices currently rely on lead (Pb)-based piezoelectric ceramics, which are harmful to the human body and the environment, making it difficult to ensure both performance and safety.

27. Early menopause associated with increased risk of dementia

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A new international study led by University of Galway has found that entering menopause at an earlier age is associated with an increased risk of dementia.

28. Teens who start drinking as early as 12 have much higher risk of alcohol-related harms

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The earlier teenagers begin drinking before the minimum legal age for purchasing alcohol, the higher the risk of heavy drinking and alcohol-related harms in early adulthood.

29. Peppermints improve alertness when sick with a cold, study suggests

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Eating peppermints can increase alertness in people who are ill with the common cold, according to new research by Cardiff University scientists.

30. Common hospice medications linked to higher risk of death in people with dementia

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Hospice care aims to bring comfort, peace, and dignity to patients at the end of life. Yet for the growing number of Americans with dementia who enter hospice, their course is often long and unpredictable—making it especially important to ensure treatments align with each person's goals and stage of illness.

31. Does catching up on sleep actually work?

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Imagine it's Saturday morning, the perfect time to slow down, relax and... pay off debt? That's how many Americans start their weekend. No, we're not talking about the credit card bill. Many Americans are in debt—sleep debt.

32. mRNA directs body to produce nanobodies that unlock immune attack on colorectal cancer tumors

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A tiny molecule called a nanobody may succeed where today's cancer drugs often fail, according to University of Hawaiʻi at Mānoa researcher Stefan Moisyadi, who has been refining the concept for nearly a decade.

33. New gene therapy shows promise in preventing kidney disease in type 1 diabetes

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A new gene therapy approach aimed at protecting people with type 1 diabetes from developing diabetic kidney disease—a serious and common complication of the condition, has shown promising results in a University of Bristol study.

34. AI predicts future X-rays to help osteoarthritis patients and their doctors see what's coming

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An AI system that can predict what a patient's knee X-ray will look like a year in the future could transform how millions of people with osteoarthritis understand and manage their condition, according to research by the University of Surrey.

35. How lab-grown 'lungs' are helping fight infectious diseases

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What if scientists could build a realistic model of the human lung, not full-sized, but grown in the lab from living cells? Why would they do this? VIDO scientists based at the University of Saskatchewan have been exploring exactly that, and their work shows that these small, 3D structures referred to as "organoids" behave much like real lungs, giving scientists a powerful new way to study how viruses infect us.

36. Underweight children cost NHS as much per child as children with obesity, study finds

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The NHS incurs an estimated £340 million in additional health care costs annually due to weight-related health problems in children—but it is not just obesity driving the costs. New research from the University of Oxford reveals that underweight children need comparable medical support as those who are severely obese, challenging assumptions about childhood health priorities.

37. Experts present digital solution to close critical gap in medical guidelines implementation

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At the American Academy of Otolaryngology–Head and Neck Surgery Foundation (AAO-HNSF) 2025 Annual Meeting & OTO EXPO, leading experts presented findings today from a pioneering feasibility study exploring how clinical practice guidelines (CPGs) can be adapted for the digital age through computable formats.

38. Could this birth control shot increase your risk for brain tumor?

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One in four sexually active women has used injectable birth control, administered into the muscle by a clinician, but many may be unaware of its association with meningioma, the most common brain tumor in adults. In Europe and Canada, the drug is mandated to carry a warning—but not in the U.S.

39. Cancer's hidden sugar code: Glycan genes open diagnostic opportunities

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The complex sugar molecules that festoon our cells are often treated as little more than biological decoration. A new study suggests they hold hidden patterns—distinct signatures that can separate one cancer from another. The paper is published in the journal Cell Reports Methods.

40. Community water fluoridation works: Experts debunk myths, highlight lifelong benefits

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Experts from the University of Rochester's Eastman Institute for Oral Health underscore the safety, effectiveness, and enduring public health benefits of community water fluoridation in a commentary published in The Journal of the American Dental Association.

41. Psilocybin therapy linked to reduced depression symptoms in clinical trial

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Psilocybin could be the future of mental health care, with promising findings emerging from Australia's first research trial using psychedelics to treat depression, led by Swinburne University of Technology.

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