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Lymphoid-derived conventional dendritic cells (L-cDCs) may play a unique function associated with immune suppression and allergy induction, as reported by researchers from Japan. Long thought to arise only from myeloid lineages, cDCs were found to also originate from lymphoid progenitors. Using fluorescent reporter mice, the team tracked L-cDCs throughout the body, revealing their abundance in barrier tissues like skin and lungs and their distinct genetic signatures and functions.
A new exploratory analysis of the HIMALAYA phase III trial involving patients with unresectable hepatocellular carcinoma (uHCC, an advanced liver cancer that could not be treated with surgery or other localized treatments) has shown that one in five (19.6%) participants treated with STRIDE (Single Tremelimumab Regular Interval Durvalumab) a combination of two immunotherapies, remained alive after five years of follow-up versus one in 10 (9.4%) participants treated with sorafenib, a standard treatment for uHCC when the study was designed.
Researchers at Oregon Health & Science University have identified a gene that plays a crucial role in the brain's ability to form the protective layer around nerves known as myelin, potentially opening new doors to treatments for a rare childhood disorder and more common diseases such as multiple sclerosis.
Childhood gastrointestinal (GI) disorders may be predictive for interstitial cystitis (IC), according to a study published online June 25 in Neurourology & Urodynamics.
A pioneering international survey of people living with eating disorders has found that cannabis and psychedelics, such as "magic mushrooms" or LSD, were best rated as alleviating symptoms by respondents who self-medicated with the non-prescribed drugs.
Antibiotic resistance is one of the biggest health threats we face today. It's often blamed on the overuse of antibiotics, and for a good reason. But there's another major factor quietly driving this crisis that doesn't get as much attention: low vaccination rates.
New research from Karolinska Institutet demonstrates a link between inflammatory bowel disease and faster cognitive decline among dementia patients. The study, which is published in the journal Gut, indicates a need for personalized treatments, researchers say.
Researchers at Keele University have published the first investigation into the variation in the chemical makeup of calcifications caused by prostate cancer, in the hope of identifying new markers to improve early diagnosis.
The late, great comedian Barry Humphries (of Dame Edna fame) once spoke whimsically about the health benefits of kale. Just one fistful, he joked, contained enough essential vitamins, minerals and trace elements to keep you in a sedentary position in the bathroom for two whole days. Apparently, it wasn't tasty enough to justify a second helping.
Living near green spaces before and during pregnancy as well as in early childhood is associated with a reduced risk of neurodevelopmental disorders, according to Rutgers Health researchers.
Nearly half of drug-caused deaths by health care workers involved drugs that were obtained from their place of work, new research finds.
Aging skin stretches, contracts and buckles under pressure—and that's how wrinkles form, according to new experimental evidence from scientists at Binghamton University, State University of New York.
With an estimated 1.5 million new cases and 397,000 deaths worldwide, prostate cancer is the world's second most frequent cancer and the fifth leading cause of cancer death among men in 2022. Hormone therapy based on the inhibition of androgen receptor signaling (ARPi) is the mainstay of treatment for metastatic prostate cancer (mPC). However, cancer drug resistance ultimately arises, highlighting the need for more effective therapeutic strategies.
A team of researchers led by two University of Mississippi professors is working to unlock patterns and causes of the No. 1 killer of Mississippians: heart disease.
New research from Abertay University has shed fresh light on how neurodivergent (ND) people form and experience friendships, highlighting a strong preference for building connections with others who share their neurotype.
Eighteen-year-old Mark scrolls Instagram late at night, watching videos of fitness influencers showing off muscle gains and lifting the equivalent of a baby elephant off the gym floor.
When we think about the side effects of medicines, we might think of nausea, fatigue or dizziness. But there's another, lesser-known risk that can have lasting—and sometimes permanent—consequences: hearing loss. A wide range of prescription and over-the-counter drugs are known to be ototoxic, meaning they can damage the inner ear and affect hearing or balance.
Most of us want to enjoy later life feeling strong, connected, and mentally sharp. But how often do we stop to think about whether the things we're doing right now are helping us get there?
You pile your plate high at the buffet, savoring the freedom to try a little bit of everything. But while your tastebuds might be celebrating, your gut could be at risk.