Delinking pharmacy benefit manager compensation from drug list prices could unleash major savings

The Prognostic Nutritional Index (PNI) and systemic oxidative stress (SOS) score are independently associated with poorer prognosis of low-risk myelodysplastic syndrome (MDS), according to a study published online July 4 in the Journal of Clinical Medicine.

The U.S. Food and Drug Administration (FDA) has upgraded a recall of a commonly prescribed thyroid medication due to what it described as "subpotent" active ingredients.

For older patients with cancer and type 2 diabetes (T2D), glucagon-like peptide-1 receptor agonist (GLP-1 RA) use is associated with lower all-cause mortality than dipeptidyl peptidase-4 inhibitor (DPP4i) use, according to a study published online July 18 in JAMA Network Open.

Alopecia areata (AA) has a severe psychosocial impact, which is linked to illness perceptions and stigma more strongly than disease severity, according to a study published online July 16 in the British Journal of Dermatology.

Adherence to a combination of healthy lifestyle factors is associated with a lower risk for overactive bladder (OAB), according to a study published online June 30 in Frontiers in Nutrition.

Cardiovascular scientists at City St George's, University of London, have identified crucial clues from a heart rhythm test that could detect hidden heart disease in young people, according to research published in the European Journal of Preventive Cardiology.

A baby born at only 21 weeks of gestation last July in Iowa City, Iowa, has just celebrated his first birthday, and among his gifts is a Guinness world record for most premature baby.

During most eye infections or injuries, neutrophils, immune cells found in the blood, are usually the first line of defense. However, researchers at the Flaum Eye Institute and Del Monte Institute for Neuroscience at the University of Rochester have discovered that the retina responds differently than many other tissues in the body. When photoreceptor cells in the retina are damaged, microglia, or the brain's immune cells, respond, and the neutrophils are not recruited to help despite passing through nearby blood vessels.

Precision cancer treatment on a larger scale is moving closer now that researchers have developed an AI platform to tailor protein components and arm the patient's immune cells to fight cancer.

For the first time, researchers at the Netherlands Institute for Neuroscience and Amsterdam UMC have identified what happens in neural networks deep within the brain during obsessive thoughts and compulsive behaviors. Using electrodes implanted in the brain, they observed how specific brain waves became active. These brain waves serve as a biomarker for obsessive-compulsive disorder (OCD) and are an important step towards more targeted treatments.

Researchers at Uppsala University have identified a promising therapeutic approach for the challenging blood cancer multiple myeloma. In a new preclinical study, they demonstrate that a dual treatment with drugs that inhibit epigenetic regulation reduces tumor growth and induces cancer cell death. The findings are published in the journal Blood Advances.

Titanium dioxide (TiO2) has been classified as a possible human carcinogen through inhalation since 2006. This nanomaterial was used as a food coloring and opacifying agent (E171) until it was banned for use in food as a precautionary measure in France in 2020 and by the European Union in 2022. However, it is still widely used in many everyday products (toothpaste, sunscreen, make-up, medications, plastic, paper, paint, etc.).

While the incidence of breast cancer is highest for white women, Black women are more likely to have early-onset or more aggressive subtypes of breast cancer, such as triple-negative breast cancer. Among women under 50, the disparity is even greater: young Black women have double the mortality rate of young white women.

A wearable technology developed by Technion Professor Hossam Haick and colleagues in China enables real-time, noninvasive tracking and optimized treatment for diabetic patients.

Investigators led by Navdeep Chandel, Ph.D., the David W. Cugell, MD, Professor of Medicine in the Division of Pulmonary and Critical Care, have discovered how the metabolism of mitochondria supports T-cell proliferation and also prevents T-cell exhaustion in cancer and chronic infection, according to recent findings published in Nature Immunology.

A study comparing the effects of SARS-CoV-2 infection in lean and obese primates found different long-term consequences of the virus depending on prior obesity and metabolic disease.

Researchers have harnessed the power of artificial intelligence to design a blueprint for building a vaccine that aims to teach the body's immune system to fight cancer.

Melanoma testing could one day be done at home with a skin patch and test strip with two lines, similar to COVID-19 home tests, according to University of Michigan researchers.