How new information triggers the brain to navigate changing environments

New research has found that the endothelial cell-specific A disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) regulates abnormal blood vessel growth in the damaged retina, which can cause vision loss or impairment.

Researchers at VCU Massey Comprehensive Cancer Center and the VCU Institute of Molecular Medicine (VIMM) have discovered a new and potentially revolutionary way to treat glioblastoma (GBM), the most aggressive type of brain cancer, which currently has no curative treatment options.

Colorectal cancer (CRC) is the second most common cause of death from cancer in the US and the most prevalent malignant tumor worldwide. CRC refers to cancer in the colon or rectum, the two parts that make up the large intestine. In the US, deaths from CRC in people under 55 have been increasing since the mid-2000s, highlighting the need for effective treatments.

Burned-out primary care physicians are increasingly seeking safe haven in concierge care and other free-market models of practice. This has resulted in an exodus from traditional primary care practices and exacerbated an already acute shortage of primary care physicians. These alternative models also give patients more personalized care and attention. But for the rest of people who get their primary care from traditional practices, the already pressing shortage of primary care doctors often gets worse.

The Association for Molecular Pathology announced the publication of best practice recommendations for clinical laboratories developing and performing homologous recombination deficiency (HRD) testing. The manuscript, titled "Recommendations for Clinical Molecular Laboratories for Detection of Homologous Recombination Deficiency in Cancer: A Joint Consensus Recommendation of the Association of Molecular Pathology, Association of Cancer Care Centers and College of American Pathologists," was published in The Journal of Molecular Diagnostics.

Has your skin ever felt tight and dry after coming out of the ocean? You're not just imagining it. Scientists from Binghamton University, State University of New York have confirmed what beachgoers have felt for years—salt water dries out your skin—and why it happens.

Omega-3 fatty acids, popularly believed to reduce inflammation in the body, appear to increase certain inflammatory markers, researchers have found.

The newly launched South African Blood Regulatory (SABR) dataset reveals how genetic variation influences blood traits and gene activity in African populations, providing crucial insights into diseases like diabetes and heart disease.

UCLA scientists have uncovered a surprising survival strategy in cells, especially cancer cells, that may help explain how they adapt and keep growing even when nutrients are scarce and under metabolic stress. Their findings are published in Cancer & Metabolism.

Researchers at the University of Georgia's Center for Tropical and Emerging Global Diseases have developed the first test to determine whether treatment for Chagas disease was effective. The study is published in the journal eLife.

A comprehensive carcinogenicity study on the world's most used herbicide, glyphosate, involving scientists from Europe and the U.S., has found that low doses of the controversial weed killer cause multiple types of cancer in rats.

Education, body mass index (BMI), and hypertension play a role in the spread of tau tangles, a hallmark of Alzheimer's disease, according to longitudinal PET imaging data presented at the 2025 Society of Nuclear Medicine and Molecular Imaging Annual Meeting. For patients, timely modification of these risk factors could slow down disease progression. The abstract was published in the Journal of Nuclear Medicine.

The number of women using medicinal cannabis is growing in New Zealand and overseas. They use cannabis treatment for general conditions such as pain, anxiety, inflammation and nausea, as well as gynecological conditions, including endometriosis, pelvic floor conditions, and menopause.

A novel PET radiotracer can accurately detect a wide range of mold species that are linked to dangerous infections, according to new research presented at the Society of Nuclear Medicine and Molecular Imaging 2025 Annual Meeting and published in the Journal of Nuclear Medicine.

A novel molecular imaging agent targeting glypican-3 (GPC3) has demonstrated high sensitivity and specificity in detecting hepatocellular carcinoma (HCC), including tumors smaller than one centimeter, according to results from a pilot clinical study.

Researchers from Osaka Metropolitan University have identified a gene that, when activated by metabolic stress, damages pancreatic β-cells—the cells responsible for insulin production and blood sugar control—pushing them toward dysfunction. The findings highlight a promising new target for early intervention in type 2 diabetes. The study is published in the Journal of Biological Chemistry.

A pretreatment step could help transplanted pancreatic islets survive longer in patients with type 1 diabetes, according to a new preclinical study from Weill Cornell Medicine investigators. One combination of small molecules extended the cells' lives in female mice, and adding two molecules to the mixture boosted cell survival in male mice.

Researchers have pinpointed the precise pathway in the brain that suppresses pain in times of threatening situations.