Less than half of critical patients transfer to level I trauma centers

Certain brain cells are responsible for coordinating smooth, controlled movements of the body. But when those cells are constantly overactivated for weeks on end, they degenerate and ultimately die. This new observation made by scientists at Gladstone Institutes may help explain what goes awry in the brains of people with Parkinson's disease.

Inside every human brain lies a detailed map of the body, with different regions dedicated to different body parts—the hands, lips, feet and more. But what happens to this map when a body part is removed?

Researchers at Karolinska Institutet have discovered that mantle cell lymphoma (MCL), a rare and aggressive type of blood cancer, is already highly diverse at the time of diagnosis and continues to evolve in unique ways in each patient. The work is published in the journal Cell Reports Medicine.

A procedure which uses living heart valves may have expanded application as a treatment for various types of pediatric heart valve conditions.

Could a natural check on cancer be used to stop the disease? It's possible, but to leverage a system that nature designed, we must first understand it. Researchers led by a team at Purdue University are exploring a molecular mechanism that curbs the breakneck cell division associated with cancer. Their work opens the door to developing drugs that capitalize on the mechanism's effects.

A new biochemical approach to combat addiction, developed by researchers at the University of California San Diego and the National Institute on Drug Abuse (NIDA), has shown promising results in reducing drug-seeking behavior.

A study looking at the biophysical properties of an abnormal protein driving cancer cells is giving scientists new therapeutic clues for how to treat ependymoma, the third most common childhood brain tumor.

Eli Lilly says its new once-daily pill, orforglipron, helped people lose significant weight and lower blood sugar in a late-stage clinical trial.

This highlights an important preclinical model that could be successful in humans. The notoriously persistent, difficult-to-treat, lifelong and contagious virus—which insidiously attacks the liver—infects millions, particularly those with compromised immune systems and children. Globally, more than 296 million people are infected, with many living in South Africa.

"If you can't handle this, you'll never keep up with your peers."

Only a few decades ago, a diagnosis of lupus could mean giving up the dream of having children. Women with systemic autoimmune diseases like lupus were warned that pregnancy was too risky—both for them and their unborn babies. Fast forward to today, and the story is remarkably different.

Texas passed a landmark law in June 2025, supported by former Gov. Rick Perry, that allocates US$50 million to support research on ibogaine, one of the most powerful psychedelics, for treating opioid addiction and treatment-resistant PTSD.

In a new study, artificial intelligence matched and potentially exceeded the performance of gastroenterologists and conventional scoring in evaluating endoscopies of Crohn's disease patients.

Researchers at the University of California San Diego School of Medicine have identified a new investigational drug that shows promise in treating metabolic dysfunction-associated steatohepatitis (MASH), a serious form of fatty liver disease linked to obesity and type 2 diabetes that can lead to cirrhosis, liver failure, and even liver cancer.

In my youth, I spent an unreasonable amount of time questioning why A-level chemistry was a prerequisite for medical school. Why was it as essential as biology? Why did I need to learn about electrons and entropy? The penny finally dropped when my rather brilliant teachers turned my attention towards the periodic table.

A novel, multi-analyte test developed by researchers at the Johns Hopkins Kimmel Cancer Center, its Ludwig Center and the Johns Hopkins Department of Neurosurgery can accurately identify brain cancers using small samples of cerebrospinal fluid (CSF), offering a promising new tool to guide clinical decision-making.

A UCLA study has mapped a critical brain hub in mice that regulates stress responses and social behavior, shedding new light on the neural roots of psychiatric conditions such as post-traumatic stress disorder, depression and anxiety.

Investigators at Mass General Brigham and the Richard A. and Susan F. Smith Center for Outcomes Research at Beth Israel Deaconess Medical Center have uncovered how patients' health care spending has changed following the implementation of the No Surprises Act in 2022, a bipartisan law prohibiting unexpected or "surprise" bills after patients receive out-of-network medical care.