Racing against antibiotic resistance: Scientists fear funding cuts will slow momentum

A multi-institutional clinical trial conducted at the UNC Lineberger Comprehensive Cancer Center and 21 other U.S. sites found that a single administration of autologous tumor-infiltrating lymphocyte (TIL) cell therapy helped stabilize metastatic head and neck squamous cell carcinoma (HNSCC) in some patients. This finding is significant, as many of these patients had previously undergone multiple treatments without success.

Metabolic health before and during pregnancy may have a bigger influence on risks for mother and baby than simply controlling weight gain. Data from a recent paper by Pennington Biomedical researchers indicates that pregnant women with metabolically unhealthy obesity were more likely to develop gestational diabetes than those who were metabolically healthy.

Spironolactone does not reduce a composite outcome of cardiovascular mortality and hospitalization due to heart failure among patients receiving maintenance dialysis, according to a study published online Aug. 16 in The Lancet and presented at the 62nd European Renal Association Congress, held from June 4 to 7 in Vienna.

For over three decades, the zebrafish has advanced preclinical biomedical research: hundreds of individuals can be studied simultaneously, and even whole-brain activity can be recorded in living animals. Its limitation, however, lies in its social nature: as a schooling species, its behavior is always influenced by the presence—or absence—of conspecifics. This means that when studied in isolation, results may be skewed by its innate social tendencies.

Over the past 50 years, rates of obesity and type-2 diabetes have soared, while sperm quality has plummeted. Driving these changes could be the increasing popularity of ultra-processed foods, which have been linked to a range of poor health outcomes. However, scientists still aren't sure whether it's the industrial nature of the ingredients themselves, the processing of the foods, or whether it's because they lead people to eat more than they should.

Asthma, depression, anxiety, and hypothyroidism are associated with heart failure with preserved ejection fraction (HFpEF) and heart failure with reduced ejection fraction (HFrEF) among women, according to a study published online Aug. 22 in the Journal of Primary Care and Community Health.

When genetic testing reveals a rare DNA mutation, doctors and patients are frequently left in the dark about what it actually means. Now, researchers at the Icahn School of Medicine at Mount Sinai have developed a powerful new way to determine whether a patient with a mutation is likely to actually develop disease, a concept known in genetics as penetrance.

U.S. cancer survivors are significantly more likely to take medications for depression and anxiety compared with noncancer survivors, according to a study published online Aug. 19 in JAMA Network Open.

Children with acute lymphoblastic leukemia (ALL) from the lowest socioeconomic status (SES) neighborhoods have an increased risk for mortality, according to a study published online Aug. 22 in Blood Advances.

New research from cardiovascular scientists at UC Davis Health reveals that stress affects more than just the mind—it also alters heart function at the molecular level.

Long-term cocoa extract supplementation does not reduce the risk for incident hypertension but does reduce hypertension incidence among those with normal systolic blood pressure (BP) at baseline, according to a study published online Aug. 20 in Hypertension.

The sexually transmitted disease gonorrhea has increased in the past 10 years. No one knows exactly why gonorrhea is spreading—but experts suspect a mix of better testing and changing sexual habits. At the same time, we face reduced treatment options due to antimicrobial resistance.

A research team led by the Department of Medicine and the Department of Orthopedics and Traumatology, under the School of Clinical Medicine, LKS Faculty of Medicine of the University of Hong Kong (HKUMed), has uncovered a serious risk of joint infection following knee surgery, linked to allergy mislabeling.

An artificial intelligence (AI)-enabled bundled system of sensors and coaching facilitates significant improvements in glycemic outcomes and de-escalation of glucose-lowering pharmacotherapy, according to a study published online Aug. 20 in NEJM Catalyst.

A new research letter published Aug. 25 in JAMA Pediatrics estimates the extent to which obesity-related conditions (ORCs) are tied to obesity and overweight in adolescents and young adults in the United States. In this paper, lead author and medical student, Ashwin Chetty used publicly available data from the National Health and Nutrition Examination Survey (NHANES) to quantify how much obesity can cause obesity-related conditions and what the impact of preventing or treating obesity could be.

A world-first clinical trial has found that a simple daily nasal spray can significantly reduce the risk of COVID-19 in cancer patients, offering a potential new tool to protect vulnerable people from the virus.

Cleveland Clinic Cole Eye Institute researchers have identified a potential association between the use of GLP-1 receptor agonist (GLP-1RA) therapy and a reduced risk of non-infectious uveitis, a type of eye inflammation.

Moderate exercise in older age shapes brain activity which can reduce the number of "tip of the tongue" moments, as new research shows that higher cardiorespiratory fitness alters our brain's ability to reach for the right word at the right time.