Simple therapies outperform high-tech options for knee arthritis pain and mobility

Acute pancreatitis is among the most common gastrointestinal conditions requiring inpatient hospital care in the United States.

On Tuesday, the U.S. Food and Drug Administration announced a new initiative to offer expedited reviews for new medicines, an initiative that will apply to drugs that administration officials determine promote "the health interests of Americans."

In the largest study of its kind, researchers from The University of Texas MD Anderson Cancer Center identified three subgroups of patients with large B-cell lymphoma (LBCL) who have different levels of benefit from CD19 chimeric antigen receptor (CAR) T cell therapy.

Researchers at the Johns Hopkins Kimmel Cancer Center and Department of Radiation Oncology and Molecular Radiation Sciences uncovered a new tumor-suppressive response that could lead to novel therapies targeting hard-to-treat cancers.

A study published by researchers at University Hospitals Connor Whole Health and Case Western Reserve University School of Medicine has revealed that Whole Systems Traditional Chinese Medicine (WS-TCM), when integrated with in vitro fertilization (IVF), significantly improves patient-reported levels of stress, pain, and anxiety within a single treatment session. The researchers are also among the first to describe the real-world integration of WS-TCM treatments such as acupuncture within a fertility clinic at a U.S. academic medical center.

In a study of newborn piglets, infection with influenza A was associated with disruptions in the piglets' nasal and gut microbiomes, and with potentially detrimental changes in gene activity in the hippocampus, a brain structure that plays a central role in learning and memory. Maternal vaccination against the virus during pregnancy appeared to offer some protection from those changes in the piglets.

A new international study coordinated by the European Alzheimer's and Dementia Biobank (EADB) consortium sheds light on how genetic risk factors for Alzheimer's disease (AD) vary—and remain consistent—across global populations. The study represents the first worldwide examination of polygenic risk scores (PRS) and their relationship to the likelihood of developing Alzheimer's disease.

A new review, published in Microbiology, is the first to systematically review the potential effects of psychotropics (the drugs used to treat bipolar disorder) on the gut microbiome of treated and untreated bipolar individuals.

A new paper from Columbia University Mailman School of Public Health, Butler Columbia Aging Center, and Columbia Irving Medical Center introduces a scientific framework for understanding the biological foundation of health—what the researchers term "Intrinsic Health." Published in Science Advances, the study lays the groundwork for measuring and promoting health itself, rather than merely treating disease.

Hope isn't just wishful thinking—it's a powerful emotional force that gives our lives meaning. Now, a new groundbreaking study from the University of Missouri shows it may be even more essential to well-being than happiness or gratitude.

The gut microbiome, a vast assortment of bacteria and other microorganisms that inhabit our digestive system, plays a critical role in converting food into energy. Many of these microbes follow rhythmic cycles of activity throughout the day. However, high-fat diets and other factors can disrupt these rhythms and contribute to metabolic disease.

Until 2023, Adriana Alatorre was in peak condition, running at least 30 miles a week before a mild bout of COVID knocked her off her feet. The 49-year-old Pittsburgh running store manager seemed to recuperate quickly, but after hitting the pavement again she increasingly felt exhausted. When plummeting blood pressure sapped so much energy that she couldn't do laundry and grocery-shop the same day, she suspected long COVID, but finding solid information was a wild goose chase: Online chat boards offered "hocus pocus," she said, while doctors offered no treatments.

When you think about ticks, you might picture nightmarish little parasites, stalking you on weekend hikes or afternoons in the park.

Every night, millions of people stop breathing without knowing it. Not once, but sometimes hundreds of times. Their remedy? A mask, a hum and the steady whisper of pressurized air.

Scientists from the National University of Singapore (NUS) have developed NAPTUNE (Nucleic Acids and Protein biomarkers Testing via Ultra-sensitive Nucleases Escalation), a point-of-care assay that identifies trace amounts of disease-related genetic material, including nucleic acid and protein markers, in less than 45 minutes. Importantly, it accomplished this without the need for laboratory equipment or complex procedures.

Children born to obese mothers are at higher risk of developing metabolic disorders, even if they follow a healthy diet themselves. A new study from the University of Bonn offers an explanation for this phenomenon. In obese mice, certain cells in the embryo's liver are reprogrammed during pregnancy. This leads to long-term changes in the offspring's metabolism. The researchers believe that these findings could also be relevant for humans. The study has now been published in the journal Nature.

A team of physicians from Bochum are the first to successfully use CAR T-cell therapy to treat two patients with a rare autoimmune disease of the peripheral nervous system. This treatment modifies endogenous immune cells such that they can specifically target and eliminate B lymphocytes, which are here the origin of autoimmunity. This is the world's first clinical report on the use of CAR T-cell therapy to treat a serious autoimmune neuropathy.

New research found that youth who become increasingly addicted to social media, mobile phones or video games are at greater risk of suicidal thoughts, suicide attempts and emotional or behavioral issues. The study, published June 18 in JAMA, was led by researchers at Weill Cornell Medicine, Columbia University and University of California, Berkeley.