Study links obesity-driven fatty acids to breast cancer, warns against high-fat diets like keto

For patients with knee osteoarthritis, aerobic activities such as walking, cycling, or swimming are likely to be the best exercise for improving pain, function, gait performance, and quality of life, finds a study published in The BMJ.

Impostor participants threaten the integrity of health research, and by extension, the policies and clinical decisions built on it, warn experts in The BMJ today.

Sodium-glucose cotransporter-2 (SGLT-2) inhibitors used to treat type 2 diabetes are associated with an 11% lower risk of autoimmune rheumatic diseases, such as rheumatoid arthritis and lupus, compared with another group of diabetes drugs called sulfonylureas, finds a study from South Korea published in The BMJ.

Boston Children's Hospital, along with Broad Clinical Labs and Roche Sequencing Solutions, has demonstrated that rapid genomic sequencing and interpretation are achievable in a matter of hours. This milestone not only sets a Guinness World Records for the fastest human whole genome sequencing to date but represents a significant clinical development that would expedite more precise treatments for critically ill babies in the NICU.

An experimental gene therapy developed by researchers at UCLA, University College London and Great Ormond Street Hospital has restored and maintained immune system function in 59 of 62 children born with ADA-SCID, a rare and deadly genetic immune disorder.

Sepsis remains one of the leading causes of mortality in hospitalized patients worldwide, and innovative therapeutic strategies are urgently needed.

Providing practical help to a close friend—such as picking up medication, cooking a meal or helping with household chores—may be linked to a more positive mood among older adults in daily life.

In haunted houses across the country this month, threatening figures will jump out of the shadows, prompting visitors—wide-eyed and heart racing—to instinctively freeze and flee.

A low-fat vegan diet that doesn't limit calories or carbohydrates could help people with type 1 diabetes reduce insulin use and insulin costs, according to new research by the Physicians Committee for Responsible Medicine published in BMC Nutrition.

Will it be possible to treat severe kidney inflammation with fewer drugs in the future? A new study by the University Hospital Bonn (UKB), the University of Bonn, and the University of Hamburg gives cause for hope. The researchers show that even low, repeated doses of steroids could be enough to stop inflammation in particularly aggressive crescentic glomerulonephritis (cGN).

The influenza A virus (IAV) has been the cause of six major flu pandemics, responsible for 50 to 100 million deaths globally. In the U.S. alone, it is estimated that despite seasonally updated vaccines, IAV infections still lead to 140,000 to 710,000 hospitalizations and 12,000 to 52,000 deaths annually.

Mayo Clinic researchers have identified a molecular "switch" in lung cells that helps them decide when to repair tissue and when to fight infection. This discovery could guide future regenerative therapies for chronic lung diseases.

Two new research papers from the Living Brain Project at Mount Sinai present what is, by several metrics, the largest investigation ever performed of the biology of the living human brain. The papers present unequivocal evidence that brain tissue from living people has a distinct molecular character, an observation that until now was missed because brain tissue from living people is rarely studied.

Researchers at the University of California, Irvine have developed a 3D human colon model integrated with bioelectronics to aid in colorectal cancer research and drug discovery. The "3D in vivo mimicking human colon" enables precision, personalized medicine and offers a more ethical, accurate and cost-effective alternative to traditional animal testing.

New research from the University of Delaware finds that LGBTQ+ adolescents in Delaware face strikingly higher rates of mental health challenges and substance use compared to their peers.

Activating specific neurons in a part of the brain that serves as the body's master circadian pacemaker caused mice to eat significantly more during a time of day when they would normally be at rest, a UT Southwestern Medical Center study shows. The findings, published in Cell Reports, could lead to new strategies to help people lose weight, including night shift workers who have a higher prevalence of obesity.

A new perspective article jointly published in the Journal of Dental Research and JADA Foundational Science highlights the transformative potential of generative artificial intelligence (AI) in dental, oral, and craniofacial research while cautioning against its misuse and ethical pitfalls.

The drug sulthiame reduces the number of breathing pauses and improves sleep quality in patients with obstructive sleep apnea, according to a European clinical study in which the University of Gothenburg played a significant role. The findings offer hope for a drug-based treatment for people who cannot tolerate breathing masks.