Bioelectronic-integrated artificial colon eliminates need for animal testing

Sepsis remains one of the leading causes of mortality in hospitalized patients worldwide, and innovative therapeutic strategies are urgently needed.

Providing practical help to a close friend—such as picking up medication, cooking a meal or helping with household chores—may be linked to a more positive mood among older adults in daily life.

In haunted houses across the country this month, threatening figures will jump out of the shadows, prompting visitors—wide-eyed and heart racing—to instinctively freeze and flee.

A low-fat vegan diet that doesn't limit calories or carbohydrates could help people with type 1 diabetes reduce insulin use and insulin costs, according to new research by the Physicians Committee for Responsible Medicine published in BMC Nutrition.

A team from Huntsman Cancer Institute at the University of Utah (the U) has found that triple-negative breast cancer is fueled by lipids and that these fatty acids are a key feature of obesity that promote tumor growth. Their research, conducted in preclinical mouse models, suggests that breast cancer patients and survivors with obesity could benefit from lipid-lowering therapies—and that they should avoid high-fat weight loss regimens like ketogenic diets.

Will it be possible to treat severe kidney inflammation with fewer drugs in the future? A new study by the University Hospital Bonn (UKB), the University of Bonn, and the University of Hamburg gives cause for hope. The researchers show that even low, repeated doses of steroids could be enough to stop inflammation in particularly aggressive crescentic glomerulonephritis (cGN).

The influenza A virus (IAV) has been the cause of six major flu pandemics, responsible for 50 to 100 million deaths globally. In the U.S. alone, it is estimated that despite seasonally updated vaccines, IAV infections still lead to 140,000 to 710,000 hospitalizations and 12,000 to 52,000 deaths annually.

Mayo Clinic researchers have identified a molecular "switch" in lung cells that helps them decide when to repair tissue and when to fight infection. This discovery could guide future regenerative therapies for chronic lung diseases.

Two new research papers from the Living Brain Project at Mount Sinai present what is, by several metrics, the largest investigation ever performed of the biology of the living human brain. The papers present unequivocal evidence that brain tissue from living people has a distinct molecular character, an observation that until now was missed because brain tissue from living people is rarely studied.

New research from the University of Delaware finds that LGBTQ+ adolescents in Delaware face strikingly higher rates of mental health challenges and substance use compared to their peers.

Activating specific neurons in a part of the brain that serves as the body's master circadian pacemaker caused mice to eat significantly more during a time of day when they would normally be at rest, a UT Southwestern Medical Center study shows. The findings, published in Cell Reports, could lead to new strategies to help people lose weight, including night shift workers who have a higher prevalence of obesity.

A new perspective article jointly published in the Journal of Dental Research and JADA Foundational Science highlights the transformative potential of generative artificial intelligence (AI) in dental, oral, and craniofacial research while cautioning against its misuse and ethical pitfalls.

The drug sulthiame reduces the number of breathing pauses and improves sleep quality in patients with obstructive sleep apnea, according to a European clinical study in which the University of Gothenburg played a significant role. The findings offer hope for a drug-based treatment for people who cannot tolerate breathing masks.

If we can understand exactly how neurodegenerative diseases such as ALS progress in fruit flies, we may also gain valuable insights into how these diseases develop in humans. Research by neurobiologist Marije Been of Radboud University shows that the formation of certain protein clumps may mark the onset of ALS. She will defend her Ph.D. thesis on this topic on 21 October.

A new study published in Scientific Reports indicates that amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) have an extremely high geographic association, even after controlling for race, gender, wealth, latitude, and access to neurological health care.

Researchers from A*STAR Institute of Molecular and Cell Biology (A*STAR IMCB) have identified markers of two critical stem cell populations that drive colorectal cancer formation.

Endovascular aneurysm repair is a minimally invasive technique for the treatment of abdominal aortic aneurysms—life-threatening bulges in the aorta's abdominal section. However, it carries the risk of recurrence owing to endoleaks after stent graft implantation, necessitating regular follow-up, especially since these leaks cannot be easily linked to specific symptoms.

Immune checkpoint inhibitors are well known as a form of cancer treatment. Researchers at UZH have now identified a new, important function of these inhibitors: promotion of tissue healing. This finding could help advance the treatment of fibrosis and chronic wounds.