Synaptic changes in the brains of patients with frontotemporal dementia can be modeled in the laboratory

Research led by the University of Michigan's Kresge Hearing Research Institute and the University of Rochester illuminates the mechanisms through which humans can pick out and focus on single sounds in noisy environments.

A nationwide, longitudinal study characterized how physician attrition rates from clinical practice have changed and the factors associated with a differential likelihood of attrition. The study found that the rate of physicians' attrition from clinical practice has increased from 2013 to 2019.

In a quest to develop new antiviral drugs for COVID-19 and other diseases, a collaboration led by scientists at The Wertheim UF Scripps Institute has identified a potential new drug against the virus that causes COVID-19.

Results of a recently published long-term follow-up of the ASAP trial, which was conducted at universities and clinics across Germany, show that the genetic risk of disease, not remission status, determines overall survival of patients with high-risk acute myeloid leukemia (AML) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Furthermore, there is no benefit of remission induction with standard salvage chemotherapy prior to allo-HSCT.

Invasive lung squamous cell carcinoma (LUSC) accounts for approximately one-quarter of all lung cancers, but therapeutic options for LUSC remain limited, primarily due to the absence of well-defined, targetable molecular alterations. Therefore, histopathologic features are increasingly being explored as tools to enhance prognostic accuracy and guide treatment decisions.

The inhalers people depend on to breathe are also warming the planet, producing annual emissions equivalent to more than half a million cars in the United States alone, researchers said Monday in a major new study.

The Centers for Disease Control and Prevention adopted recommendations by a new group of vaccine advisers, and stopped recommending COVID-19 shots for anyone—leaving the choice up to patients.

Despite progress in past decades to reduce the burden of cardiovascular disease (CVD), it remains the leading cause of death in the U.S. and worldwide. Data within the past 10 years indicate deceleration and reversal of declines in CVD morbidity and mortality. These trends may be further worsened by the prevalence of low heart health, particularly among young adults.

Generalized anxiety disorder affects 1 in 20 U.S. adults. Those with serious symptoms may isolate themselves to the point where they rarely leave their home and are unable to work and build meaningful relationships. Standard medications may make little difference.

The U.S. Food and Drug Administration (FDA) is reviewing whether to change the warning label on hormone replacement therapy (HRT) drugs used to treat menopause symptoms, a move many experts say is long overdue.

A new method of taking microscopic images of a live mouse's retina through the eye allows researchers to record the reaction of brain cells to disease and treatment. The Kobe University development is more easily applicable than previous methods and promises to advance research on and treatment of vision-related diseases.

Nearly 1 in 5 residents (17.8%) of Agder, Norway, reported being discriminated against in the past year. "Discrimination tends to fly under the radar in public discourse. We assume we have legislation and measures in place that work, but this study suggests otherwise," says Jan Georg Friesinger from the University of Agder.

In an advance for critical care medicine, two international studies published in parallel in the journal Nature Medicine have established a new unified framework for understanding the biological chaos of sepsis and other life-threatening illnesses. A University of Malta researcher, Dr. Brendon Scicluna of the Department of Applied Biomedical Science, Faculty of Health Sciences, designed and spearheaded one of the studies and made significant contributions to the second, placing the University at the forefront of the global effort to bring precision medicine to the sickest patients in our hospitals.

Pancreatic neuroendocrine neoplasms (PNENs) are a rare form of cancer that affects hormone-producing cells in the pancreas. Although uncommon, their incidence has been rising steadily over the past few decades.

Dr. Brian Ciruna had no intention of studying scoliosis, a condition that causes unnatural curvature of the spine. However, the unexpected discovery about a decade ago that zebrafish also develop curved spines left him wondering what was causing the spine to bend and whether there was some connection to the human form of the disease. It turns out that this small, minnow-like fish has a lot to tell researchers about a condition that affects 3% to 4% of children and young teens in Canada.

Researchers at the UNC School of Medicine and the University of Vermont have developed a more precise way to assess stroke risk in people with atrial fibrillation (A-Fib), a condition that affects 10.5 million Americans and is a leading cause of stroke.

For decades, researchers have worked to unravel the mysteries of post-traumatic epilepsy (PTE), a form of epilepsy that emerges after a traumatic brain injury (TBI). Now, a new study led by Texas A&M University neuroscientist Dr. Samba Reddy offers a sweeping view of how far the science has come and how far it needs to go.

Tobacco smoking is associated with an increased risk of hypertension (high blood pressure), a new UM study has found, and testing patients' urine can help to verify their smoking status and assess this risk.