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Researchers at the University of California, Irvine have developed a 3D human colon model integrated with bioelectronics to aid in colorectal cancer research and drug discovery. The "3D in vivo mimicking human colon" enables precision, personalized medicine and offers a more ethical, accurate and cost-effective alternative to traditional animal testing.
New research from the University of Delaware finds that LGBTQ+ adolescents in Delaware face strikingly higher rates of mental health challenges and substance use compared to their peers.
Activating specific neurons in a part of the brain that serves as the body's master circadian pacemaker caused mice to eat significantly more during a time of day when they would normally be at rest, a UT Southwestern Medical Center study shows. The findings, published in Cell Reports, could lead to new strategies to help people lose weight, including night shift workers who have a higher prevalence of obesity.
A new perspective article jointly published in the Journal of Dental Research and JADA Foundational Science highlights the transformative potential of generative artificial intelligence (AI) in dental, oral, and craniofacial research while cautioning against its misuse and ethical pitfalls.
The drug sulthiame reduces the number of breathing pauses and improves sleep quality in patients with obstructive sleep apnea, according to a European clinical study in which the University of Gothenburg played a significant role. The findings offer hope for a drug-based treatment for people who cannot tolerate breathing masks.
If we can understand exactly how neurodegenerative diseases such as ALS progress in fruit flies, we may also gain valuable insights into how these diseases develop in humans. Research by neurobiologist Marije Been of Radboud University shows that the formation of certain protein clumps may mark the onset of ALS. She will defend her Ph.D. thesis on this topic on 21 October.
A new study published in Scientific Reports indicates that amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) have an extremely high geographic association, even after controlling for race, gender, wealth, latitude, and access to neurological health care.
Researchers from A*STAR Institute of Molecular and Cell Biology (A*STAR IMCB) have identified markers of two critical stem cell populations that drive colorectal cancer formation.
Endovascular aneurysm repair is a minimally invasive technique for the treatment of abdominal aortic aneurysms—life-threatening bulges in the aorta's abdominal section. However, it carries the risk of recurrence owing to endoleaks after stent graft implantation, necessitating regular follow-up, especially since these leaks cannot be easily linked to specific symptoms.
Immune checkpoint inhibitors are well known as a form of cancer treatment. Researchers at UZH have now identified a new, important function of these inhibitors: promotion of tissue healing. This finding could help advance the treatment of fibrosis and chronic wounds.
Researchers at the Central Institute of Mental Health (CIMH) in Mannheim, together with international partners, have developed patient-derived brain organoids for the first time in order to better understand the rare genetic disease LIS1-lissencephaly. The study shows how genetic changes disrupt cell structure and protein function and thus cause different disease severities. Initial laboratory results suggest that drugs that are already available could help.
Use lifestyle interventions to show no signs of type 2 diabetes for at least three months? There's a code for that: E11.A.
New research by UCLA Health has identified a sex-chromosome linked gene that drives inflammation in the female brain, offering insight into why women are disproportionately affected by conditions such as Alzheimer's disease and multiple sclerosis as well as offering a potential target for intervention.
Food insecurity affects about one in 13 (7.8%) U.K. households, with higher rates of food insecurity found in Black British households and people with long-term mental health conditions, according to a study published in the open-access journal PLOS One by Maddy Power of the London School of Hygiene and Tropical Medicine, U.K., and colleagues.
Most children with neurogenic bladder (NGB) and diagnosed with febrile urinary tract infection (UTI) in the emergency department (ED) did not meet a commonly recommended definition for UTI, according to a study published online Sept. 15 in the Journal of Pediatric Urology.
Child atopic dermatitis (AD) is associated with higher maternal depression scores, according to a study published online Oct. 5 in the Journal of the American Academy of Dermatology.
For better or worse, screentime has become a mainstay in family life—but FIU researchers say boundaries are possible with just a few simple changes.
Poisonings and deaths linked to use of local anesthetics decreased over the last decade, but poisonings from lidocaine increased, according to two studies published online recently in Regional Anesthesia & Pain Medicine and the British Journal of Anaesthesia.
Sometimes, you discover history in a garage, stored in dusty boxes, or in memories that go unspoken for decades. Often, it falls to the next generation—curious and respectful—to do the necessary work of sifting, sorting and asking questions.