How a popular sweetener could be damaging your brain's defenses

Exposure to a class of synthetic chemicals known as per- and polyfluoroalkyl substances (PFAS)—often called "forever chemicals"—may increase the risk of developing type 2 diabetes, according to a new study led by Mount Sinai researchers. The findings were published in eBioMedicine.

For patients with idiopathic intracranial hypertension (IIH), glucagon-like peptide 1 receptor agonist (GLP-1 RA) treatment is associated with improved clinical outcomes compared with conventional therapies, according to a study published online July 14 in JAMA Neurology.

For adults with neurogenic lower urinary tract dysfunction (NLUTD) or interstitial cystitis/bladder pain syndrome (IC/BPS), robot-assisted laparoscopic supratrigonal cystectomy with augmentation cystoplasty (RA-SC-AC) is feasible, according to a study published in the July issue of BJUI Compass.

A prospective cohort study examined the associations of different physical activity patterns with all-cause, cardiovascular (CV) and cancer mortality among adults with diabetes.

Matthew Leming, Ph.D., and Hyungsoon Im, Ph.D. of the Center for Systems Biology at Massachusetts General Hospital, are the co-corresponding authors of a paper published in Alzheimer's & Dementia, "Differential dementia detection from multimodal brain images in a real-world dataset."

Close to 5 million above-ground swimming pools have been recalled following the drowning deaths of nine children over two decades.

A team led by José Antonio Gil Gómez (Universitat Politècnica de València) and Inmaculada Montoya Castilla (Universitat de València) has developed emoWELL, a video game that helps improve emotional management in young people between the ages of 18 and 25.

In a study published in Alzheimer's & Dementia, a team led by Dr. Sha Feng from the Shenzhen Institute of Advanced Technology of the Chinese Academy of Sciences—collaborating with Dr. Jed A. Barash from the Massachusetts Veterans Home at Chelsea and Prof. W. Andrew Kofke from the University of Pennsylvania—has found that regular opioid use is associated with an increased risk of dementia, particularly vascular dementia.

Many people with cancer experience dramatic loss of muscle and fat tissue. In many cases, even the heart muscle is affected, which further weakens the body. This wasting syndrome, known as cachexia, affects around half of all cancer patients. It is a major cause of therapy resistance, complications, and increased mortality.

A new study by researchers at Columbia University Mailman School of Public Health has identified that uranium's isotopic composition can be used as a biomarker to noninvasively measure accumulation of uranium in the kidneys. Uranium from drinking water can accumulate in the kidneys—even at low levels of exposure—and this newly identified biomarker may serve as an early warning sign of kidney damage.

A new study led by researchers at Mount Sinai Health System has identified distinct biological signatures in patients with mild Crohn's disease, offering a potential pathway toward more personalized and less aggressive treatment strategies.

Research in the International Journal of Data Mining and Bioinformatics discusses a new approach to demand forecasting for the pharmaceutical retail sector based on an artificial intelligence model. The findings hold promise for improving accuracy in one of the industry's most persistent logistical challenges: managing sales that swing sharply during promotional periods. The new system works better than traditional models by distinguishing between routine demand and the short-term surges driven by marketing campaigns.

In a recent landmark study, scientists have unveiled how HIV-1 penetrates the cell's nuclear barrier—a discovery that could reshape antiviral strategies. The research, led by Professor Peijun Zhang, eBIC director at Diamond, used cutting-edge cryo-electron microscopy to capture HIV-1 viral cores in the process of nuclear import—an elusive but critical step in the virus's life cycle.

It is a common belief that mental illness runs in families. While it is true that heredity plays a role, in reality, the vast majority of cases—such as schizophrenia, bipolar disorder, depression, and borderline personality disorder—occur in people without any known hereditary predisposition.

Children who carry a particularly high number of genetic variants associated with ADHD also have a statistically greater risk of experiencing severe neglect and childhood maltreatment.

When thinking about future events, optimists' brains work similarly, while pessimists' brains show a much larger degree of individuality. The Kobe University finding offers an explanation why optimists are seen as more sociable—they may share a common vision of the future.

New research from The University of Texas at Arlington reveals that social media platforms can play a potentially life-saving role for young people navigating difficult circumstances at home.

Cannabis use disorder (CUD) is associated with increased risk of benign salivary gland tumors, according to a research letter published online July 17 in JAMA Otolaryngology-Head & Neck Surgery.